NOAEL Studies
Cosmetic Ingredient
DIETHYL PHTHALATE NOAEL Studies
CAS: 84-66-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =1753 | mg/kg/day | Rat (F-344; M) | oral | short-term; 3 weeks | short-term | ATSDR MRLs; row_hash=346b7bad77ab5ac0; source_hash=ToxValhc_3cb2362f30ca74d4bc22092fdecc5585; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=1753; raw_unit=mg/kg/day; method=diet; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Moody DE, Reddy JK. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol 45(2):497-504.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83 |
| Regulatory source | LOAEL | =2000 | mg/kg/day | Rat (Wistar; M) | oral | short-term; 2 days | short-term | ATSDR MRLs; row_hash=1a6d32284b69cf87; source_hash=ToxValhc_2cf6bb503752389045528565c1b0f3a4; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=2000; raw_unit=mg/kg/day; method=gavage; effect=reproductive; effect_category=reproduction; file=toxval_ATSDR_MRLs.xlsx; long_ref=Jones HB, Garside DA, Liu R, et al. 1993. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Experimental and Molecular Pathology 58:179-193.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83 |
| Regulatory source | NOAEL | =750 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=2618951401a7ab06; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 7.50e2 mg/kg-day; system=Other; basis=Decreased growth rate, food consumption and altered organ weights; point_of_departure=NOAEL : 7.50e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID7021780; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0226_summary.pdf |
| Regulatory source | RfD | =0.8 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=fc5da510cca77db7; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=8e-1; system=Other; basis=Decreased growth rate, food consumption and altered organ weights; point_of_departure=NOAEL : 7.50e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID7021780; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0226_summary.pdf |
| Regulatory source | - | =0.25 | % | rat | oral | - | - | p.18 |
| Regulatory source | - | 0.25 | % | - | - | - | - | p.18 |
| Regulatory source | - | >2.5 | % | - | - | - | - | p.18 |
| Regulatory source | - | =5 | % | rat | oral | - | - | p.18 |
| Regulatory source | - | 5 | % | - | - | - | - | p.18 |
| Regulatory source | - | 150 | mg /kg bw | rat | oral | 16 week | - | p.28 |
| Regulatory source | - | <500 | mg/kg | - | - | - | - | p.17 |
| Regulatory source | - | 1600 | mg/kg | - | - | - | - | p.17 |
| Regulatory source | carcinogenicity | 350 | mg/kg | rat | - | chronic | carcinogenicity | p.23 |
| Regulatory source | carcinogenicity | 514 | mg/kg | mouse | - | chronic | carcinogenicity | p.25 |
| Regulatory source | carcinogenicity | 1000 | mg/kg | rat | - | chronic | carcinogenicity | p.23 |
| Regulatory source | carcinogenicity | 1057 | mg/kg | mouse | - | chronic | carcinogenicity | p.25 |
| Regulatory source | carcinogenicity | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | p.27 |
| Regulatory source | carcinogenicity | 2500 | mg/kg | rat | oral | chronic | carcinogenicity | p.27 |
| Regulatory source | dermal absorption | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | p.28 |
| Regulatory source | developmental toxicity | <500 | mg/kg | - | - | - | developmental toxicity | p.17 |
| Regulatory source | developmental toxicity | =1600 | mg/kg | - | - | - | developmental toxicity | p.17 |
| Regulatory source | repeated dose toxicity | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | p.10 |
| Regulatory source | reproductive toxicity | >2.5 | % | - | - | - | reproductive toxicity | p.18 |
WHO/JECFA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =3640 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=2a6f05afb0c6723b; raw_unit=mg/kg body weight per day; context=The LOAEL in this study is estimated to be 3640 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=1410f45afe019d4f; raw_unit=mg/kg body weight per day; context=Therefore, the dose of 1.0% (750 mg/kg body weight per day) is considered to be the NOAEL. |
| WHO/JECFA | NOAEL | =1600 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=53be2a9ea00d928c; raw_unit=mg/kg body weight per day; context=A tolerable intake of 5 mg/kg body weight was estimated from a NOAEL of 1600 mg/kg body weight per day for developmental effects to which an uncertainty factor of 300 was applied. |
| WHO/JECFA | NOAEL | =1900 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=de04bbd5bbe6496d; raw_unit=mg/kg body weight per day; context=The dose of 1900 mg/kg body weight per day (2.5% in the diet) was identified as the NOAEL both for the mother and for the offspring. |
| WHO/JECFA | NOAEL | =1900 | mg/kg bw | Rat | - | - | Toxicology study | document_id=cicads_cicads_cicad52; title=Diethyl Phthalate (Cicads 52, 2003); path=mirror/documents/cicads/cicads/cicad52.htm; row_hash=5f04b90c3d4c6fa2; raw_unit=mg/kg; context=La dose sans effet nocif observable (NOAEL) était respectivement égale à 1600 et à 1900 mg/kg de poids corporel par jour pour la souris et le rat. |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >4.64 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3901; Record_ID=acute_inhalation_3586; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.64; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =8600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_10834; row=11708; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >9200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10835; row=11706; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <9500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10836; row=11707; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl phthalate; preferred_name=Diethyl phthalate; dtxsid=DTXSID7021780; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021780; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 42.5 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2763; Record_ID=adme_parameters_689; Data_Type=Measured; DTXSID=DTXSID7021780; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=42.5; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE adme parameters | Fu | 0.19 