NOAEL Studies
Cosmetic Ingredient
Didecyldimonium Chloride NOAEL Studies
INCI: DIDECYLDIMONIUM CHLORIDE
CAS: 7173-51-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_dermal 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2544; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2538; Record_ID=acute_dermal_443; Data_Type=In Vivo; Formulation_ID=MIX437; Formulation_Name=Secure Fungicide; Percent_Active_Ingredient=18.0; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2539; Record_ID=acute_dermal_126; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_dermal | LD50 | >5050 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2541; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5050.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_acute_inhalation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | EPA Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5260; Record_ID=acute_inhalation_222; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX321; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_inhalation | GHS Classification | 5 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5267; Record_ID=acute_inhalation_54; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=5; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_inhalation | LC50 | >2.16 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5262; Record_ID=acute_inhalation_481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.16; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_inhalation | LC50 | >5.06 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5264; Record_ID=acute_inhalation_54; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.06; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_inhalation | LC50 | >2.02 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5265; Record_ID=acute_inhalation_222; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX321; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.02; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_acute_inhalation | LC50 | range0.052 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5266; Record_ID=acute_inhalation_351; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX437; Formulation_Name=Secure Fungicide; Percent_Active_Ingredient=18.0; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0.052 and <0.51; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_acute_oral 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12964; row=15932; data_type=In Vivo; mixture=Mixture; formulation_id=MIX657; formulation_name=Secure; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=18.0; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12747; row=15933; data_type=In Vivo; mixture=Mixture; formulation_id=MIX321; formulation_name=MGK 29461; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.003; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=15934; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.4; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15935; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.76; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13230; row=15940; data_type=In Vivo; mixture=Mixture; formulation_id=MIX300; formulation_name=Lonza Formulation R-82; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=3.906; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12964; row=15927; data_type=In Vivo; mixture=Mixture; formulation_id=MIX657; formulation_name=Secure; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=18.0; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12747; row=15928; data_type=In Vivo; mixture=Mixture; formulation_id=MIX321; formulation_name=MGK 29461; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.003; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13230; row=15929; data_type=In Vivo; mixture=Mixture; formulation_id=MIX300; formulation_name=Lonza Formulation R-82; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=3.906; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=15930; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.4; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15931; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.76; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =331 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9645; row=15926; data_type=In Vivo; mixture=Chemical; chemical_name=Didecyldimethylammonium chloride; preferred_name=Didecyldimethylammonium chloride; dtxsid=DTXSID9032537; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1750 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12964; row=15936; data_type=In Vivo; mixture=Mixture; formulation_id=MIX657; formulation_name=Secure; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=18.0; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12747; row=15937; data_type=In Vivo; mixture=Mixture; formulation_id=MIX321; formulation_name=MGK 29461; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.003; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=15938; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.4; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15939; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Didecyl dimethyl ammonium chloride; preferred_name=Didecyldimethylammonium chloride; percent_active_ingredient=0.76; dtxsid=DTXSID9032537; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =84 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9672; row=15941; data_type=In Vivo; mixture=Chemical; chemical_name=Didecyldimethylammonium chloride; preferred_name=Didecyldimethylammonium chloride; dtxsid=DTXSID9032537; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =329 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_9643; row=15942; data_type=In Vivo; mixture=Chemical; chemical_name=Didecyldimethylammonium chloride; preferred_name=Didecyldimethylammonium chloride; dtxsid=DTXSID9032537; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =238 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9641; row=15943; data_type=In Vivo; mixture=Chemical; chemical_name=Didecyldimethylammonium chloride; preferred_name=Didecyldimethylammonium chloride; dtxsid=DTXSID9032537; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 18.65 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3692; Record_ID=adme_parameters_365; Data_Type=Measured; DTXSID=DTXSID9032537; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=18.65; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3693; Record_ID=adme_parameters_365; Data_Type=Measured; DTXSID=DTXSID9032537; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_dart 