NOAEL Studies
Cosmetic Ingredient
Diethyl Phthalate (DEP) NOAEL Studies
INCI: DIETHYL PHTHALATE
CAS: 84-66-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =1753 | mg/kg/day | Rat (F-344; M) | oral | short-term; 3 weeks | short-term | ATSDR MRLs; row_hash=346b7bad77ab5ac0; source_hash=ToxValhc_3cb2362f30ca74d4bc22092fdecc5585; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=1753; raw_unit=mg/kg/day; method=diet; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Moody DE, Reddy JK. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol 45(2):497-504.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83 |
| Regulatory source | LOAEL | =2000 | mg/kg/day | Rat (Wistar; M) | oral | short-term; 2 days | short-term | ATSDR MRLs; row_hash=1a6d32284b69cf87; source_hash=ToxValhc_2cf6bb503752389045528565c1b0f3a4; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=2000; raw_unit=mg/kg/day; method=gavage; effect=reproductive; effect_category=reproduction; file=toxval_ATSDR_MRLs.xlsx; long_ref=Jones HB, Garside DA, Liu R, et al. 1993. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Experimental and Molecular Pathology 58:179-193.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83 |
| Regulatory source | NOAEL | =750 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=2618951401a7ab06; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 7.50e2 mg/kg-day; system=Other; basis=Decreased growth rate, food consumption and altered organ weights; point_of_departure=NOAEL : 7.50e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID7021780; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0226_summary.pdf |
| Regulatory source | RfD | =0.8 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=fc5da510cca77db7; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=8e-1; system=Other; basis=Decreased growth rate, food consumption and altered organ weights; point_of_departure=NOAEL : 7.50e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID7021780; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0226_summary.pdf |
| Regulatory source | - | =0.25 | % | rat | oral | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 0.25; DOSE=xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.; EFFECT=xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co; CITATION=Ref.: 24, 69, 75, 109 2; CITATION_NUMBERS=[24,69,75,109,2]; REFERENCE=Ref.: 24, 69, 75, 109 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 24, 69, 75, 109 2","dose":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.","duration":"","effect":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"= 0.25","page":18,"route":"oral","species":"rat","study_id":"out168_en_noael_005"} |
| Regulatory source | - | 0.25 | % | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=0.25; DOSE=NOAEL for maternal toxicity | = | 0.25% DEP equal to 200 mg/kg; EFFECT=Visible table on page 18: NOAEL for maternal toxicity | = | 0.25% DEP equal to 200 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOAEL for maternal toxicity | = | 0.25% DEP equal to 200 mg/kg","duration":"","effect":"Visible table on page 18: NOAEL for maternal toxicity | = | 0.25% DEP equal to 200 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"0.25","page":18,"route":"","species":"","study_id":"out168_en_noael_020"} |
| Regulatory source | - | >2.5 | % | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=> 2.5; DOSE=NOEL F0 generation | > 2.5 % DEP | equivalent to | > 4400 mg/kg; EFFECT=Visible table on page 18: NOEL F0 generation | > 2.5 % DEP | equivalent to | > 4400 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOEL F0 generation | > 2.5 % DEP | equivalent to | > 4400 mg/kg","duration":"","effect":"Visible table on page 18: NOEL F0 generation | > 2.5 % DEP | equivalent to | > 4400 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"> 2.5","page":18,"route":"","species":"","study_id":"out168_en_noael_022"} |
| Regulatory source | - | <2.5 | % | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=< 2.5; DOSE=NOAEL F1 generation | < 2.5 % DEP | equivalent to | < 4400 mg/kg; EFFECT=Visible table on page 18: NOAEL F1 generation | < 2.5 % DEP | equivalent to | < 4400 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOAEL F1 generation | < 2.5 % DEP | equivalent to | < 4400 mg/kg","duration":"","effect":"Visible table on page 18: NOAEL F1 generation | < 2.5 % DEP | equivalent to | < 4400 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"< 2.5","page":18,"route":"","species":"","study_id":"out168_en_noael_023"} |
| Regulatory source | - | =5 | % | rat | oral | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 5; DOSE=ody-weight gain and decreased water consumption, being statistically significant at the highest dose.; EFFECT=ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur; CITATION=Ref.: 24, 69, 75, 109 2; CITATION_NUMBERS=[24,69,75,109,2]; REFERENCE=Ref.: 24, 69, 75, 109 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 24, 69, 75, 109 2","dose":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose.","duration":"","effect":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"= 5","page":18,"route":"oral","species":"rat","study_id":"out168_en_noael_006"} |
| Regulatory source | - | 5 | % | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=5; DOSE=NOAEL for foetal toxicity | = | 5% DEP equal to 4000 mg/kg; EFFECT=Visible table on page 18: NOAEL for foetal toxicity | = | 5% DEP equal to 4000 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOAEL for foetal toxicity | = | 5% DEP equal to 4000 mg/kg","duration":"","effect":"Visible table on page 18: NOAEL for foetal toxicity | = | 5% DEP equal to 4000 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"5","page":18,"route":"","species":"","study_id":"out168_en_noael_021"} |
| Regulatory source | - | 150 | mg /kg bw | rat | oral | 16 week | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=150; DOSE=No observed adverse effect level (rat, oral, 16 week) | NOAEL | 150 mg /kg bw; EFFECT=CALCULATION OF THE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent): No observed adverse effect level (rat, oral, 16 week) | NOAEL | 150 mg /kg bw; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"No observed adverse effect level (rat, oral, 16 week) | NOAEL | 150 mg /kg bw","duration":"16 week","effect":"CALCULATION OF THE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent): No observed adverse effect level (rat, oral, 16 week) | NOAEL | 150 mg /kg bw","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"mg /kg bw","noael_value":"150","page":28,"route":"oral","species":"rat","study_id":"out168_en_noael_024"} |
| Regulatory source | - | <500 | mg/kg | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=< 500; DOSE=NOAEL for maternal toxicity | = | < 500 mg/kg; EFFECT=Visible table on page 17: NOAEL for maternal toxicity | = | < 500 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOAEL for maternal toxicity | = | < 500 mg/kg","duration":"","effect":"Visible table on page 17: NOAEL for maternal toxicity | = | < 500 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"< 500","page":17,"route":"","species":"","study_id":"out168_en_noael_018"} |
| Regulatory source | - | 1600 | mg/kg | - | - | - | - | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=1600; DOSE=NOAEL for foetal toxicity | = | 1600 mg/kg; EFFECT=Visible table on page 17: NOAEL for foetal toxicity | = | 1600 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"NOAEL for foetal toxicity | = | 1600 mg/kg","duration":"","effect":"Visible table on page 17: NOAEL for foetal toxicity | = | 1600 mg/kg","endpoint":"","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"1600","page":17,"route":"","species":"","study_id":"out168_en_noael_019"} |
| Regulatory source | carcinogenicity | 350 | mg/kg | rat | - | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=350; DOSE=Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).; EFFECT=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","duration":"chronic","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"350","page":23,"route":"","species":"rat","study_id":"out168_en_noael_010"} |
| Regulatory source | carcinogenicity | 514 | mg/kg | mouse | - | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=514; DOSE=sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.; EFFECT=sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.","duration":"chronic","effect":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"514","page":25,"route":"","species":"mouse","study_id":"out168_en_noael_012"} |