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2764; Record_ID=adme_parameters_689; Data_Type=Measured; DTXSID=DTXSID7021780; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.19; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 37 | mg/animal/day | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=8001; Record_ID=cancer_4471; Data_Type=In Vivo; Formulation_Name=Diethyl Phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=37; Response_Unit=mg/animal/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Reference=TR-429; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr429/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE cancer | Top dose | 369 | mg/animal/day | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7999; Record_ID=cancer_4472; Data_Type=In Vivo; Formulation_Name=Diethyl Phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=369; Response_Unit=mg/animal/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Dermal; Reference=TR-429; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr429/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7934; RecordID=ARPathway2016_1639; DatasetName=ARPathway2016; DTXSID=DTXSID7021780; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE skin irritation 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability | 55.4 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4702; Record_ID=skin_irritation_invitro_1287; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=55.4; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 72.4 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4699; Record_ID=skin_irritation_invitro_1292; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=72.40; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 72.7 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4698; Record_ID=skin_irritation_invitro_1294; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=72.7; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 73.8 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4697; Record_ID=skin_irritation_invitro_1310; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=73.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 75.04 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4696; Record_ID=skin_irritation_invitro_1311; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=75.04; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 86.6 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4680; Record_ID=skin_irritation_invitro_1268; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=86.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 87.8 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4679; Record_ID=skin_irritation_invitro_1271; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=87.8; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 88 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4678; Record_ID=skin_irritation_invitro_1273; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=88; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 92.54 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4677; Record_ID=skin_irritation_invitro_1275; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=92.54; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 95.31 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4676; Record_ID=skin_irritation_invitro_1277; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiSkin Irritation; Endpoint=Viability; Response=95.31; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 98 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4675; Record_ID=skin_irritation_invitro_1279; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 98.9 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4673; Record_ID=skin_irritation_invitro_1281; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=98.9; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 99.22 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4672; Record_ID=skin_irritation_invitro_1283; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=99.22; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 102.15 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4703; Record_ID=skin_irritation_invitro_1285; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=EpiDerm Irritation; Endpoint=Viability; Response=102.15; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 103.1 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4701; Record_ID=skin_irritation_invitro_1289; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.1; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin irritation | Viability | 104.3 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=4700; Record_ID=skin_irritation_invitro_1291; Data_Type=In Vitro; Formulation_Name=diethyl phthalate; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=104.3; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
NTP ICE skin sensitization 48 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 296.57 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2521; Record_ID=skin_sensitization_invitro_605; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=296.57; Reported_Response_Unit=ug/mL; Response=296.57; Response_Unit=ug/mL; Reference=Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Ashikaga and Sakaguchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD54, EC200 | 296.6 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2269; Record_ID=skin_sensitization_invitro_549; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=296.60000000000002; Reported_Response_Unit=ug/mL; Response=296.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD86, EC150 | 121.04 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8692; Record_ID=skin_sensitization_invitro_2407; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=121.04; Reported_Response_Unit=ug/mL; Response=121.04; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CD86, EC150 | >1555.68 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8147; Record_ID=skin_sensitization_invitro_2170; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=222.24; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1555.68; Converted_Response_Unit=ug/mL; Response=1555.68; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8696; Record_ID=skin_sensitization_invitro_2407; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | CV75 | 600 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2271; Record_ID=skin_sensitization_invitro_549; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=h-CLAT; Endpoint=CV75; Reported_Response=600; Reported_Response_Unit=ug/mL; Response=600; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Cys | 0.