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 3 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134896; Record_ID=dart_2931; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0034642;CUI;Rales; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134897; Record_ID=dart_3316; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 3 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134898; Record_ID=dart_2922; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134899; Record_ID=dart_3320; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134900; Record_ID=dart_3318; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134901; Record_ID=dart_3323; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1806781;CUI;Short; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134902; Record_ID=dart_3313; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 20 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=134903; Record_ID=dart_3311; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 10 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134904; Record_ID=dart_3178; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0034642;CUI;Rales; Reference=ToxRefDB v2 , ID = 6025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 10 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134905; Record_ID=dart_3023; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 10 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Offspring survival early | sheet=Data; excel_row=134906; Record_ID=dart_3021; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, Offspring survival early; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0015954;CUI;Fetal Viability|UMLS;C4086636;CUI;Number of Dead Fetuses; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 3 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134907; Record_ID=dart_2940; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0391853;CUI;Physical activity decreased; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_dart | LOEL | 3 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=134908; Record_ID=dart_2926; Data_Type=In Vivo; DTXSID=DTXSID9032537; Assay=DART, In life observation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0034642;CUI;Rales; Reference=ToxRefDB v2 , ID = 6023; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_endocrine 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 8.77563586952748 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7874; RecordID=ARPathway2016_259; DatasetName=ARPathway2016; DTXSID=DTXSID9032537; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=8.77563586952748; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | AC50 | 19.0571698882926 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7880; RecordID=ERPathway2016_42; DatasetName=ERPathway2016; DTXSID=DTXSID9032537; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=19.0571698882926; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | ACC | 8.30535999448496 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7875; RecordID=ARPathway2016_259; DatasetName=ARPathway2016; DTXSID=DTXSID9032537; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=8.30535999448496; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | ACC | 12.2235650081618 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7881; RecordID=ERPathway2016_42; DatasetName=ERPathway2016; DTXSID=DTXSID9032537; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=12.2235650081618; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | Model Score | 0.403 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7876; RecordID=ARPathway2016_259; DatasetName=ARPathway2016; DTXSID=DTXSID9032537; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.403; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | Model Score | 0.0182 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7877; RecordID=ARPathway2016_259; DatasetName=ARPathway2016; DTXSID=DTXSID9032537; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0182; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | Model Score | 0.00313 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7882; RecordID=ERPathway2016_42; DatasetName=ERPathway2016; DTXSID=DTXSID9032537; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00313; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_endocrine | Model Score | 0.085 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7883; RecordID=ERPathway2016_42; DatasetName=ERPathway2016; DTXSID=DTXSID9032537; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.085; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_eye_irritation 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2886; Record_ID=eye_irritation_411; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID205; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2887; Record_ID=eye_irritation_724; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID608; Formulation_Name=Lonza Formulation R-82; Percent_Active_Ingredient=3.906; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2891; Record_ID=eye_irritation_795; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID655; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2886; Record_ID=eye_irritation_411; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID205; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2887; Record_ID=eye_irritation_724; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID608; Formulation_Name=Lonza Formulation R-82; Percent_Active_Ingredient=3.906; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2891; Record_ID=eye_irritation_795; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID655; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2886; Record_ID=eye_irritation_411; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID205; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2887; Record_ID=eye_irritation_724; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID608; Formulation_Name=Lonza Formulation R-82; Percent_Active_Ingredient=3.906; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2891; Record_ID=eye_irritation_795; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID655; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2886; Record_ID=eye_irritation_411; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID205; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2887; Record_ID=eye_irritation_724; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID608; Formulation_Name=Lonza Formulation