NOAEL Studies
Emollient
Dicaprylyl Carbonate NOAEL Studies
INCI: DICAPRYLYL CARBONATE
CAS: 1680-31-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC120 | range172.498 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; mMUSST | sheet=Data_invitro; excel_row=7774; Record_ID=skin_sensitization_invitro_1872; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9075115; Assay=mMUSST; Endpoint=CD86, EC120; Response_Modifier=range; Reported_Response=602.18 to 2410.81; Reported_Response_Unit=uM; Conversion_Factor_Value=286.456; Conversion_Factor_Source=EPA Dashboard; Converted_Response=172.498 to 690.591; Converted_Response_Unit=ug/mL; Response=172.498 - 690.591; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9075115 |
| NTP_ICE_skin_sensitization | Depletion Cys | 4.8 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=254; Record_ID=skin_sensitization_invitro_73; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9075115; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=4.8; Reported_Response_Unit=%; Response=4.8; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9075115 |
| NTP_ICE_skin_sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=229; Record_ID=skin_sensitization_invitro_73; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9075115; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9075115 |
ToxValDB_ECHA_IUCLID 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c534a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15695/7/6/2?documentUUID=b654044e-ae75-42f8-b17e-05992c197679; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15839489:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34d81de019e61081a098cdc7468666e4 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =293 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630627:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9dd4e1a14b6b23ef189335aadfbbefd5 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 609A3V1SUA | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H34O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"609A3V1SUA"} |
| openFDA substances | FDA UNII substance identifier | 609A3V1SUA | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H34O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"609A3V1SUA"} |
| openFDA substances | FDA UNII substance identifier | 609A3V1SUA | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H34O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"609A3V1SUA"} |
| openFDA substances | FDA UNII substance identifier | 609A3V1SUA | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C17H34O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"609A3V1SUA"} |