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=462; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.2; Reported_Response_Unit=%; Response=0.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Cys | 0.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=455; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys | -0.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=454; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.7; Reported_Response_Unit=%; Response=-0.7; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys | 2.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=460; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=457; Record_ID=skin_sensitization_invitro_138; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 1.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=389; Record_ID=skin_sensitization_invitro_121; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.4; Reported_Response_Unit=%; Response=1.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 59.97 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6723; Record_ID=skin_sensitization_invitro_1596; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=59.97; Reported_Response_Unit=uM; Response=59.97; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 183.54 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6720; Record_ID=skin_sensitization_invitro_1586; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=183.54; Reported_Response_Unit=uM; Response=183.54; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | <516.41 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7946; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=516.41; Reported_Response_Unit=uM; Response=516.41; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 582.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6722; Record_ID=skin_sensitization_invitro_1588; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=582.70000000000005; Reported_Response_Unit=uM; Response=582.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 913.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6724; Record_ID=skin_sensitization_invitro_1585; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=913.7; Reported_Response_Unit=uM; Response=913.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | 1180.53 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6719; Record_ID=skin_sensitization_invitro_1587; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1180.53; Reported_Response_Unit=uM; Response=1180.53; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6721; Record_ID=skin_sensitization_invitro_1589; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | IC50 | >1285 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7627; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1285; Reported_Response_Unit=uM; Response=1285; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | IC50 | 1879.05 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6747; Record_ID=skin_sensitization_invitro_1604; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1879.05; Reported_Response_Unit=uM; Response=1879.05; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.047 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6791; Record_ID=skin_sensitization_invitro_1600; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0469999999999999; Reported_Response_Unit=Unitless; Response=1.047; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.049 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6794; Record_ID=skin_sensitization_invitro_1603; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0489999999999999; Reported_Response_Unit=Unitless; Response=1.049; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.07 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6796; Record_ID=skin_sensitization_invitro_1589; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.07; Reported_Response_Unit=Unitless; Response=1.07; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.081 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6798; Record_ID=skin_sensitization_invitro_1604; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.081; Reported_Response_Unit=Unitless; Response=1.081; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.088 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6801; Record_ID=skin_sensitization_invitro_1601; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0880000000000001; Reported_Response_Unit=Unitless; Response=1.088; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6803; Record_ID=skin_sensitization_invitro_1590; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.113 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6804; Record_ID=skin_sensitization_invitro_1591; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.113; Reported_Response_Unit=Unitless; Response=1.113; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.132 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6806; Record_ID=skin_sensitization_invitro_1595; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1319999999999999; Reported_Response_Unit=Unitless; Response=1.132; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.138 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6808; Record_ID=skin_sensitization_invitro_1594; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1379999999999999; Reported_Response_Unit=Unitless; Response=1.138; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.192 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6810; Record_ID=skin_sensitization_invitro_1593; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1919999999999999; Reported_Response_Unit=Unitless; Response=1.192; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6812; Record_ID=skin_sensitization_invitro_1605; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.327 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6816; Record_ID=skin_sensitization_invitro_1592; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.327; Reported_Response_Unit=Unitless; Response=1.327; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.391 