R-82; Percent_Active_Ingredient=3.906; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2891; Record_ID=eye_irritation_795; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID655; Formulation_Name=MGK 29461; Percent_Active_Ingredient=0.003; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_skin_irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1951; Record_ID=skin_irritation_invivo_300; Data_Type=In Vivo; Formulation_ID=MIX437; Formulation_Name=Secure Fungicide; Percent_Active_Ingredient=18; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1952; Record_ID=skin_irritation_invivo_423; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1954; Record_ID=skin_irritation_invivo_667; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1955; Record_ID=skin_irritation_invivo_713; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=0.76; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1959; Record_ID=skin_irritation_invivo_1047; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1961; Record_ID=skin_irritation_invivo_1126; Data_Type=In Vivo; Formulation_ID=MIX437; Formulation_Name=Secure Fungicide; Percent_Active_Ingredient=18; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
NTP_ICE_skin_sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13633; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13633; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13633; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13633; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.4; Mixture=Mixture; DTXSID=DTXSID9032537; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9032537 |
ToxRefDB_ToxRefDB_v3_pod.csv 30 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =124.9 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption; dose_level=3; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =104.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight; dose_level=3; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =119.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F1_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =101 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F1_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=3; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =225.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 90 day | SUB | study_id=6020; toxval_study_source_id=studyid6020_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-protein-protein|clinical chemistry-glucose-glucose|pathology gross-intestine large-distended|clinical chemistry-phosphorus-phosphorus|in life observation-body weight-body weight gain|in life observation-clinical signs-perineal soiling|organ weight-kidney-absolute|in life observation-clinical signs-emaciation|organ weight-liver-absolute|in life observation-clinical signs-defecation (diarrhea)|pathology microscopic-lymph node-hyperplasia|pathology gross-intestine large-[other]|pathology gross-stomach-hemorrhage|clinical chemistry-globulins-globulins|in life observation-clinical signs-general pallor|in life observation-body weight-body weight|pathology gross-intestine large-dilatation|in life observation-food consumption-food consumption|pathology gross-spleen-reduced size|pathology microscopic-lymph node-hematopoietic cell proliferation erythrocytic|pathology microscopic-spleen-atrophy|pathology microscopic-intestine large-inflammation|clinical chemistry-albumin-albumin|pathology gross-lymph node-discolored|pathology microscopic-liver-depletion glycogen|in life observation-mortality-mortality; dose_level=5; study_year=1988; study_citation=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =175.4 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 90 day | SUB | study_id=6020; toxval_study_source_id=studyid6020_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-emaciation|pathology microscopic-liver-depletion glycogen|pathology microscopic-intestine large-inflammation|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-glucose-glucose|clinical chemistry-protein-protein|in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|pathology gross-stomach-hemorrhage|in life observation-mortality-mortality|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-clinical signs-defecation (diarrhea)|pathology gross-intestine large-distended|in life observation-body weight-body weight|pathology gross-spleen-reduced size|organ weight-kidney-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-clinical signs-general pallor|pathology gross-intestine large-dilatation|in life observation-body weight-body weight gain|organ weight-liver-absolute|clinical chemistry-globulins-globulins|clinical chemistry-phosphorus-phosphorus|pathology microscopic-spleen-atrophy|in life observation-clinical signs-perineal soiling|pathology gross-lymph node-discolored|pathology gross-intestine large-[other]; dose_level=5; study_year=1988; study_citation=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 day to 90 day | SUB | study_id=6022; toxval_study_source_id=studyid6022_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology gross-skin-ulcer|pathology microscopic-skin-inflammation|pathology microscopic-skin-hyperkeratosis|in life observation-clinical signs-scabbing|pathology microscopic-skin-degeneration|pathology gross-skin-scabbing|pathology microscopic-skin-ulcer|in life observation-clinical signs-erythema|pathology microscopic-skin-edema; dose_level=1; study_year=1988; study_citation=Gill, MW and van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; dsstox_substance_id=DTXSID9032537; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =10 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=6023; toxval_study_source_id=studyid6023_Adult Pregnancy_Fetal_MF_reproductive; toxval_effect_list=offspring survival early-dead fetuses-dead fetuses; dose_level=3; study_year=1989; study_citation=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=6023; toxval_study_source_id=studyid6023_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-oral discharge|in life observation-clinical signs-defecation (diarrhea)|in life observation-clinical signs-abnormal respiratory sounds|in life observation-body weight-body weight gain|in life observation-clinical signs-altered breathing rate|in life observation-clinical signs-reduced activity|in life observation-mortality-mortality|pathology gross-stomach-lesion(s) (nos)|in life observation-clinical signs-discharge on cageboard|pathology gross-urinary bladder-distended|in life observation-clinical signs-[other]|pathology gross-lung-irregular surface|pathology gross-esophagus-lesion(s) (nos)|in life observation-body weight-body weight|pathology gross-liver-irregular surface|pathology gross-stomach-hemorrhage|in life observation-clinical signs-labored respiration|pathology gross-stomach-distended; dose_level=1; study_year=1989; study_citation=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =20 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=6025; toxval_study_source_id=studyid6025_Fetal_Fetal_MF_developmental; toxval_effect_list=developmental malformation-bone-incomplete ossification|developmental malformation-bone-short|developmental malformation-bone-[other]; dose_level=3; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats. Bushy Run Research Center, Study no. 53-534. MRID 41886701.