| Regulatory source | carcinogenicity | 1000 | mg/kg | rat | - | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=1000; DOSE=Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).; EFFECT=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","duration":"chronic","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"1000","page":23,"route":"","species":"rat","study_id":"out168_en_noael_009"} |
| Regulatory source | carcinogenicity | 1057 | mg/kg | mouse | - | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=1057; DOSE=noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.; EFFECT=noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.","duration":"chronic","effect":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"1057","page":25,"route":"","species":"mouse","study_id":"out168_en_noael_011"} |
| Regulatory source | carcinogenicity | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 1250; DOSE=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:; EFFECT=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of; CITATION=Ref.: 59, 70, 77 2; CITATION_NUMBERS=[59,70,77,2]; REFERENCE=Ref.: 59, 70, 77 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","duration":"chronic","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"= 1250","page":27,"route":"oral","species":"rat","study_id":"out168_en_noael_013"} |
| Regulatory source | carcinogenicity | 2500 | mg/kg | rat | oral | chronic | carcinogenicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=2500; DOSE=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:; EFFECT=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once; CITATION=Ref.: 59, 70, 77 2; CITATION_NUMBERS=[59,70,77,2]; REFERENCE=Ref.: 59, 70, 77 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","duration":"chronic","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once","endpoint":"carcinogenicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"2500","page":27,"route":"oral","species":"rat","study_id":"out168_en_noael_014"} |
| Regulatory source | dermal absorption | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 150; DOSE=Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...; EFFECT=HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e; CITATION=(Ref.115); CITATION_NUMBERS=[115]; REFERENCE=(Ref.115); DETAILS_JSON={"cas_number":"84-66-2","citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","duration":"16 week","effect":"HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e","endpoint":"dermal absorption","ingredient":"codes","loael_value":"","noael_unit":"mg /kg bw","noael_value":"= 150","page":28,"route":"oral","species":"rat","study_id":"out168_en_noael_015"} |
| Regulatory source | dermal absorption | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 150; DOSE=Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...; EFFECT=alate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as ethanol; CITATION=(Ref.115); CITATION_NUMBERS=[115]; REFERENCE=(Ref.115); DETAILS_JSON={"cas_number":"84-66-2","citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","duration":"16 week","effect":"alate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as ethanol","endpoint":"dermal absorption","ingredient":"codes","loael_value":"","noael_unit":"mg /kg bw","noael_value":"= 150","page":28,"route":"oral","species":"rat","study_id":"out168_en_noael_016"} |
| Regulatory source | dermal absorption | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 150; DOSE=Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...; EFFECT=vent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as ethanol denaturant at a maximum concentration of 1% (hypothetic usag; CITATION=(Ref.115); CITATION_NUMBERS=[115]; REFERENCE=(Ref.115); DETAILS_JSON={"cas_number":"84-66-2","citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","duration":"16 week","effect":"vent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as ethanol denaturant at a maximum concentration of 1% (hypothetic usag","endpoint":"dermal absorption","ingredient":"codes","loael_value":"","noael_unit":"mg /kg bw","noael_value":"= 150","page":28,"route":"oral","species":"rat","study_id":"out168_en_noael_017"} |
| Regulatory source | developmental toxicity | <500 | mg/kg | - | - | - | developmental toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=< 500; DOSE=ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.; EFFECT=ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","duration":"","effect":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","endpoint":"developmental toxicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"< 500","page":17,"route":"","species":"","study_id":"out168_en_noael_003"} |
| Regulatory source | developmental toxicity | =1600 | mg/kg | - | - | - | developmental toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 1600; DOSE=by reduced thymus and spleen weights and at the high dose by increased adrenal weight.; EFFECT=by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","duration":"","effect":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","endpoint":"developmental toxicity","ingredient":"codes","loael_value":"","noael_unit":"mg/kg","noael_value":"= 1600","page":17,"route":"","species":"","study_id":"out168_en_noael_004"} |
| Regulatory source | repeated dose toxicity | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 0.2; DOSE=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).; EFFECT=SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi; CITATION=Ref.: 3, 10 2; CITATION_NUMBERS=[3,10,2]; REFERENCE=Ref.: 3, 10 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 3, 10 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","duration":"Sub-chronic","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi","endpoint":"repeated dose toxicity","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"= 0.2","page":10,"route":"oral","species":"rat","study_id":"out168_en_noael_001"} |
| Regulatory source | repeated dose toxicity | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT== 0.2; DOSE=Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).; EFFECT=Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maximum volume for mous; CITATION=Ref.: 3, 10 2; CITATION_NUMBERS=[3,10,2]; REFERENCE=Ref.: 3, 10 2; DETAILS_JSON={"cas_number":"84-66-2","citation":"Ref.: 3, 10 2","dose":"Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","duration":"Sub-chronic","effect":"Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maximum volume for mous","endpoint":"repeated dose toxicity","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"= 0.2","page":10,"route":"oral","species":"rat","study_id":"out168_en_noael_002"} |
| Regulatory source | reproductive toxicity | >2.5 | % | - | - | - | reproductive toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=> 2.5; DOSE=In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.; EFFECT=ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","duration":"","effect":"ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","endpoint":"reproductive toxicity","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"> 2.5","page":18,"route":"","species":"","study_id":"out168_en_noael_007"} |
| Regulatory source | reproductive toxicity | <2.5 | % | - | - | - | reproductive toxicity | SOURCE_SUBDIR=out168_en; REPORT_TITLE=OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING DIETHYL PHTHALATE; OPINION_NUMBER=SCCNFP/0411/01; COMMITTEE=SCCNFP; REPORT_DATE=4 June 2002; VALUE_TEXT=< 2.5; DOSE=In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.; EFFECT=in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"84-66-2","citation":"","dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","duration":"","effect":"in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","endpoint":"reproductive toxicity","ingredient":"codes","loael_value":"","noael_unit":"%","noael_value":"< 2.5","page":18,"route":"","species":"","study_id":"out168_en_noael_008"} |
WHO/JECFA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =3640 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=2a6f05afb0c6723b; raw_unit=mg/kg body weight per day; context=The LOAEL in this study is estimated to be 3640 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=1410f45afe019d4f; raw_unit=mg/kg body weight per day; context=Therefore, the dose of 1.0% (750 mg/kg body weight per day) is considered to be the NOAEL. |
| WHO/JECFA | NOAEL | =1600 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=53be2a9ea00d928c; raw_unit=mg/kg body weight per day; context=A tolerable intake of 5 mg/kg body weight was estimated from a NOAEL of 1600 mg/kg body weight per day for developmental effects to which an uncertainty factor of 300 was applied. |
