Diethyl Ascorbic Acid

INCI: DIETHYL ASCORBIC ACID

CAS Number
277325-36-7
Function
Skin conditioning (vitamin C derivative / antioxidant)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Newer vitamin C derivative with limited published toxicological and clinical data compared to 3-O-Ethyl Ascorbic Acid. No standalone CIR or SCCS safety assessment; CPSR assessors should request supplier-held toxicological dossiers.

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Concern Level: Moderate

Frequently Asked Questions

Is Diethyl Ascorbic Acid safe in cosmetics?

Newer vitamin C derivative with limited published toxicological and clinical data compared to 3-O-Ethyl Ascorbic Acid. No standalone CIR or SCCS safety assessment; CPSR assessors should request supplier-held toxicological dossiers. The EU classifies Diethyl Ascorbic Acid as "permitted". Safety rating: MODERATE.

Is Diethyl Ascorbic Acid allowed in the EU?

Diethyl Ascorbic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethyl Ascorbic Acid do in cosmetics?

Diethyl Ascorbic Acid functions as: Skin conditioning (vitamin C derivative / antioxidant). It is classified as a cosmetic ingredient in our database. CAS number: 277325-36-7.

What is the Margin of Safety for Diethyl Ascorbic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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