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =193.1 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 week to 78 week | CHR | study_id=6027; toxval_study_source_id=studyid6027_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=1991; study_citation=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =155.5 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 week to 78 week | CHR | study_id=6027; toxval_study_source_id=studyid6027_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=3; study_year=1991; study_citation=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =83 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 week to 104 week | CHR | study_id=6028; toxval_study_source_id=studyid6028_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hyperplasia|pathology microscopic-lymph node-hemosiderosis|in life observation-body weight-body weight|pathology microscopic-lymph node-hemorrhage|pathology microscopic-lymph node-histiocytosis|in life observation-body weight-body weight gain|pathology microscopic-liver-infiltration cellular; dose_level=3; study_year=1991; study_citation=Gill, MW, JS Chun, and CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =64 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 week to 104 week | CHR | study_id=6028; toxval_study_source_id=studyid6028_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-lymph node-histiocytosis|pathology microscopic-lymph node-hemorrhage|pathology microscopic-lymph node-hemosiderosis; dose_level=3; study_year=1991; study_citation=Gill, MW, JS Chun, and CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 day to 90 day | SUB | study_id=6022; toxval_study_source_id=studyid6022_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-skin-inflammation; dose_level=2; study_year=1988; study_citation=Gill, MW and van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; dsstox_substance_id=DTXSID9032537; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =12 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 day to 90 day | SUB | study_id=6022; toxval_study_source_id=studyid6022_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-hyperkeratosis; dose_level=3; study_year=1988; study_citation=Gill, MW and van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; dsstox_substance_id=DTXSID9032537; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =20 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 month to 12 month | CHR | study_id=6026; toxval_study_source_id=studyid6026_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-cholesterol-cholesterol|in life observation-clinical signs-mucoid stools|in life observation-clinical signs-soft stools|in life observation-clinical signs-emesis; dose_level=3; study_year=1991; study_citation=Schulze, GE. 1991. Chronic oral toxicity study of didecyldimethylammoniumchloride in dogs. Hazleton Washington, Inc., Study no. 2545-102. MRID 41970401.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =62.6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight; dose_level=2; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =52.6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =58.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight; dose_level=2; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =48.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=3838; toxval_study_source_id=studyid3838_Adult_F1_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =74.3 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 90 day | SUB | study_id=6020; toxval_study_source_id=studyid6020_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-phosphorus-phosphorus|in life observation-clinical signs-perineal soiling|in life observation-body weight-body weight gain|in life observation-clinical signs-emaciation|organ weight-kidney-absolute|organ weight-liver-absolute|pathology gross-intestine large-distended|clinical chemistry-glucose-glucose|clinical chemistry-protein-protein|pathology gross-intestine large-[other]|clinical chemistry-globulins-globulins|pathology gross-stomach-hemorrhage|pathology microscopic-lymph node-hyperplasia|in life observation-clinical signs-defecation (diarrhea)|pathology gross-intestine large-dilatation|in life observation-body weight-body weight|in life observation-clinical signs-general pallor|pathology microscopic-liver-depletion glycogen|pathology gross-lymph node-discolored|in life observation-mortality-mortality|pathology microscopic-intestine large-inflammation|clinical chemistry-albumin-albumin|pathology microscopic-spleen-atrophy|in life observation-food consumption-food consumption|pathology microscopic-lymph node-hematopoietic cell proliferation erythrocytic|pathology gross-spleen-reduced size; dose_level=4; study_year=1988; study_citation=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =60.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 90 day | SUB | study_id=6020; toxval_study_source_id=studyid6020_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|pathology gross-stomach-hemorrhage|in life observation-mortality-mortality|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-clinical signs-emaciation|pathology microscopic-liver-depletion glycogen|pathology microscopic-intestine large-inflammation|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-glucose-glucose|clinical chemistry-protein-protein|clinical chemistry-globulins-globulins|clinical chemistry-phosphorus-phosphorus|pathology microscopic-spleen-atrophy|in life observation-clinical signs-perineal soiling|pathology gross-lymph node-discolored|pathology gross-intestine large-[other]|in life observation-clinical signs-defecation (diarrhea)|pathology gross-intestine large-distended|in life observation-body weight-body weight|pathology gross-spleen-reduced size|organ weight-kidney-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-clinical signs-general pallor|pathology gross-intestine large-dilatation|in