| WHO/JECFA | NOAEL | =1900 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=de04bbd5bbe6496d; raw_unit=mg/kg body weight per day; context=The dose of 1900 mg/kg body weight per day (2.5% in the diet) was identified as the NOAEL both for the mother and for the offspring. |
| WHO/JECFA | NOAEL | =1900 | mg/kg bw | Rat | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=5f04b90c3d4c6fa2; raw_unit=mg/kg; context=La dose sans effet nocif observable (NOAEL) était respectivement égale à 1600 et à 1900 mg/kg de poids corporel par jour pour la souris et le rat. |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >4.64 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3901; Record_ID=acute_inhalation_3586; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.64; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =8600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_10834; row=11708; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >9200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10835; row=11706; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <9500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10836; row=11707; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 42.5 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2763; Record_ID=adme_parameters_689; Data_Type=Measured; DTXSID=DTXSID7021780; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=42.5; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE adme parameters | Fu | 0.19 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2764; Record_ID=adme_parameters_689; Data_Type=Measured; DTXSID=DTXSID7021780; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.19; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 37 | mg/animal/day | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=8001; Record_ID=cancer_4471; Data_Type=In Vivo; Formulation_Name=Diethyl Phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=37; Response_Unit=mg/animal/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Reference=TR-429; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr429/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE cancer | Top dose | 369 | mg/animal/day | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7999; Record_ID=cancer_4472; Data_Type=In Vivo; Formulation_Name=Diethyl Phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=369; Response_Unit=mg/animal/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Dermal; Reference=TR-429; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr429/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7934; RecordID=ARPathway2016_1639; DatasetName=ARPathway2016; DTXSID=DTXSID7021780; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE skin irritation 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability | 55.4 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4702; Record_ID=skin_irritation_invitro_1287; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=55.4; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 72.4 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4699; Record_ID=skin_irritation_invitro_1292; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=72.40; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 72.7 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4698; Record_ID=skin_irritation_invitro_1294; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=72.7; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 73.8 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4697; Record_ID=skin_irritation_invitro_1310; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=73.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 75.04 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4696; Record_ID=skin_irritation_invitro_1311; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=75.04; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 86.6 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4680; Record_ID=skin_irritation_invitro_1268; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=86.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 87.8 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4679; Record_ID=skin_irritation_invitro_1271; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=87.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 88 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4678; Record_ID=skin_irritation_invitro_1273; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=88; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 92.54 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4677; Record_ID=skin_irritation_invitro_1275; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=92.54; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 95.31 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4676; Record_ID=skin_irritation_invitro_1277; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=95.31; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 98 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4675; Record_ID=skin_irritation_invitro_1279; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 98.9 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4673; Record_ID=skin_irritation_invitro_1281; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=98.9; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 99.22 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4672; Record_ID=skin_irritation_invitro_1283; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=99.22; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 102.15 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4703; Record_ID=skin_irritation_invitro_1285; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=102.15; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 103.1 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4701; Record_ID=skin_irritation_invitro_1289; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.1; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 104.3 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4700; Record_ID=skin_irritation_invitro_1291; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=104.3; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE skin sensitization 48 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 296.57 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2521; Record_ID=skin_sensitization_invitro_605; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=296.57; Reported_Response_Unit=ug/mL; Response=296.57; Response_Unit=ug/mL; Reference=Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Ashikaga and Sakaguchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD54, EC200 | 296.6 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2269; Record_ID=skin_sensitization_invitro_549; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=296.60000000000002; Reported_Response_Unit=ug/mL; Response=296.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD86, EC150 | 121.04 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8692; Record_ID=skin_sensitization_invitro_2407; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=121.04; Reported_Response_Unit=ug/mL; Response=121.04; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD86, EC150 | >1555.68 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8147; Record_ID=skin_sensitization_invitro_2170; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=222.24; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1555.68; Converted_Response_Unit=ug/mL; Response=1555.68; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8696; Record_ID=skin_sensitization_invitro_2407; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CV75 | 600 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2271; Record_ID=skin_sensitization_invitro_549; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CV75; Reported_Response=600; Reported_Response_Unit=ug/mL; Response=600; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Cys | 0.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=462; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.2; Reported_Response_Unit=%; Response=0.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Cys | 0.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=455; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys | -0.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=454; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.7; Reported_Response_Unit=%; Response=-0.7; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys | 2.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=460; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=457; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 1.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=389; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.4; Reported_Response_Unit=%; Response=1.