Is Didecyldimonium Chloride safe in cosmetics?
Didecyldimonium Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 7 toxicological study endpoint(s) are available in our database.
Didecyldimonium Chloride
Also known as: Didecyl dimethyl ammonium chloride (1-Decanaminium, N-decyl-N,N-dimethyl-, chloride) (DDAC), AMMONIUM CHLORIDE, N,N-DIDECYL-N,N-DIMETHYL-, DDAC C10-C10, Aliquat 203, Bio-dac 50-22 (+7 more)
INCI: DIDECYLDIMONIUM CHLORIDE
Didecyldimonium Chloride (CAS 7173-51-5) is a cosmetic cosmetic ingredient functioning as Antistatic, Emulsifying, Hair Conditioning, Surfactant. Reported NOAEL =117 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7173-51-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Didecyldimonium Chloride is classified GHS Danger (H301, H302, H314, H318, H400, H410, H411, H317) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic, Emulsifying, Hair Conditioning, Surfactant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
didecyl(dimethyl)azanium chloride
InChIKey
RUPBZQFQVRMKDG-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR report. No SCCS opinion. Biocidal active under BPR (approved Feb 2024-Jan 2034).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Didecyldimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Didecyldimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =117 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =130 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =165 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =220 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =260 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =425 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Under investigation
Evidence: Limited
(2026)
Health effects: Yes
Affected pathways: Thyroid
Regulatory framework: BPR
Source list: II
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
... The primary dermal effects that have been reported are rash, burning sensation, numbness, and itching. ... /Quaternary ammonium compounds/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Biocide
Emulsifier
Fragrance
Softener and conditioner
Surfactant (surface active agent)
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Didecyldimonium Chloride.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Didecyldimonium Chloride by CAS number or substance name.
Studies
7
Lowest NOAEL
117 mg/kg bw/day
Highest NOAEL
425 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Didecyl dimethyl ammonium chloride (1-Decanaminium, N-decyl-N,N-dimethyl-, chloride) (DDAC)
AMMONIUM CHLORIDE, N,N-DIDECYL-N,N-DIMETHYL-
DDAC C10-C10
Aliquat 203
Bio-dac 50-22
Caswell No. 331A
EINECS 230-525-2
EPA Pesticide Chemical Code 069149
Quaternium-12
UNII-JXN40O9Y9B
Dairyland brand chg teat dip
N-Decyl-N,N-dimethyl-1-decanaminium chloride
Chemical Function
Surfactant (surface active agent)
Biocide
Anti-static agent
Emulsifier
Softener and conditioner
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIDECYLDIMETHYLAMMONIUM CHLORIDE
ChEMBL ID
CHEMBL224987
Max Phase
-1
Frequently Asked Questions
Is Didecyldimonium Chloride allowed in the EU?
Didecyldimonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Didecyldimonium Chloride do in cosmetics?
Didecyldimonium Chloride functions as: Antistatic, Emulsifying, Hair Conditioning, Surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 7173-51-5.
What is the NOAEL for Didecyldimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Didecyldimonium Chloride is =117 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 7 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Didecyldimonium Chloride used outside cosmetics?
Didecyldimonium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Didecyldimonium Chloride have different safety status in cosmetics vs industrial chemicals?
Didecyldimonium Chloride is classified GHS Danger (H301, H302, H314, H318, H400, H410, H411, H317) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Didecyldimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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