NOAEL Studies
Cosmetic Ingredient
Diethylhexyl Adipate NOAEL Studies
INCI: DIETHYLHEXYL ADIPATE
CAS: 103-23-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =170 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=07ac87d567383949; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.70e2 mg/kg-day; system=Developmental, Hepatic, Urinary, Musculoskeletal, Other; basis=Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size; point_of_departure=NOAEL : 1.70e2 mg/kg-day; composite_uf=300; confidence=Medium; dtxsid=DTXSID0020606; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=420; rfd_last_updated=07/01/1992; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0420_summary.pdf |
| Regulatory source | RfD | =0.6 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=c301dcfa53c404c2; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=6e-1; system=Developmental, Hepatic, Urinary, Musculoskeletal, Other; basis=Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size; point_of_departure=NOAEL : 1.70e2 mg/kg-day; composite_uf=300; confidence=Medium; dtxsid=DTXSID0020606; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=420; rfd_last_updated=07/01/1992; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0420_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 2000 | IARC Monographs | - |
NTP ICE acute oral 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =5600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_296; row=427; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_298; row=422; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9110 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_300; row=423; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =19100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_301; row=424; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >20000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_302; row=425; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =25000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_304; row=426; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =45000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_306; row=421; data_type=In Vivo; mixture=Chemical; chemical_name=Di(2-ethylhexyl) adipate; preferred_name=Bis(2-ethylhexyl)hexanedioate; dtxsid=DTXSID0020606; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020606; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 13.56 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=69; Record_ID=adme_parameters_239; Data_Type=Measured; DTXSID=DTXSID0020606; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=13.56; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
| NTP ICE adme parameters | Fu | 0.03861 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=68; Record_ID=adme_parameters_239; Data_Type=Measured; DTXSID=DTXSID0020606; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.03861; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=238; Record_ID=cancer_1208; Data_Type=WOE; Formulation_Name=Bis(2-ethylhexyl)hexanedioate; Mixture=Chemical; DTXSID=DTXSID0020606; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/95; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
| NTP ICE cancer | Oral slope factor | 0.0012 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=248; Record_ID=cancer_1209; Data_Type=WOE; Formulation_Name=Bis(2-ethylhexyl)hexanedioate; Mixture=Chemical; DTXSID=DTXSID0020606; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=1.1999999999999999E-3; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0420_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
| NTP ICE cancer | Top dose | 25000 | ppm | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=236; Record_ID=cancer_1206; Data_Type=In Vivo; Formulation_Name=Di(2-ethylhexyl) adipate; Mixture=Chemical; DTXSID=DTXSID0020606; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=25000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-212; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr212/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5602; RecordID=ARPathway2016_434; DatasetName=ARPathway2016; DTXSID=DTXSID0020606; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020606; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020606 |
EPA ToxRefDB v3 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =625 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5888; toxval_study_source_id=studyid5888_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=4; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subchronic_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =945 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5889; toxval_study_source_id=studyid5889_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=3; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subchronic_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5885; toxval_study_source_id=studyid5885_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-mortality-mortality; dose_level=4; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1800 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5891; toxval_study_source_id=studyid5891_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hepatocellular carcinoma|pathology microscopic-liver-adenoma/carcinoma combined|in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Chronic_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =3750 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5886; toxval_study_source_id=studyid5886_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-mortality-mortality; dose_level=4; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =2500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5885; toxval_study_source_id=studyid5885_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=5; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =7500 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5886; toxval_study_source_id=studyid5886_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=5; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5891; toxval_study_source_id=studyid5891_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hepatocellular carcinoma|pathology microscopic-liver-adenoma/carcinoma combined|in life observation-body weight-body weight; dose_level=0; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Chronic_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =240 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5889; toxval_study_source_id=studyid5889_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subchronic_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =315 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5888; toxval_study_source_id=studyid5888_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subchronic_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =465 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5889; toxval_study_source_id=studyid5889_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=2; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subchronic_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =600 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5890; toxval_study_source_id=studyid5890_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Chronic_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =625 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5885; toxval_study_source_id=studyid5885_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Rats; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1875 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5886; toxval_study_source_id=studyid5886_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=1982; study_citation=NTP_1982_CARCINOGENESIS BIOASSAY OF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE (FEED STUDY)_Subacute_Mice; dsstox_substance_id=DTXSID0020606; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =60625.9 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2023; ORIGINAL_YEAR=2023; STUDY_GROUP=DOE Protective Action Criteria:15514135:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_505e9a4693cacaf6cc403ef2a4f0f762 |
ECHA 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =2220 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/4500/7/8?documentUUID=b9311bb0-6781-4996-a7d0-93ba7b840b4e; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818876_15819342:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7246640c7b3d38efe351583d13f03ba |