life observation-body weight-body weight gain|organ weight-liver-absolute; dose_level=4; study_year=1988; study_citation=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 day to 90 day | SUB | study_id=6022; toxval_study_source_id=studyid6022_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-ulcer|pathology microscopic-skin-inflammation|pathology gross-skin-scabbing|in life observation-clinical signs-scabbing|pathology microscopic-skin-degeneration|pathology microscopic-skin-acanthosis|pathology microscopic-skin-edema|pathology gross-skin-ulcer|pathology microscopic-skin-hyperkeratosis|in life observation-clinical signs-erythema; dose_level=0; study_year=1988; study_citation=Gill, MW and van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; dsstox_substance_id=DTXSID9032537; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =3 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=6023; toxval_study_source_id=studyid6023_Adult Pregnancy_Fetal_MF_reproductive; toxval_effect_list=offspring survival early-dead fetuses-dead fetuses; dose_level=2; study_year=1989; study_citation=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=6025; toxval_study_source_id=studyid6025_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food efficiency|in life observation-body weight-body weight gain|in life observation-clinical signs-defecation (diarrhea)|in life observation-clinical signs-abnormal respiratory sounds|in life observation-clinical signs-oral discharge|in life observation-food consumption-food consumption|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth; dose_level=1; study_year=1991; study_citation=Neeper-Bradley, TL. 1991. Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats. Bushy Run Research Center, Study no. 53-534. MRID 41886701.; dsstox_substance_id=DTXSID9032537; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =93.1 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 week to 78 week | CHR | study_id=6027; toxval_study_source_id=studyid6027_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=2; study_year=1991; study_citation=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =76.3 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 week to 78 week | CHR | study_id=6027; toxval_study_source_id=studyid6027_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=2; study_year=1991; study_citation=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =41 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 week to 104 week | CHR | study_id=6028; toxval_study_source_id=studyid6028_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hyperplasia|in life observation-body weight-body weight|pathology microscopic-lymph node-hemosiderosis|pathology microscopic-liver-infiltration cellular|pathology microscopic-lymph node-hemorrhage|pathology microscopic-lymph node-histiocytosis|in life observation-body weight-body weight gain; dose_level=2; study_year=1991; study_citation=Gill, MW, JS Chun, and CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =32 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 week to 104 week | CHR | study_id=6028; toxval_study_source_id=studyid6028_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-lymph node-hemosiderosis|pathology microscopic-lymph node-hemorrhage|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-lymph node-histiocytosis; dose_level=2; study_year=1991; study_citation=Gill, MW, JS Chun, and CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; dsstox_substance_id=DTXSID9032537; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =234 | mg/kg bw/day | Rat | oral | chronic; 93 days | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb300; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837396_15849779:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d3ffefdaee2ac86b3c0f2c09cb1430e8 |
| ToxValDB_ECHA_IUCLID | LOAEL | =445 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2fc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849777:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ada4125000f752a196b4168b1fc53a59 |
| ToxValDB_ECHA_IUCLID | LOAEL | =750 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2fc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849778:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be11c06cbc2e6e0d7468d4fb535a817f |
| ToxValDB_ECHA_IUCLID | LOAEL | =115 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb308; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849780:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a3ba809ffe0023f9c08dd3003cc7d72 |
| ToxValDB_ECHA_IUCLID | LOAEL | =225 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb308; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849781:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea53641f03ded628a47411acabf02a4f |
| ToxValDB_ECHA_IUCLID | NOAEL | >=20 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be15b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21102/7/9/3?documentUUID=de0509ef-3d1d-4b74-b9a0-b6702bc63000; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824946:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f13550ef0181b894f52741df574f91e |
| ToxValDB_ECHA_IUCLID | NOAEL | ~74.3 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea4e4b0a7c65d1ca466; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/24926?documentUUID=da13b08c-2c85-42ee-93e7-df3017c07b66; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849712_15849713:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_24f25a26afa6db515fbb267bb4df6c32 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~60.7 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea4e4b0a7c65d1ca466; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/24926?documentUUID=da13b08c-2c85-42ee-93e7-df3017c07b66; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849714_15849715:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ade03365d7ccf3730643eefaf86f4e7 |
| ToxValDB_ECHA_IUCLID | NOAEL | =165 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849775:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a0938642c5ac98754ef881bcc5a155c8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =220 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb2f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849776:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49ce294eedad7054ed344f9a304f5694 |
| ToxValDB_ECHA_IUCLID | NOAEL | =117 | mg/kg bw/day | Rat | oral | chronic; 93 days | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb300; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837396_15849779:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e80735045fc3a4859345bb8e086b567b |
