NOAEL Studies
Cosmetic Ingredient
Diethylhexyl Sodium Sulfosuccinate NOAEL Studies
INCI: DIETHYLHEXYL SODIUM SULFOSUCCINATE
CAS: 577-11-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =0.5 | % | rat | oral | 26 weeks | oral toxicity | {"citation":"0; 5; 1","dose":"Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.","effect":"r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_001"} |
| CIR_vision_codex | NOAEL | =0.5 | % | rat | oral | 26 weeks | oral toxicity | {"citation":"0; 5; 1","dose":"Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.","effect":"r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_001"} |
| CIR_vision_codex | NOAEL | =0.5 | % | rat | oral | 26 weeks | oral toxicity | {"citation":"0; 5; 1","dose":"Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.","effect":"r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_001"} |
| CIR_vision_codex | NOAEL | =0.5 | % | rat | oral | 26 weeks | oral toxicity | {"citation":"0; 5; 1","dose":"Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.","effect":"r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_001"} |
| CIR_vision_codex | NOAEL | =1 | % | rat | oral | 14 days | developmental toxicity | {"citation":"0; 1; 2","dose":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.","effect":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_004"} |
| CIR_vision_codex | NOAEL | =1 | % | rat | oral | 14 days | developmental toxicity | {"citation":"0; 1; 2","dose":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.","effect":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_004"} |
| CIR_vision_codex | NOAEL | =1 | % | rat | oral | 14 days | developmental toxicity | {"citation":"0; 1; 2","dose":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.","effect":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_004"} |
| CIR_vision_codex | NOAEL | =1 | % | rat | oral | 14 days | developmental toxicity | {"citation":"0; 1; 2","dose":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.","effect":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_004"} |
| CIR_vision_codex | NOAEL | >30 | mg/kg bw | rabbit | inhalation | 1 year | inhalation toxicity | {"citation":"8; 1; 21","dose":"The NOAEL was >30 mg/kg bw.","effect":"8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_002"} |
| CIR_vision_codex | NOAEL | >30 | mg/kg bw | rabbit | inhalation | 1 year | inhalation toxicity | {"citation":"8; 1; 21","dose":"The NOAEL was >30 mg/kg bw.","effect":"8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_002"} |
| CIR_vision_codex | NOAEL | >30 | mg/kg bw | rabbit | inhalation | 1 year | inhalation toxicity | {"citation":"8; 1; 21","dose":"The NOAEL was >30 mg/kg bw.","effect":"8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_002"} |
| CIR_vision_codex | NOAEL | >30 | mg/kg bw | rabbit | inhalation | 1 year | inhalation toxicity | {"citation":"8; 1; 21","dose":"The NOAEL was >30 mg/kg bw.","effect":"8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...","page":8,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_002"} |
| CIR_vision_codex | NOAEL | =50 | % | rat | oral | - | developmental toxicity | {"citation":"1; 2; 3","effect":"ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...","page":11,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_005"} |
| CIR_vision_codex | NOAEL | =50 | % | rat | oral | - | developmental toxicity | {"citation":"1; 2; 3","effect":"ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...","page":11,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_005"} |
| CIR_vision_codex | NOAEL | =50 | % | rat | oral | - | developmental toxicity | {"citation":"1; 2; 3","effect":"ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...","page":11,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_005"} |
| CIR_vision_codex | NOAEL | =50 | % | rat | oral | - | developmental toxicity | {"citation":"1; 2; 3","effect":"ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...","page":11,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_005"} |
| CIR_vision_codex | NOAEL | =400 | mg/kg bw | rat | oral | - | developmental toxicity | {"citation":"1; 20; 0, 16, 80","dose":"In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...","effect":"developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_003"} |
| CIR_vision_codex | NOAEL | =400 | mg/kg bw | rat | oral | - | developmental toxicity | {"citation":"1; 20; 0, 16, 80","dose":"In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...","effect":"developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_003"} |
| CIR_vision_codex | NOAEL | =400 | mg/kg bw | rat | oral | - | developmental toxicity | {"citation":"1; 20; 0, 16, 80","dose":"In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...","effect":"developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_003"} |
| CIR_vision_codex | NOAEL | =400 | mg/kg bw | rat | oral | - | developmental toxicity | {"citation":"1; 20; 0, 16, 80","dose":"In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...","effect":"developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...","page":9,"pdf":"PRS654.pdf","row_type":"noael_study","study_id":"PRS654_noael_003"} |
COSMOS_DB 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 30 | mg/kg bw/day | dog | oral | 365 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 63 | mg/kg bw/day | rat | oral | 180 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 730 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 574 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 650 | mg/kg bw/day | horse | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 700 | mg/kg bw/day | guinea pig | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 870 | mg/kg bw/day | rat | oral | 168 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 112 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1988 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_adme_parameters 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 49.8 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3186; Record_ID=adme_parameters_996; Data_Type=Measured; DTXSID=DTXSID8022959; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=49.8; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 19.35717708 | uM | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8653; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=19.35717708; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_endocrine | ACC | 19.08508423 | uM | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8652; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=19.08508423; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8654; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_endocrine | Model Score | 0.124 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=8655; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.124; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
