NOAEL Studies Cosmetic Ingredient

Diethyl Malonate NOAEL Studies

CAS: 105-53-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 36 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 63.2737783355979 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7946; RecordID=ERPathway2016_454; DatasetName=ERPathway2016; DTXSID=DTXSID7021863; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=63.2737783355979; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE endocrine ACC 58.1780661624925 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7947; RecordID=ERPathway2016_454; DatasetName=ERPathway2016; DTXSID=DTXSID7021863; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=58.1780661624925; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7942; RecordID=ARPathway2016_457; DatasetName=ARPathway2016; DTXSID=DTXSID7021863; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE endocrine Model Score 0.00416 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7948; RecordID=ERPathway2016_454; DatasetName=ERPathway2016; DTXSID=DTXSID7021863; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00416; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE skin sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2751; Record_ID=skin_sensitization_invivo_732; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021863; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80102-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE skin sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2750; Record_ID=skin_sensitization_invivo_732; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021863; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80102-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE skin sensitization Induction dose per skin area 20000 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2754; Record_ID=skin_sensitization_invivo_733; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021863; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=20000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2018; 30149112; 10.1016/j.fct.2018.08.059; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2753; Record_ID=skin_sensitization_invivo_732; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021863; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80102-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
NTP ICE skin sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2757; Record_ID=skin_sensitization_invivo_733; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021863; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2018; 30149112; 10.1016/j.fct.2018.08.059; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021863
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =8.468 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631198:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32d7dca9a524721a0937157362bb3c16
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 53A58PA183 UNII - - - chemical -