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 59.97 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6723; Record_ID=skin_sensitization_invitro_1596; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=59.97; Reported_Response_Unit=uM; Response=59.97; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 183.54 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6720; Record_ID=skin_sensitization_invitro_1586; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=183.54; Reported_Response_Unit=uM; Response=183.54; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | <516.41 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7946; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=516.41; Reported_Response_Unit=uM; Response=516.41; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 582.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6722; Record_ID=skin_sensitization_invitro_1588; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=582.70000000000005; Reported_Response_Unit=uM; Response=582.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 913.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6724; Record_ID=skin_sensitization_invitro_1585; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=913.7; Reported_Response_Unit=uM; Response=913.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 1180.53 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6719; Record_ID=skin_sensitization_invitro_1587; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1180.53; Reported_Response_Unit=uM; Response=1180.53; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6721; Record_ID=skin_sensitization_invitro_1589; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | IC50 | >1285 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7627; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1285; Reported_Response_Unit=uM; Response=1285; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | IC50 | 1879.05 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6747; Record_ID=skin_sensitization_invitro_1604; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1879.05; Reported_Response_Unit=uM; Response=1879.05; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.047 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6791; Record_ID=skin_sensitization_invitro_1600; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0469999999999999; Reported_Response_Unit=Unitless; Response=1.047; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.049 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6794; Record_ID=skin_sensitization_invitro_1603; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0489999999999999; Reported_Response_Unit=Unitless; Response=1.049; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.07 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6796; Record_ID=skin_sensitization_invitro_1589; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.07; Reported_Response_Unit=Unitless; Response=1.07; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.081 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6798; Record_ID=skin_sensitization_invitro_1604; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.081; Reported_Response_Unit=Unitless; Response=1.081; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.088 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6801; Record_ID=skin_sensitization_invitro_1601; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0880000000000001; Reported_Response_Unit=Unitless; Response=1.088; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6803; Record_ID=skin_sensitization_invitro_1590; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.113 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6804; Record_ID=skin_sensitization_invitro_1591; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.113; Reported_Response_Unit=Unitless; Response=1.113; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.132 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6806; Record_ID=skin_sensitization_invitro_1595; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1319999999999999; Reported_Response_Unit=Unitless; Response=1.132; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.138 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6808; Record_ID=skin_sensitization_invitro_1594; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1379999999999999; Reported_Response_Unit=Unitless; Response=1.138; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.192 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6810; Record_ID=skin_sensitization_invitro_1593; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1919999999999999; Reported_Response_Unit=Unitless; Response=1.192; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6812; Record_ID=skin_sensitization_invitro_1605; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.327 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6816; Record_ID=skin_sensitization_invitro_1592; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.327; Reported_Response_Unit=Unitless; Response=1.327; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.391 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6818; Record_ID=skin_sensitization_invitro_1598; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.391; Reported_Response_Unit=Unitless; Response=1.391; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.4 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6820; Record_ID=skin_sensitization_invitro_1607; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.427 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6821; Record_ID=skin_sensitization_invitro_1602; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.427; Reported_Response_Unit=Unitless; Response=1.427; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.534 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6823; Record_ID=skin_sensitization_invitro_1585; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.534; Reported_Response_Unit=Unitless; Response=1.534; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.656 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6825; Record_ID=skin_sensitization_invitro_1587; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.6559999999999999; Reported_Response_Unit=Unitless; Response=1.656; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.7 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6826; Record_ID=skin_sensitization_invitro_1608; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7; Reported_Response_Unit=Unitless; Response=1.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.808 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6827; Record_ID=skin_sensitization_invitro_1597; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.8080000000000001; Reported_Response_Unit=Unitless; Response=1.808; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.9 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6828; Record_ID=skin_sensitization_invitro_1588; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9; Reported_Response_Unit=Unitless; Response=1.9; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.999 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6829; Record_ID=skin_sensitization_invitro_1599; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9990000000000001; Reported_Response_Unit=Unitless; Response=1.999; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 2.047 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6830; Record_ID=skin_sensitization_invitro_1596; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.0470000000000002; Reported_Response_Unit=Unitless; Response=2.047; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 2.522 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6832; Record_ID=skin_sensitization_invitro_1586; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.5219999999999998; Reported_Response_Unit=Unitless; Response=2.522; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 3.369 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7523; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=Imax; Reported_Response=3.369076721; Reported_Response_Unit=Unitless; Response=3.369; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10722; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Induction dose per skin area | 6207 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10720; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10726; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
SCCNFP Opinion 52 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | {"citation":"Ref.: 3, 10 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi","page":10,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_001"} |