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6818; Record_ID=skin_sensitization_invitro_1598; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.391; Reported_Response_Unit=Unitless; Response=1.391; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.4 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6820; Record_ID=skin_sensitization_invitro_1607; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.427 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6821; Record_ID=skin_sensitization_invitro_1602; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.427; Reported_Response_Unit=Unitless; Response=1.427; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.534 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6823; Record_ID=skin_sensitization_invitro_1585; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.534; Reported_Response_Unit=Unitless; Response=1.534; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.656 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6825; Record_ID=skin_sensitization_invitro_1587; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.6559999999999999; Reported_Response_Unit=Unitless; Response=1.656; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.7 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6826; Record_ID=skin_sensitization_invitro_1608; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7; Reported_Response_Unit=Unitless; Response=1.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.808 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6827; Record_ID=skin_sensitization_invitro_1597; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.8080000000000001; Reported_Response_Unit=Unitless; Response=1.808; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.9 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6828; Record_ID=skin_sensitization_invitro_1588; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9; Reported_Response_Unit=Unitless; Response=1.9; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 1.999 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6829; Record_ID=skin_sensitization_invitro_1599; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9990000000000001; Reported_Response_Unit=Unitless; Response=1.999; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 2.047 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6830; Record_ID=skin_sensitization_invitro_1596; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.0470000000000002; Reported_Response_Unit=Unitless; Response=2.047; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 2.522 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6832; Record_ID=skin_sensitization_invitro_1586; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.5219999999999998; Reported_Response_Unit=Unitless; Response=2.522; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Imax | 3.369 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7523; Record_ID=skin_sensitization_invitro_1795; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=LuSens; Endpoint=Imax; Reported_Response=3.369076721; Reported_Response_Unit=Unitless; Response=3.369; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10722; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Induction dose per skin area | 6207 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10720; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10726; Record_ID=skin_sensitization_invivo_2351; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021780; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Ryan et al. 2000; 10945748; 10.1034/j.1600-0536.2000.043002095.x|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021780; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021780 |
SCCNFP Opinion 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =0.2 | % | rat | oral | Sub-chronic | repeated dose toxicity | Ref.: 3, 10 2, p.10 |
| SCCNFP Opinion | NOAEL | =0.25 | % | rat | oral | - | NOAEL study | Ref.: 24, 69, 75, 109 2, p.18 |
| SCCNFP Opinion | NOAEL | >2.5 | % | - | - | - | reproductive toxicity | p.18 |
| SCCNFP Opinion | NOAEL | =5 | % | rat | oral | - | NOAEL study | Ref.: 24, 69, 75, 109 2, p.18 |
| SCCNFP Opinion | NOAEL | =150 | mg /kg bw | rat | oral | 16 week | dermal absorption | (Ref.115), p.28 |
| SCCNFP Opinion | NOAEL | =350 | mg/kg | rat | - | chronic | carcinogenicity | p.23 |
| SCCNFP Opinion | NOAEL | <500 | mg/kg | - | - | - | developmental toxicity | p.17 |
| SCCNFP Opinion | NOAEL | =514 | mg/kg | mouse | - | chronic | carcinogenicity | p.25 |
| SCCNFP Opinion | NOAEL | =1000 | mg/kg | rat | - | chronic | carcinogenicity | p.23 |
| SCCNFP Opinion | NOAEL | =1057 | mg/kg | mouse | - | chronic | carcinogenicity | p.25 |
| SCCNFP Opinion | NOAEL | =1250 | mg/kg | rat | oral | chronic | carcinogenicity | Ref.: 59, 70, 77 2, p.27 |
| SCCNFP Opinion | NOAEL | =1600 | mg/kg | - | - | - | developmental toxicity | p.17 |
| SCCNFP Opinion | NOAEL | =2500 | mg/kg | rat | oral | chronic | carcinogenicity | Ref.: 59, 70, 77 2, p.27 |
EPA ToxRefDB v3 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =0.031 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 4 week | SAC | study_id=5333; toxval_study_source_id=studyid5333_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.123 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5334; toxval_study_source_id=studyid5334_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|in life observation-clinical signs-scabbing|in life observation-mortality-mortality; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.184 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 4 week | SAC | study_id=5332; toxval_study_source_id=studyid5332_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight; dose_level=3; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =197 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-testosterone-testosterone|pathology gross-sperm measure-sperm morphology|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|organ weight-adrenal gland-absolute|organ weight-epididymis-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =222 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm morphology|organ weight-adrenal gland-relative to body weight|organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-seminal