NOAEL Studies
Cosmetic Ingredient
Diethylamine NOAEL Studies
INCI: DIETHYLAMINE
CAS: 109-89-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=a7e65a59-19c9-457f-b29a-bc22a1ece26d_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=a7e65a59-19c9-457f-b29a-bc22a1ece26d/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d2356ec-78ed-4658-9944-42199b0cea0d |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=e9d1f203-de8e-415c-abd8-25f599ec1c59 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=52e09a67-2c1a-484d-9161-c86b47ce3d0c |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=9641f27f-8548-4a1f-a627-bd00d5fc6f78 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=5a1e6ac1-cdba-48e9-900a-506e92fd27bd |
| ECHA | NOAEL | 45 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=0e6b5e4a-0710-416f-81ce-e7bbaf3a1802 |
| ECHA | NOAEL | 135 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=87356ed1-c525-42ea-922c-a9ed32b2ebf5 |
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=a7e65a59-19c9-457f-b29a-bc22a1ece26d_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=a7e65a59-19c9-457f-b29a-bc22a1ece26d/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d2356ec-78ed-4658-9944-42199b0cea0d |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=e9d1f203-de8e-415c-abd8-25f599ec1c59 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=52e09a67-2c1a-484d-9161-c86b47ce3d0c |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=9641f27f-8548-4a1f-a627-bd00d5fc6f78 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=5a1e6ac1-cdba-48e9-900a-506e92fd27bd |
| ECHA | NOAEL | 45 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=0e6b5e4a-0710-416f-81ce-e7bbaf3a1802 |
| ECHA | NOAEL | 135 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=87356ed1-c525-42ea-922c-a9ed32b2ebf5 |
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=a7e65a59-19c9-457f-b29a-bc22a1ece26d_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=a7e65a59-19c9-457f-b29a-bc22a1ece26d/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=7d2356ec-78ed-4658-9944-42199b0cea0d |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=e9d1f203-de8e-415c-abd8-25f599ec1c59 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e1314541-8d83-4eb5-aff6-dd9569107ef5_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e1314541-8d83-4eb5-aff6-dd9569107ef5/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=52e09a67-2c1a-484d-9161-c86b47ce3d0c |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=9641f27f-8548-4a1f-a627-bd00d5fc6f78 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=e0813f89-1e24-43ab-85c5-8d970b5f7b82_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=e0813f89-1e24-43ab-85c5-8d970b5f7b82/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2009; basis=other:; key_result=false; entry_uuid=5a1e6ac1-cdba-48e9-900a-506e92fd27bd |
| ECHA | NOAEL | 45 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=0e6b5e4a-0710-416f-81ce-e7bbaf3a1802 |
| ECHA | NOAEL | 135 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6z; document=d603e66e-4436-4ec4-8058-9e83710ab990_9ad93550-6e1d-4930-a754-5522b1d6bf2e.i6d; document_key=d603e66e-4436-4ec4-8058-9e83710ab990/9ad93550-6e1d-4930-a754-5522b1d6bf2e; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-13; basis=other:; key_result=false; entry_uuid=87356ed1-c525-42ea-922c-a9ed32b2ebf5 |
| ECHA | LEL | =560 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8319/7/3/3?documentUUID=3e74785a-2de4-4344-9b72-259c1587d98b; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797315_15797366:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_986358421d682e88c3a6a2bd7ee02421 |
| ECHA | LEL | =610 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8319/7/3/3?documentUUID=3e74785a-2de4-4344-9b72-259c1587d98b; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797315_15797366:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd43512819a9a76f1dcdb9d956e995cc |
| ECHA | NOAEL | =76 | mg/m3 | Rat | inhalation | chronic; 24 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fb0e4b096bca877e6d5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8319/7/6/3?documentUUID=3e74785a-2de4-4344-9b72-259c1587d98b; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15826964:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7af4094280358853e02159616f11cac3 |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 17.0402 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3360; Record_ID=acute_inhalation_2570; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=17.0402; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13453/7/3/3/?documentUUID=1effd2eb-eaaf-4acd-b72a-48adcc4d69df; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
| NTP ICE acute inhalation | LC50 | 11.958 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3361; Record_ID=acute_inhalation_1165; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.958; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =540 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_880; row=10092; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylamine; preferred_name=Diethylamine; dtxsid=DTXSID6021909; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021909; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_881; row=10093; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylamine; preferred_name=Diethylamine; dtxsid=DTXSID6021909; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021909; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 62.5 | ppm | Mouse | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6885; Record_ID=cancer_5599; Data_Type=In Vivo; Formulation_Name=Diethylamine; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=62.5; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1/N; Sex=Female; Route=Inhalation; Reference=TR-566; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr566/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
