Good Cosmetic Ingredient NOAEL Data

Diethylaminoethyl Methacrylate

INCI: DIETHYLAMINOETHYL METHACRYLATE

CAS Number
105-16-8
Function
Monomer for hair-fixing and film-forming copolymers
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Tertiary amine; not restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diethylaminoethyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 50 mg/kg bw/day oral rat oral REACH

Expert Verdict

Methacrylate monomers are known skin sensitizers in occupational settings; residual monomer must be controlled (typically <100 ppm) with supplier certificate required in CPSR.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Diethylaminoethyl Methacrylate safe in cosmetics?

Methacrylate monomers are known skin sensitizers in occupational settings; residual monomer must be controlled (typically <100 ppm) with supplier certificate required in CPSR. The EU classifies Diethylaminoethyl Methacrylate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Diethylaminoethyl Methacrylate allowed in the EU?

Diethylaminoethyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylaminoethyl Methacrylate do in cosmetics?

Diethylaminoethyl Methacrylate functions as: Monomer for hair-fixing and film-forming copolymers. It is classified as a cosmetic ingredient in our database. CAS number: 105-16-8.

What is the Margin of Safety for Diethylaminoethyl Methacrylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diethylaminoethyl Methacrylate?

The NOAEL (No Observed Adverse Effect Level) for Diethylaminoethyl Methacrylate is 50 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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