| SCCNFP Opinion | NOAEL | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | {"citation":"Ref.: 3, 10 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi","page":10,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_001"} |
| SCCNFP Opinion | NOAEL | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | {"citation":"Ref.: 3, 10 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi","page":10,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_001"} |
| SCCNFP Opinion | NOAEL | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | {"citation":"Ref.: 3, 10 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 10 caecum) in male and or female rats was also noted at the two highest concentrations (corresponding to 750 and 3710 mg/kg/day). At 0.2% concentration, the increase in the relative liver weight in females is slight and the significance is at p < 0.05. In the absence of a clear liver toxicity after long-term studies in mice and rats (see paragraph 2.9) we can establish the NOAEL as follows: NOAEL = 0.2% concentration in the diet (corresponding to 150 mg/kg/day). The microsomal carboxylesterase activities in tissue of Clofibrate-fed mice and rats are altered by DEP confirming it as a peroxisome proliferator. Ref.: 3, 10 2.3.7. Sub-chronic dermal toxicity Mouse In a 4-week study, groups of 10 male and 10 female B6C3F1 mice received dermally DEP, at volumes of 0, 12.5, 25, 50 or 100 µl (0, 15, 31, 62 and 123 µg/kg), applied neat, 5 days/week. 100 µl can be considered as a reasonable maxi","page":10,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_001"} |
| SCCNFP Opinion | NOAEL | =0.25 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_005"} |
| SCCNFP Opinion | NOAEL | =0.25 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_005"} |
| SCCNFP Opinion | NOAEL | =0.25 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_005"} |
| SCCNFP Opinion | NOAEL | =0.25 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"xicity was shown by decreased food consumption, decreased body-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at co","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_005"} |
| SCCNFP Opinion | NOAEL | >2.5 | % | - | - | - | reproductive toxicity | {"dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","effect":"ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_007"} |
| SCCNFP Opinion | NOAEL | >2.5 | % | - | - | - | reproductive toxicity | {"dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","effect":"ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_007"} |
| SCCNFP Opinion | NOAEL | >2.5 | % | - | - | - | reproductive toxicity | {"dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","effect":"ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_007"} |
| SCCNFP Opinion | NOAEL | >2.5 | % | - | - | - | reproductive toxicity | {"dose":"In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain.","effect":"ysed separately), decreased sperm concentration (no change in sperm motility or percentage of abnormal sperm), increased prostate weight, increased liver weight in females, and reduced uterus and pituitary weight. There were no statistically significant effects on mating behaviour, proportion of pups born alive, live pup weight or sex of pups born alive. In summary, effects on general reproductive performance with DEP were limited only at the F1 generation to changes at a dose causing decreased body weight gain. NOEL F0 generation > 2.5 % DEP equivalent to > 4400 mg/kg NOAEL F1 generation < 2.5 % DEP equivalent to < 4400 mg/kg","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_007"} |
| SCCNFP Opinion | NOAEL | =5 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_006"} |
| SCCNFP Opinion | NOAEL | =5 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_006"} |
| SCCNFP Opinion | NOAEL | =5 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_006"} |
| SCCNFP Opinion | NOAEL | =5 | % | rat | oral | - | NOAEL study | {"citation":"Ref.: 24, 69, 75, 109 2","dose":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose.","effect":"ody-weight gain and decreased water consumption, being statistically significant at the highest dose. Gravid uterine weight, absolute and relative maternal liver and kidney weights were unaffected by DEP treatment. No adverse effect on embryo/foetal growth, viability or incidence of external, visceral or skeletal malformations was observed. An increased incidence of one extra rib in the offspring from rats in the maternally toxic high dose group was seen. NOAEL for maternal toxicity = 0.25% DEP equal to 200 mg/kg NOAEL for foetal toxicity = 5% DEP equal to 4000 mg/kg Conclusion DEP administered to pregnant rats during the period of major organo-genesis had no adverse effect upon embryo/foetal development. The only effect noted was an increase in the incidence of extra rib (a commonly observed variation) at a maternally toxic exposure level. Ref.: 24, 69, 75, 109 2.6.1. One-generation reproduction toxicity Oral route mice Male and female CD-1 mice were given DEP at concentrations of 0.25, 1.25 or 2.5% in the diet, before, dur","page":18,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_006"} |
| SCCNFP Opinion | NOAEL | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | {"citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","effect":"HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e","page":28,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_015"} |
| SCCNFP Opinion | NOAEL | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | {"citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","effect":"HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e","page":28,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_015"} |
| SCCNFP Opinion | NOAEL | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | {"citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","effect":"HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e","page":28,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_015"} |
| SCCNFP Opinion | NOAEL | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | {"citation":"(Ref.115)","dose":"Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of...","effect":"HE MARGIN OF SAFETY (Diethylphthalate) (Cosmetic products/ ethanol denaturant/ fragrance solvent) Because of the wide spread use of Diethyl phthalate, the SCCNFP made a worst case calculation. Based on a usage volume of 10 ml, containing at maximum 10%: Maximum amount of ingredient applied I (mg) = 1120 mg Typical body weight of human = 60 kg Maximum absorption through the skin A (%) = 5% (Human skin in vitro) Dermal absorption per treatment I x A = 56 mg/day Systemic exposure dose (SED) I x A/60 kg = 0.93 mg No observed adverse effect level NOAEL = 150 mg /kg bw (rat, oral, 16 week) Margin of Safety NOAEL / SED = 161 These data have to be compared to the results published in 2001 (Ref.115), referring to a paper mentioning a survey on more than 2000 perfumes compounds intended for hydro-alcoholic cosmetics, and reported a 97.5 percentile of use for DEP of 28.6%. The author concluded to a potential exposure of approximately of 44 mg/day corresponding to 0.73 mg/kg/day, giving a MOS of 205. Other examples Ethanol denaturant DEP can also be used as e","page":28,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_015"} |
| SCCNFP Opinion | NOAEL | =350 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_010"} |
| SCCNFP Opinion | NOAEL | =350 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_010"} |
| SCCNFP Opinion | NOAEL | =350 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_010"} |
| SCCNFP Opinion | NOAEL | =350 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen at the site of application. An interim evaluation with sacrifice of 10 animals of each sex was done at 15 months. The survival rate p","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_010"} |
| SCCNFP Opinion | NOAEL | <500 | mg/kg | - | - | - | developmental toxicity | {"dose":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_003"} |
| SCCNFP Opinion | NOAEL | <500 | mg/kg | - | - | - | developmental toxicity | {"dose":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_003"} |
| SCCNFP Opinion | NOAEL | <500 | mg/kg | - | - | - | developmental toxicity | {"dose":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_003"} |
| SCCNFP Opinion | NOAEL | <500 | mg/kg | - | - | - | developmental toxicity | {"dose":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"ernal toxicity was evidenced at all doses by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_003"} |