| ToxValDB_ECHA_IUCLID | NOAEL | =130 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb314; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849783:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_91dee9c9cf9a004fb2ef25b48fbdc820 |
| ToxValDB_ECHA_IUCLID | NOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb314; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849784:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b5f4032204419a472c7b6d33cd1975cd |
| ToxValDB_ECHA_IUCLID | NOAEL | ~15 | mg/kg bw/day | Dog | oral | - | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5ce4b0a7c65d2216e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/17471?documentUUID=ce0de577-01d7-4d2e-b434-d6db06d0fdae; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|food efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|other; STUDY_GROUP=ECHA IUCLID:15850628:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f4181ff1a02b914b1d82f3830981be3 |
| ToxValDB_ECHA_IUCLID | NOAEL | =260 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab47e4b0a7c65d1b99c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/9/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855917_15862975:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87af0a076b7583326fc58a3d621c5690 |
| ToxValDB_ECHA_IUCLID | NOAEL | =425 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab47e4b0a7c65d1b99c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/9/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855917_15862975:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1bf6871b7eb23217ba0f3ac469618b64 |
| ToxValDB_ECHA_IUCLID | NOEL | =10 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed6e4b0a7c65d1cb310; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25860/7/6/2?documentUUID=f58f004e-d5f2-4aef-9430-4839dfaf3b1f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15849782:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ed55de830ce10fe572ebc14477271d0b |
ToxValDB_EPA_OPP 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_OPP | PAD (RfD) | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15789244_15789246:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba64ced46f5a485400b729e811bc3efe |
ToxValDB_ToxRefDB 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =124.9 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704797_15704798_15704799_15704800:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69fba5f7867c1eec7335b82339a29a56 |
| ToxValDB_ToxRefDB | LEL | =104.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704801_15704802_15704803_15704804:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4ef4491fdb36eefc28fc72f46607403 |
| ToxValDB_ToxRefDB | LEL | =119.8 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704805_15704806_15704807_15704808:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_637a2cbacb7e1ef05b3597ac31f705ca |
| ToxValDB_ToxRefDB | LEL | =101 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704809_15704810_15704811_15704812:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fa6770b152816c0042d2596fcb141cd |
| ToxValDB_ToxRefDB | LEL | =225.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; TITLE=90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats; AUTHOR=van Miller, JP; EXTERNAL_SOURCE_ID=6020; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-protein-protein|systemic: in life observation-food consumption-food consumption|systemic: pathology gross-spleen-reduced size|systemic: pathology microscopic-lymph node-hematopoietic cell proliferation erythrocytic|systemic: clinical chemistry-glucose-glucose|systemic: in life observation-clinical signs-general pallor|systemic: pathology microscopic-spleen-atrophy|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: pathology microscopic-intestine large-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology gross-intestine large-distended|systemic: pathology microscopic-lymph node-hyperplasia|systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-phosphorus-phosphorus|systemic: pathology gross-intestine large-[other]|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-lymph node-discolored|systemic: pathology gross-stomach-hemorrhage|systemic: in life observation-clinical signs-perineal soiling|systemic: clinical chemistry-globulins-globulins|systemic: pathology microscopic-liver-depletion glycogen|systemic: organ weight-kidney-absolute|systemic: pathology gross-intestine large-dilatation|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-mortality-mortality|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15710563_15710564_15710565_15710566:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd2870de15f7a0a085fdaec26ae86a50 |
| ToxValDB_ToxRefDB | LEL | =175.4 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=van Miller, JP. 1988. 90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-506. MRID 40966302.; TITLE=90-day subchronic oral toxicity study with didecyldimethylammoniumchloride in rats; AUTHOR=van Miller, JP; EXTERNAL_SOURCE_ID=6020; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-globulins-globulins|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: pathology gross-intestine large-distended|systemic: pathology microscopic-liver-depletion glycogen|systemic: pathology microscopic-intestine large-inflammation|systemic: in life observation-food consumption-food consumption|systemic: clinical chemistry-albumin-albumin|systemic: pathology gross-stomach-hemorrhage|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-phosphorus-phosphorus|systemic: in life observation-mortality-mortality|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology gross-spleen-reduced size|systemic: organ weight-kidney-absolute|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: clinical chemistry-glucose-glucose|systemic: pathology microscopic-spleen-atrophy|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-perineal soiling|systemic: in life observation-clinical signs-general pallor|systemic: pathology gross-intestine large-dilatation|systemic: pathology gross-lymph node-discolored|systemic: clinical chemistry-protein-protein|systemic: pathology gross-intestine large-[other]|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15710567_15710568_15710569_15710570:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0487e69c3b2ee2ef6a7a405573b76f1b |