| NTP ICE cancer | Top dose | 125 | ppm | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6893; Record_ID=cancer_5600; Data_Type=In Vivo; Formulation_Name=Diethylamine; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=125; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Inhalation; Reference=TR-566; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr566/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
NTP ICE skin irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 33 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4148; Record_ID=skin_irritation_invitro_60; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=Corrositex; Endpoint=Breakthrough Time; Response=33; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
| NTP ICE skin irritation | Breakthrough Time | 34 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4151; Record_ID=skin_irritation_invitro_58; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=Corrositex; Endpoint=Breakthrough Time; Response=34; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
| NTP ICE skin irritation | TER | 0.9 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4153; Record_ID=skin_irritation_invitro_2545; Data_Type=In Vitro; Concentration=35; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=TER Corrosion; Endpoint=TER; Response=0.9; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
NTP ICE skin sensitization 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | EC3 | 14.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13093; Record_ID=skin_sensitization_invivo_3088; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6021909; Assay=LLNA; Endpoint=EC3; Response=14.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=De Jong et al. 2002; 12062936; 10.1016/s0300-483x(02)00131-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021909; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021909 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =53844.9 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15514505:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd8ba30055ca39a7cd0280d51dc67c1a |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =75 | mg/m3 | Rat | inhalation | chronic; 24 weeks | chronic | LONG_REF=Lynch D.W., Moorman W .J., Stober P., Lewis T.R., Iverson W. O. (1986) Subchronic inhalation of diethylamine vapour in Fisher-344 rats: organ toxicity. Fundam. Appl. Toxicol 6:559-565.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d38eb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/075_diethylamine_oel_en.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=pathology; STUDY_GROUP=EU SCOEL:15952394:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4196009264b6332dea7b2d02503cbd5e |
ToxValDB GESTIS DNEL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =9.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631153_15631154_15631155:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_343fa0571707b6d99d424f18dcf9e140 |
| ToxValDB GESTIS DNEL | DNEL local | =15 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631153_15631154_15631155:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a23c9734d84cb6a17a7beb2c3e620ca |
| ToxValDB GESTIS DNEL | DNEL systemic | =0.64 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631153_15631154_15631155:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5db9bb39a2c88f445acccfe4b6907cd8 |
ToxValDB TX TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | BMCL (10) | =17.0808 | mg/m3 | Mouse | inhalation | chronic; 105 weeks | chronic | LONG_REF=National Toxicology Program (NTP). 2011. NTP Technical Report on the Toxicology and Carcinogenesis studies of Diethylamine in F344/N Rats and B6C3F1 Mice (Inhalation Studies); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b19; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/dea.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Hyperostosis in the turbinates in mouse; STUDY_GROUP=TX TCEQ:15954411:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_680e227e35a1cf887ec16a9bc6d03105 |
| ToxValDB TX TCEQ | LOAEL | =29.9139 | mg/m3 | Human | inhalation | acute; 60 minutes | clinical | LONG_REF=Lundqvist, GR, M Yamagiwa, OF Pedersen, GD Nielsen. 1992. Inhalation of diethylamine- acute nasal effects and subjective response. American Industrial Hygiene Association Journal 53(3): 181-185; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b19; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/dea.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Low to moderate nasal and eye irritation; STUDY_GROUP=TX TCEQ:15954414:M:-adult; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_145b2e303db6238f8c66582e15a0a72b |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | B035PIS86W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B035PIS86W"} |
| openFDA substances | FDA UNII substance identifier | B035PIS86W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B035PIS86W"} |
| openFDA substances | FDA UNII substance identifier | B035PIS86W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B035PIS86W"} |
| openFDA substances | FDA UNII substance identifier | B035PIS86W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B035PIS86W"} |