| SCCNFP Opinion | NOAEL | =514 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.","effect":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_012"} |
| SCCNFP Opinion | NOAEL | =514 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.","effect":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_012"} |
| SCCNFP Opinion | NOAEL | =514 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.","effect":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_012"} |
| SCCNFP Opinion | NOAEL | =514 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity.","effect":"sms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoylphorbol-13-acetate) or to promote tumorigenesis following administration of a known initiator (DMBA: 7,12-dimethylbenz (a)anthracene).","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_012"} |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_009"} |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_009"} |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_009"} |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg | rat | - | chronic | carcinogenicity | {"dose":"Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g).","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 23 Kerato-acanthoma: 1/49 (controls), 1/50 (100 µl), 0/51 (300 µl) Face papilloma: 1/51 (300 µl) Lip papilloma: 1/51 (300 µl) Thoracic, kerato-acanthoma: 1/51 (300 µl). Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 300 µl per a rat (corresponding in mean to 1000 mg/kg for a rat of 350 g); - for chronic effects, the NOAEL is equal to 100 µl per rat (corresponding in mean to 350 mg/kg for a rat of 350 g). Mice were treated dermally with DEP doses of 0, 7.5, 15 or 30 µl (approximately 0, 9, 18 and 37 mg/ per animal). For each dose DEP was diluted in 100 µl acetone. The treatment was done five days /week for up to 103 weeks with a week recovery. No significant evidence of toxicity or neoplasia was seen a","page":23,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_009"} |
| SCCNFP Opinion | NOAEL | =1057 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.","effect":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_011"} |
| SCCNFP Opinion | NOAEL | =1057 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.","effect":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_011"} |
| SCCNFP Opinion | NOAEL | =1057 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.","effect":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_011"} |
| SCCNFP Opinion | NOAEL | =1057 | mg/kg | mouse | - | chronic | carcinogenicity | {"dose":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls.","effect":"noma or carcinoma was higher in low and mid-dose mice than in high-dose mice or controls. Because the incidence of hepatocellular neoplasms in the high-dose male mice was similar to the historical control mean, and because there was no dose response for liver neoplasms in female mice, these marginal increases were considered to be uncertain findings providing only equivocal evidence of carcinogenic activity. No other lesions or neoplasms showed a relation to treatment. Conclusion - for carcinogenic potential, the NOAEL is equal or higher than 30 µg/l per a mouse (corresponding in mean to 1057 mg/kg for a mouse of 35 g); - for chronic effects, the NOAEL is equal to 15 µl per male mouse and 30 µl per female mouse. These numbers correspond approximately to 514 mg/kg (males) and 1057 mg/kg (females) for a mouse of 35 g). A one-year initiation-promotion study in a group of 50 male mice was conducted to evaluate the potential of DEP applied dermally to initiate tumorigenesis when followed by a strong promoter (TPA: 12-O-tetradecanoy","page":25,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_011"} |
| SCCNFP Opinion | NOAEL | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_013"} |
| SCCNFP Opinion | NOAEL | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_013"} |
| SCCNFP Opinion | NOAEL | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_013"} |
| SCCNFP Opinion | NOAEL | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_013"} |
| SCCNFP Opinion | NOAEL | =1600 | mg/kg | - | - | - | developmental toxicity | {"dose":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_004"} |
| SCCNFP Opinion | NOAEL | =1600 | mg/kg | - | - | - | developmental toxicity | {"dose":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_004"} |
| SCCNFP Opinion | NOAEL | =1600 | mg/kg | - | - | - | developmental toxicity | {"dose":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_004"} |
| SCCNFP Opinion | NOAEL | =1600 | mg/kg | - | - | - | developmental toxicity | {"dose":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight.","effect":"by reduced thymus and spleen weights and at the high dose by increased adrenal weight. Foetal body weight was reduced significantly at the high dose and skeletal examinations showed a higher incidence of cervical and lumbar rib variations at the high dose. However, no external, visceral or skeletal anomalies in the foetuses were attributable to DEP treatment. The authors concluded that DEP has no potential to produce teratogenic effects on foetuses under these conditions. NOAEL for maternal toxicity = < 500 mg/kg NOAEL for foetal toxicity = 1600 mg/kg","page":17,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_004"} |
| SCCNFP Opinion | NOAEL | =2500 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_014"} |
| SCCNFP Opinion | NOAEL | =2500 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_014"} |
| SCCNFP Opinion | NOAEL | =2500 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_014"} |
| SCCNFP Opinion | NOAEL | =2500 | mg/kg | rat | oral | chronic | carcinogenicity | {"citation":"Ref.: 59, 70, 77 2","dose":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.:","effect":"SCCNFP/0411/01 Opinion on diethyl phthalate _____________________________________________________________________________________________ 27 NOAEL for chronic effect = 1250 mg/kg for both males and females NOAEL for carcinogenicity = ≥ 2500 mg/kg Ref.: 59, 70, 77 2.10. Estrogenic potential - DEP has not been reported to cause estrogenic activity in vertebrates, although weak activity has been reported in some in vitro studies. - EPA (1996) determined that there was insufficient evidence, at that time, to demonstrate that DEP causes hormonal disruption. Groups of ten immature (21-22 days old) female Wistar [Crl (WI) BR] rats received a single oral dose of 0 (vehicle control), 50, 150 or 500 mg/kg body weight of DEP once","page":27,"pdf":"out168_en.pdf","row_type":"noael_study","study_id":"out168_en_noael_014"} |
EPA ToxRefDB v3 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =0.031 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 4 week | SAC | study_id=5333; toxval_study_source_id=studyid5333_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.123 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5334; toxval_study_source_id=studyid5334_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|in life observation-clinical signs-scabbing|in life observation-mortality-mortality; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.184 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 4 week | SAC | study_id=5332; toxval_study_source_id=studyid5332_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight; dose_level=3; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =197 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-testosterone-testosterone|pathology gross-sperm measure-sperm morphology|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|organ weight-adrenal gland-absolute|organ weight-epididymis-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =222 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm morphology|organ weight-adrenal gland-relative to body weight|organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-seminal vesicle-relative to body weight|organ weight-prostate-absolute; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =325 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|organ weight-kidney-relative to body weight|in life observation-clinical signs-desquamation; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1150 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Juvenile_F1_M_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-pituitary gland-relative to body weight|organ weight-spleen-absolute|organ weight-adrenal gland-absolute|organ weight-thymus-absolute|organ weight-brain-relative to body weight|organ weight-thymus-relative to body weight|organ weight-liver-relative to body weight|in life observation-body weight-offspring (pup) weight; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1297 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1300 