NOAEL Studies Cosmetic Ingredient

Diethyl Succinate NOAEL Studies

INCI: DIETHYL SUCCINATE

CAS: 123-25-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 15000 mg/kg bw/day mouse oral 10 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =8530 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2021; row=4697; data_type=In Vivo; mixture=Chemical; chemical_name=Diethyl butanedioate; preferred_name=Diethyl butanedioate; dtxsid=DTXSID2038732; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2038732; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7918; RecordID=ARPathway2016_715; DatasetName=ARPathway2016; DTXSID=DTXSID2038732; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2038732
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4557; Record_ID=skin_sensitization_invivo_1095; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2038732; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80082-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2038732
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4555; Record_ID=skin_sensitization_invivo_1095; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2038732; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80082-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2038732
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4561; Record_ID=skin_sensitization_invivo_1095; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2038732; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80082-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2038732
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ELP55C13DR UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ELP55C13DR"}
openFDA substances FDA UNII substance identifier ELP55C13DR UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ELP55C13DR"}
openFDA substances FDA UNII substance identifier ELP55C13DR UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ELP55C13DR"}
openFDA substances FDA UNII substance identifier ELP55C13DR UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H14O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ELP55C13DR"}