vesicle-relative to body weight|organ weight-prostate-absolute; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =325 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|organ weight-kidney-relative to body weight|in life observation-clinical signs-desquamation; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1150 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Juvenile_F1_M_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-pituitary gland-relative to body weight|organ weight-spleen-absolute|organ weight-adrenal gland-absolute|organ weight-thymus-absolute|organ weight-brain-relative to body weight|organ weight-thymus-relative to body weight|organ weight-liver-relative to body weight|in life observation-body weight-offspring (pup) weight; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1297 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1300 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|in life observation-clinical signs-desquamation; dose_level=3; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1375 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-uterus-absolute|organ weight-kidney-relative to body weight; dose_level=3; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5334; toxval_study_source_id=studyid5334_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|pathology microscopic-skin-acanthosis|in life observation-clinical signs-scabbing; dose_level=0; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.015 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 4 week | SAC | study_id=5333; toxval_study_source_id=studyid5333_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=1; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.092 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 4 week | SAC | study_id=5332; toxval_study_source_id=studyid5332_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =40 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm morphology|organ weight-adrenal gland-absolute|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|clinical chemistry-testosterone-testosterone|organ weight-epididymis-absolute|organ weight-liver-relative to body weight; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =46 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_M_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-seminal vesicle-relative to body weight|organ weight-prostate-absolute|organ weight-adrenal gland-relative to body weight|pathology gross-sperm measure-sperm morphology; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =56 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F2_F_systemic; toxval_effect_list=organ weight-uterus-absolute|organ weight-uterus-relative to body weight; dose_level=1; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =255 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =267 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=1183; toxval_study_source_id=studyid1183_Adult_F1_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-uterus-absolute|organ weight-liver-absolute|organ weight-kidney-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2005; study_citation=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; dsstox_substance_id=DTXSID7021780; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =650 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5335; toxval_study_source_id=studyid5335_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-adenoma/carcinoma combined|in life observation-clinical signs-desquamation; dose_level=2; study_year=1995; study_citation=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; dsstox_substance_id=DTXSID7021780; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ATSDR MRLs 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =1753 | mg/kg bw/day | Rat | oral | short-term; 3 weeks | short-term | LONG_REF=Moody DE, Reddy JK. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol 45(2):497-504.; TITLE=Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds; AUTHOR=Moody DE; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp73.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447548:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3cb2362f30ca74d4bc22092fdecc5585 |
| ToxValDB ATSDR MRLs | LOAEL | =2000 | mg/kg bw/day | Rat | oral | short-term; 2 days | short-term | LONG_REF=Jones HB, Garside DA, Liu R, et al. 1993. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Experimental and Molecular Pathology 58:179-193.; TITLE=The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo; AUTHOR=Jones HB; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp73.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447547:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2cf6bb503752389045528565c1b0f3a4 |
| ToxValDB ATSDR MRLs | MRL | =6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=hepatic in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca0f8d71ff9dbf9a05469bd3be84ff77 |
| ToxValDB ATSDR MRLs | MRL | =7 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=reproductive in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447025_15447026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ea317f15593346f7189556222bb9958 |
ToxValDB Alaska DEC 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.72 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446182:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=266307f694c555e1087800e283b3fb78 |
| ToxValDB Alaska DEC | RfD | =0.8 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446183:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=433a0901915c1f6fc7281df5c0496b5a |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =63627.3 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2023; ORIGINAL_YEAR=2023; STUDY_GROUP=DOE Protective Action Criteria:15514486:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66c68563ee268fda22d2a0ffd06e54de |
ToxValDB DOE Wildlife Benchmarks 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =4583 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511611:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a93b5781c1b09e2969bd6f2b15a20ae0 |
ECHA 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | >=1015 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217981; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818672:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac099091c8761cf19ca63d22d0e9966b |