| ToxValDB_ToxRefDB | LEL | =2 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; TITLE=90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats; AUTHOR=Gill, MW & van Miller, JP; EXTERNAL_SOURCE_ID=6022; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: pathology gross-skin-ulcer|systemic: pathology microscopic-skin-hyperkeratosis|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-clinical signs-erythema|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-skin-degeneration|systemic: pathology gross-skin-scabbing|systemic: pathology microscopic-skin-edema; STUDY_GROUP=ToxRefDB_dup_-_15710571_15710572_15710573:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_916dab8af17c28b74f78dc16d1b50190 |
| ToxValDB_ToxRefDB | LEL | =10 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; TITLE=Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbit; AUTHOR=Tyl, RW; EXTERNAL_SOURCE_ID=6023; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-dead fetuses-dead fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710578_15710579_15710580_15710581:M/F:fetusadult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33b4c35dd37892014f78b4b6746fbe46 |
| ToxValDB_ToxRefDB | LEL | =1 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; TITLE=Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbit; AUTHOR=Tyl, RW; EXTERNAL_SOURCE_ID=6023; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-oral discharge|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-altered breathing rate|systemic: pathology gross-esophagus-lesion(s) (nos)|systemic: in life observation-mortality-mortality|systemic: pathology gross-stomach-lesion(s) (nos)|systemic: pathology gross-urinary bladder-distended|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-[other]|systemic: pathology gross-lung-irregular surface|systemic: pathology gross-stomach-hemorrhage|systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-clinical signs-discharge on cageboard|systemic: pathology gross-liver-irregular surface|systemic: pathology gross-stomach-distended; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710582_15710583_15710584:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7768448f428efc8807bbc9e745f88b52 |
| ToxValDB_ToxRefDB | LEL | =193.1 | mg/kg bw/day | Mouse | oral | chronic; 78 weeks | chronic | LONG_REF=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; TITLE=Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice; AUTHOR=MW Gill, SJ Hermansky, CL Wagner; EXTERNAL_SOURCE_ID=6027; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710605_15710606_15710607_15710608:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c9d405103c5b2eb2ab2bf3e8992ca007 |
| ToxValDB_ToxRefDB | LEL | =155.5 | mg/kg bw/day | Mouse | oral | chronic; 78 weeks | chronic | LONG_REF=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; TITLE=Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice; AUTHOR=MW Gill, SJ Hermansky, CL Wagner; EXTERNAL_SOURCE_ID=6027; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710609_15710610_15710611_15710612:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13dbc73d6d90ebd8c7cb5d33048bedce |
| ToxValDB_ToxRefDB | LEL | =83 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gill, MW, JS Chun, & CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; TITLE=Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats; AUTHOR=Gill, MW, JS Chun, & CL Wagner; EXTERNAL_SOURCE_ID=6028; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-lymph node-hemorrhage|systemic: pathology microscopic-lymph node-hemosiderosis|systemic: pathology microscopic-lymph node-histiocytosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-liver-infiltration cellular|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710613_15710614_15710615_15710616:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee1af90d6c85fa461c303f138b199603 |
| ToxValDB_ToxRefDB | LEL | =64 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gill, MW, JS Chun, & CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; TITLE=Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats; AUTHOR=Gill, MW, JS Chun, & CL Wagner; EXTERNAL_SOURCE_ID=6028; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-lymph node-hemorrhage|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-lymph node-hemosiderosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-lymph node-histiocytosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710617_15710618_15710619_15710620:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20a5c317141740c31a6b369a3527e8e8 |
| ToxValDB_ToxRefDB | LOAEL | =6 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; TITLE=90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats; AUTHOR=Gill, MW & van Miller, JP; EXTERNAL_SOURCE_ID=6022; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-inflammation; STUDY_GROUP=ToxRefDB_dup_-_15710571_15710572_15710573:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27fabe5e831dae54bb70d8894ea03450 |
| ToxValDB_ToxRefDB | LOAEL | =12 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & van Miller, JP. 1988. 90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 51-554. MRID 41305901.; TITLE=90-day subchronic dermal toxicity study with didecyldimethylammoniumchloride in rats; AUTHOR=Gill, MW & van Miller, JP; EXTERNAL_SOURCE_ID=6022; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperkeratosis; STUDY_GROUP=ToxRefDB_dup_-_15710574_15710575_15710576_15710577:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25411b36c3c956cdb3f27903bb7abddc |
| ToxValDB_ToxRefDB | LOAEL | =3 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; TITLE=Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbit; AUTHOR=Tyl, RW; EXTERNAL_SOURCE_ID=6023; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-clinical signs-reduced activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15710582_15710583_15710584:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8dccb74b54d61ac13b6488d3a301290e |
| ToxValDB_ToxRefDB | LOAEL | =20 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | LONG_REF=Schulze, GE. 1991. Chronic oral toxicity study of didecyldimethylammoniumchloride in dogs. Hazleton Washington, Inc., Study no. 2545-102. MRID 41970401.; TITLE=Chronic oral toxicity study of didecyldimethylammoniumchloride in dogs; AUTHOR=Schulze, GE; EXTERNAL_SOURCE_ID=6026; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-emesis|systemic: in life observation-clinical signs-soft stools|systemic: clinical chemistry-cholesterol-cholesterol|systemic: in life observation-clinical signs-mucoid stools; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15710597_15710598_15710599_15710600:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d61bbfff6eba784b0964aa0fe087e3c3 |
