NOAEL Studies Cosmetic Ingredient

Diethylene Glycol NOAEL Studies

INCI: DIETHYLENE GLYCOL

CAS: 111-46-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 225 day Chronic SCCS; Gaunt, IF, et al. (1976) In BIBRA Inf Bull 15: 217-218
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 225 day Chronic SCCS; Gaunt, IF, et al. (1976) In BIBRA Inf Bull 15: 217-218
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA ADI (group) =0.5 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2967 - Consumers - Safety of the proposed amendment of the specifications for the food additive polyvinyl alcohol-polyethylene glycol-graft-co-polymer (E 1209) - doi:10.2903/j.efsa.2017.4865
NTP ICE acute oral 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =12565 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1037; row=13197; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =12570 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1038; row=13198; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =15600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1039; row=13190; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =15650 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1040; row=13191; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =16547 mg/kg bw Rat (Male/Female) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1041; row=13196; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =16600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1042; row=13192; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =20760 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1043; row=13193; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =28733 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1044; row=13194; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =30186 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1045; row=13195; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol; preferred_name=Diethylene glycol; dtxsid=DTXSID8020462; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020462; source_file=acute_oral.xlsx
NTP ICE adme parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Fu 0.97 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3090; Record_ID=adme_parameters_2032; Data_Type=Measured; DTXSID=DTXSID8020462; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.97; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, ECVAM; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
NTP ICE dart 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE dart LOEL 2795 mg/kg bw/day Mouse Oral - In Vivo; DART, In life observation sheet=Data; excel_row=116580; Record_ID=dart_24417; Data_Type=In Vivo; DTXSID=DTXSID8020462; Assay=DART, In life observation; Endpoint=LOEL; Response=2795; Response_Unit=mg/kg/day; Species=Mouse; Strain=Crl:CD-1(ICR)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0013123;CUI;Water consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0013123;CUI;Water consumption; Reference=ToxRefDB v2 , ID = 5351; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
NTP ICE dart LOEL 4472 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=116577; Record_ID=dart_24214; Data_Type=In Vivo; DTXSID=DTXSID8020462; Assay=DART, In life observation; Endpoint=LOEL; Response=4472; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0013123;CUI;Water consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0013123;CUI;Water consumption; Reference=ToxRefDB v2 , ID = 5350; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
NTP ICE dart LOEL 4472 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=116578; Record_ID=dart_24303; Data_Type=In Vivo; DTXSID=DTXSID8020462; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=4472; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0443239;CUI;Interrupted; Reference=ToxRefDB v2 , ID = 5350; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
NTP ICE dart LOEL 11180 mg/kg bw/day Mouse Oral - In Vivo; DART, In life observation sheet=Data; excel_row=116581; Record_ID=dart_24438; Data_Type=In Vivo; DTXSID=DTXSID8020462; Assay=DART, In life observation; Endpoint=LOEL; Response=11180; Response_Unit=mg/kg/day; Species=Mouse; Strain=Crl:CD-1(ICR)BR; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 5351; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7952; RecordID=ARPathway2016_569; DatasetName=ARPathway2016; DTXSID=DTXSID8020462; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020462; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020462
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1.6 mg/kg bw/day - dermal chronic NOAEL study p.23
SCCS Opinion NOAEL =10 - rat - - NOAEL study p.10
SCCS Opinion NOAEL =50 mg/kg bw/day rat oral 225 days NOAEL study p.9
SCCS Opinion NOAEL =200 mg/kg/day rat - - NOAEL study (ref. 6), p.10
SCCS Opinion NOAEL =200 mg/kg bw/day rat - - genotoxicity (Ref. 7), p.10
SCCS Opinion NOAEL =559 mg/kg bw/day rat oral developmental developmental toxicity p.13
SCCS Opinion NOAEL =612 mg/kg bw/day rat oral - reproductive toxicity p.22
SCCS Opinion NOAEL =1118 mg/kg bw/day rat oral developmental developmental toxicity p.14
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =69445.6 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15514524:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_854a26cf64f3886f0918c1cfb5ac00c1
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =60 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630214_15630215:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2cb090e84c5231c26e2e018bff09be6
ToxValDB GESTIS DNEL DNEL systemic =44 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630214_15630215:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d32b5488ac4a69981bd0e7758385a63
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1.6 mg/kg bw/day - dermal chronic - p.23
Regulatory source - 10 - rat - - - p.10
Regulatory source - 50 mg/kg bw/day rat oral 225 days - p.9
Regulatory source - 200 mg/kg/day rat - - - p.10
Regulatory source developmental toxicity 559 mg/kg bw/day rat oral developmental developmental toxicity p.13
Regulatory source developmental toxicity 1118 mg/kg bw/day rat oral developmental developmental toxicity p.14
Regulatory source genotoxicity 50 mg/kg bw/day rat - - genotoxicity p.10
Regulatory source genotoxicity 200 mg/kg bw/day rat - - genotoxicity p.10
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat - - repeated dose toxicity p.19
Regulatory source reproductive toxicity 50 mg/kg bw/day rat oral - reproductive toxicity p.22
Regulatory source reproductive toxicity 612 mg/kg bw/day rat oral - reproductive toxicity p.22
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 61BR964293 UNII - - - chemical -