| ECHA | LEL | >=1050 | mg/kg bw/day | Rat | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217981; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818671:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c176839abde943c11cc1e26254b65f34 |
| ECHA | LEL | >=1100 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d21798b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/8?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15818988:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_002574d3ca867dea833e2f180058dca4 |
| ECHA | LOAEL | =3640 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15859459_15859597:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34d69445e18090a95dea47642c5598cf |
| ECHA | NOAEL | =11.7 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc9d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/6/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15832201:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_adc75cec0ea9b0319a80275a06b8b8ad |
| ECHA | NOAEL | <500 | mg/kg bw/day | Mouse | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/3?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15822641:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58a23a9f1bec96308125a1ea6354ee35 |
| ECHA | NOAEL | =1600 | mg/kg bw/day | Mouse | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/3?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15821325:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44476bc55183232545c255b99a4c6deb |
| ECHA | NOAEL | =3000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21c9e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855397_15856218:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07ad52288a40da1cb71c4ab116c54af4 |
| ECHA | NOAEL | >4400 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba33f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15857663:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a360faa229c6fa3dea1efd4821ec240 |
| ECHA | NOAEL | =15000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21c9e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16604/7/9/2?documentUUID=f024a33e-4a3a-4604-a803-d831e4089123; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855397_15856218:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59959156aec030c4381e9e312b92b381 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.53(1): 35-41 Oishi,S., and K. Hiraga Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations 1980; TITLE=Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations; AUTHOR=Oishi,S., and K. Hiraga; DOI=10.1016/0041-008x(80)90378-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=66065; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content|Growth: Weight|Hormone(s): Dihydrotestosterone|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597152_15598243:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d2892a6d32328e03e4f9c8bfb56cbd9 |
| ToxValDB ECOTOX | NOEL | =4500 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Mortality: Survival|Growth: Weight|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15612052:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=59994231015f1cd7be6aadea377cf802 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =10.56 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631201:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee625aa23d3ae613fed55999e868b512 |
ToxValDB HPVIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.D. Brown, K. R. Butterworth, I. F. Gaunt, P. Grassom, and S. D. Gangolli. (1978). Short-term oral toxicity study of diethyl phthalate in the rat. Food and Cosmetic Toxicology, 16: 415-422.; QUALITY=1; EXTERNAL_SOURCE_ID=63163; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639370:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1982d77cad7f571ca8ebb85c05f80682 |
| ToxValDB HPVIS | NOAEL | =750 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.D. Brown, K. R. Butterworth, I. F. Gaunt, P. Grassom, and S. D. Gangolli. (1978). Short-term oral toxicity study of diethyl phthalate in the rat. Food and Cosmetic Toxicology, 16: 415-422.; QUALITY=1; EXTERNAL_SOURCE_ID=61317; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639167:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b3c25b58aa92997423801177f5a62c8d |
| ToxValDB HPVIS | NOAEL | =3210 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Field, et al. (1993). Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology, 38:33-44.; QUALITY=1; EXTERNAL_SOURCE_ID=58231; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642390:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd2db2b08a089b3e3fa7a51c7a6903e2 |
| ToxValDB HPVIS | NOAEL | =3250 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.J.C. Lamb, IV, R.E. Chapin, C.J. Teague, A.D. Lawton and J.R. Reel (1987). Reproductive effects of four phthalate acid esters in the mouse. Toxicology and Applied Pharmacology88:255-269.; QUALITY=2; EXTERNAL_SOURCE_ID=65159; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15643130:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fc3937fe7ef5ee2b855b2d61d45e41af |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =3160 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | LONG_REF=Brown, D., K.R. Butterworth, I.F. Gaunt, P. Grasso and S.D. Gangolli. 1978. Short-term oral toxicity study of diethyl phthalate in the rat. Food Cosmet. Toxicol. 16: 415-422.; TITLE=Short-term oral toxicity study of diethyl phthalate in the rat; AUTHOR=Brown, D., K.R. Butterworth, I.F. Gaunt, P. Grasso and S.D. Gangolli; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=226; TOXICOLOGICAL_EFFECT=reduced growth rate, food consumption and altered organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645071_15645073:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4a698363e6b3ececf5f50021ba34f458 |
ToxValDB ToxRefDB 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =0.031 | mg/kg bw/day | Mouse | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5333; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708987_15708988:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4bfa7caa6b3e2d6f6763249e33781187 |