| ToxValDB_ToxRefDB | NEL | =62.6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704797_15704798_15704799_15704800:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e22942a79db5ebbcabc1bc2bd37ca184 |
| ToxValDB_ToxRefDB | NEL | =52.6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704801_15704802_15704803_15704804:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00cdc32db7abff9ed3329592b91c582c |
| ToxValDB_ToxRefDB | NEL | =58.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704805_15704806_15704807_15704808:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a40015f63f37b7ade1f484d29693e74e |
| ToxValDB_ToxRefDB | NEL | =48.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet. Bushy Run Research Center, Study No. 52-648. MRID 41804501.; TITLE=Two-Generation Reproduction Study in Sprague-Dawley (CD) Rats with Didecyl dimethyl ammonium chloride Administered in the Diet; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=3838; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704809_15704810_15704811_15704812:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1804f9ef4dce4688686eb0d628bb47e |
| ToxValDB_ToxRefDB | NEL | =3 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Tyl, RW. 1989. Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbits. Bushy Run Research Center, Study no. 51-590. MRID 41018701.; TITLE=Developmental toxicity study of didecyldimethylammoniumchloride administered by gavage to New Zealand White rabbit; AUTHOR=Tyl, RW; EXTERNAL_SOURCE_ID=6023; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-dead fetuses-dead fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710578_15710579_15710580_15710581:M/F:fetusadult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29b4c77d3313c56413b4b7a4a2d3dde7 |
| ToxValDB_ToxRefDB | NEL | =1 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Neeper-Bradley, TL. 1991. Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats. Bushy Run Research Center, Study no. 53-534. MRID 41886701.; TITLE=Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=6025; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: in life observation-food consumption-food efficiency|systemic: in life observation-clinical signs-oral discharge|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710589_15710590_15710591_15710592:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_16ce8a7c2f635ffe29051dfe16a269c6 |
| ToxValDB_ToxRefDB | NEL | =10 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Neeper-Bradley, TL. 1991. Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats. Bushy Run Research Center, Study no. 53-534. MRID 41886701.; TITLE=Developmental toxicity evaluation of Didecyldimethylammoniumchloride administered by gavage to CD (Sprague-Dawley) rats; AUTHOR=Neeper-Bradley, TL; EXTERNAL_SOURCE_ID=6025; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-bone-[other]|developmental: developmental malformation-bone-incomplete ossification|developmental: developmental malformation-bone-short; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15710593_15710594_15710595_15710596:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd21483fe3a5abe225c7402d938558b7 |
| ToxValDB_ToxRefDB | NEL | =93.1 | mg/kg bw/day | Mouse | oral | chronic; 78 weeks | chronic | LONG_REF=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; TITLE=Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice; AUTHOR=MW Gill, SJ Hermansky, CL Wagner; EXTERNAL_SOURCE_ID=6027; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710605_15710606_15710607_15710608:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c721e3508351933e18fda9ea67afb57b |
| ToxValDB_ToxRefDB | NEL | =76.3 | mg/kg bw/day | Mouse | oral | chronic; 78 weeks | chronic | LONG_REF=MW Gill, SJ Hermansky, CL Wagner. 1991. Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice. Bushy Run Research Center, Study no. 53-528. MRID 41802301.; TITLE=Chronic dietary oncogenicity study with didecyldimethylammoniumchloride in mice; AUTHOR=MW Gill, SJ Hermansky, CL Wagner; EXTERNAL_SOURCE_ID=6027; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710609_15710610_15710611_15710612:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5b389a29b24cb4ca3d7a59c80f68199 |
| ToxValDB_ToxRefDB | NEL | =41 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gill, MW, JS Chun, & CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; TITLE=Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats; AUTHOR=Gill, MW, JS Chun, & CL Wagner; EXTERNAL_SOURCE_ID=6028; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-infiltration cellular|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-lymph node-hemorrhage|systemic: pathology microscopic-lymph node-hemosiderosis|systemic: pathology microscopic-lymph node-histiocytosis|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710613_15710614_15710615_15710616:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7b8abfb0617c480327a6ef1a1a57fc9 |
| ToxValDB_ToxRefDB | NEL | =32 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gill, MW, JS Chun, & CL Wagner. 1991. Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats. Bushy Run Research Center, Study no. 53-566. MRID 41965101.; TITLE=Chronic dietary toxicity/oncogenicity study with decyldimethylammoniumchloride in rats; AUTHOR=Gill, MW, JS Chun, & CL Wagner; EXTERNAL_SOURCE_ID=6028; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-lymph node-hemorrhage|systemic: pathology microscopic-lymph node-hemosiderosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-lymph node-histiocytosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710617_15710618_15710619_15710620:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2134ba9f5f82f9078493fb47ff1b2cfa |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | JXN40O9Y9B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C22H48N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JXN40O9Y9B"} |
| openFDA substances | FDA UNII substance identifier | JXN40O9Y9B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C22H48N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JXN40O9Y9B"} |
| openFDA substances | FDA UNII substance identifier | JXN40O9Y9B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C22H48N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JXN40O9Y9B"} |
| openFDA substances | FDA UNII substance identifier | JXN40O9Y9B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C22H48N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JXN40O9Y9B"} |