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|in life observation-clinical signs-desquamation; dose_level=3; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1375 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-uterus-absolute|organ weight-kidney-relative to body weight; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5334; toxval_study_source_id=studyid5334_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|pathology microscopic-skin-acanthosis|in life observation-clinical signs-scabbing; dose_level=0; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.015 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 4 week | SAC | study_id=5333; toxval_study_source_id=studyid5333_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.092 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 4 week | SAC | study_id=5332; toxval_study_source_id=studyid5332_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =40 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm morphology|organ weight-adrenal gland-absolute|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|clinical chemistry-testosterone-testosterone|organ weight-epididymis-absolute|organ weight-liver-relative to body weight; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =46 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_M_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-seminal vesicle-relative to body weight|organ weight-prostate-absolute|organ weight-adrenal gland-relative to body weight|pathology gross-sperm measure-sperm morphology; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =56 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F2_F_systemic; toxval_effect_list=organ weight-uterus-absolute|organ weight-uterus-relative to body weight; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =255 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =267 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-uterus-absolute|organ weight-liver-absolute|organ weight-kidney-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =650 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|in life observation-clinical signs-desquamation; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ATSDR MRLs 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =1753 | mg/kg bw/day | Rat | oral | short-term; 3 weeks | short-term | LONG_REF=Moody DE, Reddy JK. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol 45(2):497-504.; TITLE=Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds; AUTHOR=Moody DE; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp73.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447548:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3cb2362f30ca74d4bc22092fdecc5585 |
| ToxValDB ATSDR MRLs | LOAEL | =2000 | mg/kg bw/day | Rat | oral | short-term; 2 days | short-term | LONG_REF=Jones HB, Garside DA, Liu R, et al. 1993. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Experimental and Molecular Pathology 58:179-193.; TITLE=The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo; AUTHOR=Jones HB; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp73.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447547:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2cf6bb503752389045528565c1b0f3a4 |
| ToxValDB ATSDR MRLs | MRL | =6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=hepatic in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca0f8d71ff9dbf9a05469bd3be84ff77 |
| ToxValDB ATSDR MRLs | MRL | =6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=hepatic in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca0f8d71ff9dbf9a05469bd3be84ff77 |
| ToxValDB ATSDR MRLs | MRL | =7 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=reproductive in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ea317f15593346f7189556222bb9958 |
| ToxValDB ATSDR MRLs | MRL | =7 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=reproductive in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ea317f15593346f7189556222bb9958 |
ToxValDB Alaska DEC 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.72 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446182:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=266307f694c555e1087800e283b3fb78 |
| ToxValDB Alaska DEC | RfD | =0.72 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446182:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=266307f694c555e1087800e283b3fb78 |
| ToxValDB Alaska DEC | RfD | =0.8 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446183:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=433a0901915c1f6fc7281df5c0496b5a |
| ToxValDB Alaska DEC | RfD | =0.8 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446183:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=433a0901915c1f6fc7281df5c0496b5a |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =63627.3 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2023; ORIGINAL_YEAR=2023; STUDY_GROUP=DOE Protective Action Criteria:15514486:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66c68563ee268fda22d2a0ffd06e54de |
ToxValDB DOE Wildlife Benchmarks 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =4583 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511611:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a93b5781c1b09e2969bd6f2b15a20ae0 |
ECHA 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | >=1015 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217981; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818672:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac099091c8761cf19ca63d22d0e9966b |
| ECHA | LEL | >=1050 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217981; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818671:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c176839abde943c11cc1e26254b65f34 |
| ECHA | LEL | >=1100 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d21798b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818988:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_002574d3ca867dea833e2f180058dca4 |
| ECHA | LOAEL | =3640 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15859459_15859597:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34d69445e18090a95dea47642c5598cf |
| ECHA | NOAEL | =11.7 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc9d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/6/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15832201:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_adc75cec0ea9b0319a80275a06b8b8ad |
| ECHA | NOAEL | <500 | mg/kg bw/day | Mouse | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/3?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15822641:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58a23a9f1bec96308125a1ea6354ee35 |
| ECHA | NOAEL | =1600 | mg/kg bw/day | Mouse | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/3?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15821325:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44476bc55183232545c255b99a4c6deb |
| ECHA | NOAEL | =3000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21c9e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855397_15856218:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07ad52288a40da1cb71c4ab116c54af4 |
| ECHA | NOAEL | >4400 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba33f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15857663:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a360faa229c6fa3dea1efd4821ec240 |
| ECHA | NOAEL | =15000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21c9e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855397_15856218:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59959156aec030c4381e9e312b92b381 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.53(1): 35-41 Oishi,S., and K. Hiraga Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations 1980; TITLE=Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations; AUTHOR=Oishi,S., and K. Hiraga; DOI=10.1016/0041-008x(80)90378-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=66065; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content|Growth: Weight|Hormone(s): Dihydrotestosterone|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597152_15598243:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d2892a6d32328e03e4f9c8bfb56cbd9 |
| ToxValDB ECOTOX | NOEL | =4500 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Mortality: Survival|Growth: Weight|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15612052:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=59994231015f1cd7be6aadea377cf802 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =10.56 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631201:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee625aa23d3ae613fed55999e868b512 |