| ToxValDB ToxRefDB | LEL | =0.123 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5334; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-scabbing|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB:15708989:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79335b92a5449b5a7386827f41f5b2b8 |
| ToxValDB ToxRefDB | LEL | =0.184 | mg/kg bw/day | Rat | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5332; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708983_15708984:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b095e4eb99fe9fab68c9b22f73983f09 |
| ToxValDB ToxRefDB | LEL | =197 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-testosterone-testosterone|systemic: pathology gross-sperm measure-sperm morphology|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: organ weight-liver-relative to body weight|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-epididymis-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685337_15685338_15685339_15685340:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f654a6ffad1ba5a954852e5419319a40 |
| ToxValDB ToxRefDB | LEL | =222 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm morphology|systemic: organ weight-prostate-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-seminal vesicle-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685343_15685344_15685345_15685346:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e6d7dc980fed419c4cea357775eaa41 |
| ToxValDB ToxRefDB | LEL | =325 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|organ weight; STUDY_GROUP=ToxRefDB:15708991:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1ea00ebcf33b54e7a429f9e72f2506e |
| ToxValDB ToxRefDB | LEL | =1150 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-thymus-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-pituitary gland-relative to body weight|systemic: organ weight-brain-relative to body weight|systemic: organ weight-spleen-absolute|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-body weight-offspring (pup) weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685353_15685354_15685355_15685356:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0df7b784dd9ce9c9668629e76755373 |
| ToxValDB ToxRefDB | LEL | =1297 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685333_15685334_15685335_15685336:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66ac4532bfc80d4b990f4903c864c245 |
| ToxValDB ToxRefDB | LEL | =1300 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15708992_15708993:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_420cfca4295614073b24b8da700a1153 |
| ToxValDB ToxRefDB | LEL | =1375 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-absolute|systemic: organ weight-uterus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685341_15685342:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cdd546e4ceb1b949b3a9cee0527961b9 |
| ToxValDB ToxRefDB | NEL | =0.015 | mg/kg bw/day | Mouse | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5333; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708987_15708988:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c892ec093a4a95bd4a43b0d082c6493b |
| ToxValDB ToxRefDB | NEL | =0.092 | mg/kg bw/day | Rat | dermal | short-term; 4 weeks | short-term | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_4-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5332; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708983_15708984:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7708713f2d30d27a7d185e3f5a69ad40 |
| ToxValDB ToxRefDB | NEL | =40 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm morphology|systemic: organ weight-adrenal gland-absolute|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: clinical chemistry-testosterone-testosterone|systemic: organ weight-epididymis-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685337_15685338_15685339_15685340:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb1ba331d9db5115ffac029a1b668a93 |
| ToxValDB ToxRefDB | NEL | =46 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-prostate-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-seminal vesicle-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology gross-sperm measure-sperm morphology; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15685343_15685344_15685345_15685346:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cd74dd1b0b10c62bdb28c283eef329d |
| ToxValDB ToxRefDB | NEL | =56 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-uterus-relative to body weight|systemic: organ weight-uterus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685347_15685348:F:F2adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_794adfe2b6666ea4d1dbefc60fcb1920 |
| ToxValDB ToxRefDB | NEL | =255 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685333_15685334_15685335_15685336:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e084e1d51a0e60e751005d5be82221f0 |
| ToxValDB ToxRefDB | NEL | =267 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Japan: Fuji. A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats. The Journal of Toxicological Sciences, Vol.30 , Special Issue, 97-116, 2005; TITLE=A Two-Generation Reproductive Toxicity Study of Diethyl Phthalate (DEP) in Rats; AUTHOR=Japan: Fuji; EXTERNAL_SOURCE_ID=1183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=systemic: organ weight-uterus-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-absolute|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15685341_15685342:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17634709fd4f296cf16a3e1a087ebb4f |
| ToxValDB ToxRefDB | NEL | =650 | mg/kg bw/day | Mouse | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1995_Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; TITLE=Toxicology and carcinogenesis studies of diethylphthalate (CAS No. 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies)_2-year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5335; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: in life observation-clinical signs-desquamation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15708992_15708993:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_745401f9f15eb4a6298ab10a31ea4bb8 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | UF064M00AF | UNII | - | - | - | chemical | - |