NOAEL Studies
Cosmetic Ingredient
Diethylbenzene NOAEL Studies
INCI: DIETHYLBENZENE
CAS: 25340-17-4 (mixed isomers)
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=ea39a239-924e-413c-8c5c-4027ba63e8dc_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=ea39a239-924e-413c-8c5c-4027ba63e8dc/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; key_result=false; entry_uuid=85cf18c5-469f-4d3f-814b-ee0b7fd72824 |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=ea39a239-924e-413c-8c5c-4027ba63e8dc_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=ea39a239-924e-413c-8c5c-4027ba63e8dc/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; key_result=false; entry_uuid=7832ed88-3fb3-4708-a692-0c224426802f |
| ECHA | NOAEL | 30 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=59730bd6-7c22-49b5-83f5-3d8e00496fb6_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=59730bd6-7c22-49b5-83f5-3d8e00496fb6/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1992-12-31; basis=other:; key_result=false; entry_uuid=bf949359-2c4d-4d32-bcf0-e48045695706 |
| ECHA | NOAEL | >750 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=59730bd6-7c22-49b5-83f5-3d8e00496fb6_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=59730bd6-7c22-49b5-83f5-3d8e00496fb6/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1992-12-31; basis=other:; key_result=false; entry_uuid=3bdfdec5-5eb0-4ec8-b819-4c918019791e |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=773453bc-b055-421d-90e4-da6e965bf1e6_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=773453bc-b055-421d-90e4-da6e965bf1e6/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=ab0b5cd6-b511-4571-9747-35a7e61572aa |
| ECHA | NOAEL | 5 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=6696ca1e-2613-4b8c-b99d-f34811617f26_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=6696ca1e-2613-4b8c-b99d-f34811617f26/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1999; basis=other:; key_result=false; entry_uuid=9bf5a59a-3c82-4fc1-b146-61e6141a8fb9 |
| ECHA | NOEL | 150 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=59730bd6-7c22-49b5-83f5-3d8e00496fb6_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=59730bd6-7c22-49b5-83f5-3d8e00496fb6/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1992-12-31; basis=other:; key_result=false; entry_uuid=880ba0be-d40d-493a-bd45-90801ba88be1 |
| ECHA | NOEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=29c06960-a42b-495c-88f4-5a764535d974_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=29c06960-a42b-495c-88f4-5a764535d974/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=true; entry_uuid=d7986b6f-7d13-4aad-8cf4-e2b3b92bc5d8 |
| ECHA | NOEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=29c06960-a42b-495c-88f4-5a764535d974_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=29c06960-a42b-495c-88f4-5a764535d974/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=true; entry_uuid=e7b53365-b31f-4a6f-8910-c32596f0482b |
| ECHA | NOEL | >200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=4f9cf382-c5b2-415a-8613-fd11df22d338.i6z; document=29c06960-a42b-495c-88f4-5a764535d974_4f9cf382-c5b2-415a-8613-fd11df22d338.i6d; document_key=29c06960-a42b-495c-88f4-5a764535d974/4f9cf382-c5b2-415a-8613-fd11df22d338; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=other:; key_result=true; entry_uuid=9d304f32-edfd-4e6b-aeda-518de6a08f0c |
| ECHA | LOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 10 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2100/7/6/2?documentUUID=4f9cf382-c5b2-415a-8613-fd11df22d338; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845218_15845219_15848930:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_126ecfb977fb90a5b60e12cf531d7be7 |
| ECHA | LOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 10 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2100/7/6/2?documentUUID=4f9cf382-c5b2-415a-8613-fd11df22d338; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845218_15845219_15848930:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_efe7159d18f886e6a9d3868b6a6aaeae |
| ECHA | NOAEL | =190 | mg/m3 | Rat | inhalation | chronic; 64 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2100/7/6/3?documentUUID=4f9cf382-c5b2-415a-8613-fd11df22d338; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827731_15829076:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1150b86fb1675517cadd817b582ede6 |
| ECHA | NOEL | =20 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2100/7/9/3?documentUUID=4f9cf382-c5b2-415a-8613-fd11df22d338; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824640_15824641:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ee95eec279ab4be500d04d80d998370 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =21.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631170:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_63c081ec9ce054850ce34cda33b41dc0 |
ToxValDB HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =190 | mg/m3 | Rat | inhalation | subchronic; 8 weeks | reproduction developmental | LONG_REF=Kaempfe, T. A. and Thake, D. C. 1993. Three-Month Inhalation Study of MCS 2313 [Mixed Diethylbenzenes] in Sprague-Dawley Rats. Monsanto Environmental Health Laboratory Report No. MSL-12570.Other Available Reports: Gagnaire, F., Marignac, B., and de Ceaurriz, J. (1990) Diethylbenzene-induced sensorimotor neuropathy in rats. J. Applied Toxicology 10(2): 105-112. 3D: Not reliable. Relevant methodological deficiencies.Gagniare, F., Ensminger A., Marignac, B., and De Ceaurriz (1991) Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats. J. Appl. Toxicology 11(4) 261-268. 3D: Not reliable. Relevant methodological deficiencies.Gagnaire, F., Becker, M. N., Marignac, B., Bonnet, P., and DeCeaurriz, J. (1992) Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potential in rats. J. Applied Toxicology 12(5): 335-342. 3D: Not reliable. Relevant methodological deficiencies.Gagnaire, F., Becker, M. N., and De Ceaurriz, J. (1992) Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats. J. Applied Toxicology 12(5): 343-350. 3D: Not reliable. Relevant methodological deficiencies.MHW, Japan (1993) Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test of 1,4-Diethylbenzene. Unpublished Report for OECD-SIDS program.4A: Not assignable; only short abstract available.; QUALITY=1; EXTERNAL_SOURCE_ID=62865; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS:15639350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b04c14dcd8b73eb290cee4e0d007b29d |