ToxValDB HPVIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.D. Brown, K. R. Butterworth, I. F. Gaunt, P. Grassom, and S. D. Gangolli. (1978). Short-term oral toxicity study of diethyl phthalate in the rat. Food and Cosmetic Toxicology, 16: 415-422.; QUALITY=1; EXTERNAL_SOURCE_ID=63163; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639370:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1982d77cad7f571ca8ebb85c05f80682 |
| ToxValDB HPVIS | NOAEL | =750 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.D. Brown, K. R. Butterworth, I. F. Gaunt, P. Grassom, and S. D. Gangolli. (1978). Short-term oral toxicity study of diethyl phthalate in the rat. Food and Cosmetic Toxicology, 16: 415-422.; QUALITY=1; EXTERNAL_SOURCE_ID=61317; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639167:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b3c25b58aa92997423801177f5a62c8d |
| ToxValDB HPVIS | NOAEL | =3210 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Field, et al. (1993). Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology, 38:33-44.; QUALITY=1; EXTERNAL_SOURCE_ID=58231; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642390:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd2db2b08a089b3e3fa7a51c7a6903e2 |
| ToxValDB HPVIS | NOAEL | =3250 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.J.C. Lamb, IV, R.E. Chapin, C.J. Teague, A.D. Lawton and J.R. Reel (1987). Reproductive effects of four phthalate acid esters in the mouse. Toxicology and Applied Pharmacology88:255-269.; QUALITY=2; EXTERNAL_SOURCE_ID=65159; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15643130:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fc3937fe7ef5ee2b855b2d61d45e41af |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =3160 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Brown, D., K.R. Butterworth, I.F. Gaunt, P. Grasso and S.D. Gangolli. 1978. Short-term oral toxicity study of diethyl phthalate in the rat. Food Cosmet. Toxicol. 16: 415-422.; TITLE=Short-term oral toxicity study of diethyl phthalate in the rat; AUTHOR=Brown, D., K.R. Butterworth, I.F. Gaunt, P. Grasso and S.D. Gangolli; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; TOXICOLOGICAL_EFFECT=reduced growth rate, food consumption and altered organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645071_15645073:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4a698363e6b3ececf5f50021ba34f458 |
ToxValDB ToxRefDB 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =0.031 | mg/kg bw/day | Mouse | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5333; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708987_15708988:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4bfa7caa6b3e2d6f6763249e33781187 |
| ToxValDB ToxRefDB | LEL | =0.123 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5334; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-scabbing|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB:15708989:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79335b92a5449b5a7386827f41f5b2b8 |
| ToxValDB ToxRefDB | LEL | =0.184 | mg/kg bw/day | Rat | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5332; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708983_15708984:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b095e4eb99fe9fab68c9b22f73983f09 |
| ToxValDB ToxRefDB | LEL | =197 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-testosterone-testosterone|systemic: pathology gross-sperm measure-sperm morphology|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: organ weight-liver-relative to body weight|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-epididymis-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685337_15685338_15685339_15685340:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f654a6ffad1ba5a954852e5419319a40 |
| ToxValDB ToxRefDB | LEL | =222 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm morphology|systemic: organ weight-prostate-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-seminal vesicle-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685343_15685344_15685345_15685346:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e6d7dc980fed419c4cea357775eaa41 |
| ToxValDB ToxRefDB | LEL | =325 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|organ weight; STUDY_GROUP=ToxRefDB:15708991:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1ea00ebcf33b54e7a429f9e72f2506e |
| ToxValDB ToxRefDB | LEL | =1150 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-thymus-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-pituitary gland-relative to body weight|systemic: organ weight-brain-relative to body weight|systemic: organ weight-spleen-absolute|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-body weight-offspring (pup) weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685353_15685354_15685355_15685356:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0df7b784dd9ce9c9668629e76755373 |
| ToxValDB ToxRefDB | LEL | =1297 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685333_15685334_15685335_15685336:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66ac4532bfc80d4b990f4903c864c245 |
| ToxValDB ToxRefDB | LEL | =1300 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15708992_15708993:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_420cfca4295614073b24b8da700a1153 |
| ToxValDB ToxRefDB | LEL | =1375 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-absolute|systemic: organ weight-uterus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685341_15685342:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cdd546e4ceb1b949b3a9cee0527961b9 |
| ToxValDB ToxRefDB | NEL | =0.015 | mg/kg bw/day | Mouse | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5333; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708987_15708988:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c892ec093a4a95bd4a43b0d082c6493b |
| ToxValDB ToxRefDB | NEL | =0.092 | mg/kg bw/day | Rat | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5332; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708983_15708984:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7708713f2d30d27a7d185e3f5a69ad40 |
| ToxValDB ToxRefDB | NEL | =40 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm morphology|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: clinical chemistry-testosterone-testosterone|systemic: organ weight-epididymis-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685337_15685338_15685339_15685340:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb1ba331d9db5115ffac029a1b668a93 |
| ToxValDB ToxRefDB | NEL | =46 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-prostate-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-seminal vesicle-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology gross-sperm measure-sperm morphology; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685343_15685344_15685345_15685346:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cd74dd1b0b10c62bdb28c283eef329d |
| ToxValDB ToxRefDB | NEL | =56 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-uterus-relative to body weight|systemic: organ weight-uterus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685347_15685348:F:F2adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_794adfe2b6666ea4d1dbefc60fcb1920 |
| ToxValDB ToxRefDB | NEL | =255 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685333_15685334_15685335_15685336:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e084e1d51a0e60e751005d5be82221f0 |
| ToxValDB ToxRefDB | NEL | =267 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-uterus-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-absolute|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685341_15685342:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17634709fd4f296cf16a3e1a087ebb4f |
| ToxValDB ToxRefDB | NEL | =650 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15708992_15708993:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_745401f9f15eb4a6298ab10a31ea4bb8 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | UF064M00AF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UF064M00AF"} |
| openFDA substances | FDA UNII substance identifier | UF064M00AF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UF064M00AF"} |
| openFDA substances | FDA UNII substance identifier | UF064M00AF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UF064M00AF"} |
| openFDA substances | FDA UNII substance identifier | UF064M00AF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UF064M00AF"} |