| ECHA | NOAEL | ~170 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6da; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13808/7/9/3?documentUUID=0b0d2c18-50d7-4cdb-9d31-05189faaacdb; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822114_15822297:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d73143402e2bf5ee357135c597a754e5 |
| ECHA | NOAEL | =296 | mg/kg bw/day | Mouse | oral | chronic; 91 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7962; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13808/7/6/2?documentUUID=0b0d2c18-50d7-4cdb-9d31-05189faaacdb; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15839627:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1977ed30d1994b4236c81d1e988fa165 |
| ECHA | NOAEL | =491.4 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7950; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13808/7/6/2?documentUUID=0b0d2c18-50d7-4cdb-9d31-05189faaacdb; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15833254:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6a41b425d282e64af2050689bde35a9 |
| ECHA | NOAEL | =936 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c795a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13808/7/6/2?documentUUID=0b0d2c18-50d7-4cdb-9d31-05189faaacdb; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15837532:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15daed858cb8f0a453b6c1d8620e6ee3 |
| ECHA | NOAEL | >1950 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/4500/7/8?documentUUID=b9311bb0-6781-4996-a7d0-93ba7b840b4e; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15817035:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12bf7d7aea6c8cf6ac0c6f7e7b9cc723 |
| ECHA | NOAEL | =4625 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13808/7/8?documentUUID=0b0d2c18-50d7-4cdb-9d31-05189faaacdb; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818876_15819342:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48aa89d2402a9d5a64d02e591ccf411e |
| ECHA | NOEL | =28 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd263; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16101/7/9/3?documentUUID=1ed5cfc8-ded8-4e1e-8687-0690a60558dc; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15820959:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60aa0672379acfa93d0e510a88131e0b |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15608743:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b2cef53add953300472d81a87815db10 |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =1080 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=ICI (ICI Central Toxicology Laboratory). 1988a. Di-(2-ethylhexyl)adipate: Teratogenicity study in the rat. Report CTL/P/2119 (unpublished study). ; ICI (ICI Central Toxicology Laboratory). 1988b. Di-(2-ethylhexyl)adipate (DEHA) fertility study in rats. Report CTL/P/2229 (unpublished study).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aa4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=420; TOXICOLOGICAL_EFFECT=Reduced ossification and slightly dilated ureters in fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS_dup_IRIS Summary_15644679_15644680:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c076df77159812cc7d10655adedf78d3 |
| ToxValDB IRIS | NOAEL | =170 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=ICI (ICI Central Toxicology Laboratory). 1988a. Di-(2-ethylhexyl)adipate: Teratogenicity study in the rat. Report CTL/P/2119 (unpublished study). ; ICI (ICI Central Toxicology Laboratory). 1988b. Di-(2-ethylhexyl)adipate (DEHA) fertility study in rats. Report CTL/P/2229 (unpublished study).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aa4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=420; TOXICOLOGICAL_EFFECT=Reduced ossification and slightly dilated ureters in fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS_dup_IRIS Summary_15644679_15644680:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_601ea22435985069528f8276589e6172 |
| ToxValDB IRIS | RfD | =0.6 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=ICI (ICI Central Toxicology Laboratory). 1988a. Di-(2-ethylhexyl)adipate: Teratogenicity study in the rat. Report CTL/P/2119 (unpublished study). ; ICI (ICI Central Toxicology Laboratory). 1988b. Di-(2-ethylhexyl)adipate (DEHA) fertility study in rats. Report CTL/P/2229 (unpublished study).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aa4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=420; TOXICOLOGICAL_EFFECT=Changes, total litter weight, and litter size in male/female rats; STUDY_GROUP=IRIS:15644681:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f59b995f924e3093e76e36f63745265e |
ToxValDB ToxRefDB 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =625 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5888; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710140_15710141_15710142_15710143:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2aadeaa3dc10a4b84985fd2362077013 |
| ToxValDB ToxRefDB | LEL | =945 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5889; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710144_15710145:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d4384d363ac08806118fa2f1a768662 |
| ToxValDB ToxRefDB | LEL | =1250 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5885; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710122_15710123_15710124_15710125:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_63b969485a1e6403462a8c0988d0f57e |
| ToxValDB ToxRefDB | LEL | =1800 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Chronic_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5891; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hepatocellular carcinoma; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer; STUDY_GROUP=ToxRefDB_dup_-_15710156_15710157:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6728f60673a35e712e88438e92ddb04c |
| ToxValDB ToxRefDB | LEL | =3750 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5886; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710128_15710129_15710130_15710131:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b7f0019dc2fb56f21b64d44603e21093 |
| ToxValDB ToxRefDB | LOAEL | =2500 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5885; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710122_15710123_15710124_15710125:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b0c5c0586a2aef0a81b0e4b9261be5d0 |
| ToxValDB ToxRefDB | LOAEL | =7500 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5886; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710128_15710129_15710130_15710131:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c8375dbba3b90a24404f1ec2db09329 |
| ToxValDB ToxRefDB | NEL | =240 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5889; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710146_15710147:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15892d344e59cecd61a474b48e709f3b |
| ToxValDB ToxRefDB | NEL | =315 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5888; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710140_15710141_15710142_15710143:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9627531b4c95ccf6dadd5f4677b634a |
| ToxValDB ToxRefDB | NEL | =465 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5889; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710144_15710145:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae715f453295a05bd07ab4e59a22f42d |
| ToxValDB ToxRefDB | NEL | =600 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Chronic_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5890; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710148_15710149_15710150_15710151:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d32a6d2b9d6379171aa1feb48d68e55f |
| ToxValDB ToxRefDB | NEL | =625 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5885; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-mortality-mortality|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710122_15710123_15710124_15710125:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13cc61dcc7dafbaea321909bb22c9b98 |
| ToxValDB ToxRefDB | NEL | =1875 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1982_CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; TITLE=CARCINOGENESIS BIOASSAY\nOF DI(2-ETHYLHEXYL)ADIPATE (CAS NO. 103-23-1) F344 RATS AND B6C3F1 MICE\n(FEED STUDY)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5886; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710128_15710129_15710130_15710131:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b38ea4dcb041f7fcb7f47e19c4c5de5a |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | MBY1SL921L | UNII | - | - | - | chemical | - |