NTP_ICE_eye_irritation 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 57 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2361; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=57; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 57 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2361; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=57; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 57 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2361; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=57; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 57 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2361; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=57; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2358; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2358; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2358; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2358; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Intensity | 0.24 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2357; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Intensity | 0.24 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2357; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Intensity | 0.24 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2357; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Intensity | 0.24 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2357; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2362; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2362; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2362; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2362; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Plateau level | 35 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2360; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Plateau level; Response=35; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Plateau level | 35 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2360; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Plateau level; Response=35; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Plateau level | 35 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2360; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Plateau level; Response=35; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
| NTP_ICE_eye_irritation | Plateau level | 35 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2360; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Plateau level; Response=35; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959 |
ToxValDB_ECOTOX 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =0.5 | % | Rat | oral | chronic; 133 days | chronic | LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600624_15600625:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=887502c941c200b75a5a3d4231477eb8 |
| ToxValDB_ECOTOX | LOEL | =260 | mg/kg bw/day | Rat | oral | acute; 0.75 days | acute | LONG_REF=Isr. J. Med. Sci.17(1): 28-35 Rachmilewitz,D., F. Karmeli, and E. Okon Effect of Dioctyl Sodium Sulfosuccinate on Cyclic AMP and Prostaglandin E2 Contents, and Na, K-ATPase, Adenylate Cyclase and Phosphodiesterase Activities in Rat Intestine 1981; TITLE=Effect of Dioctyl Sodium Sulfosuccinate on Cyclic AMP and Prostaglandin E2 Contents, and Na, K-ATPase, Adenylate Cyclase and Phosphodiesterase Activities in Rat Intestine; AUTHOR=Rachmilewitz,D., F. Karmeli, and E. Okon; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119659; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Biochemistry: Prostaglandin E2|Enzyme(s): Sodium potassium ATPase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15594920:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e3c0aa2f5070e55d7d2e898299aba988 |
| ToxValDB_ECOTOX | LOEL | =1500 | mg/kg bw/day | Rat | oral | acute; 0.0417 days | acute | LONG_REF=Chem. Pharm. Bull.34(1): 349-359 Sakurai,E., Y. Kin, G. Fukuse, N. Hikichi, and H. Niwa Effects of Various Cathartics and Deoxycholic Acid on the Disposition of Endogenous Bile Acids in the Bile, Portal Blood and Feces of Rats 1986; TITLE=Effects of Various Cathartics and Deoxycholic Acid on the Disposition of Endogenous Bile Acids in the Bile, Portal Blood and Feces of Rats; AUTHOR=Sakurai,E., Y. Kin, G. Fukuse, N. Hikichi, and H. Niwa; DOI=10.1248/cpb.34.349; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119782; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Bile Acids; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15604780:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b9d06172322840d1d588b2999b4615a3 |
| ToxValDB_ECOTOX | LOEL | =10000 | ppm | Rat | oral | short-term; 7 days | short-term | LONG_REF=J. Natl. Cancer Inst.64(4): 791-793 Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis 1980; TITLE=Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis; AUTHOR=Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen; DOI=10.1093/jnci/64.4.791; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15601087:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e97b6d3e92c5dab1772f96f066496229 |
| ToxValDB_ECOTOX | NOEL | =0.078 | mg/kg bw/day | Rat | oral | chronic; 182.64 days | chronic | LONG_REF=J. Natl. Cancer Inst.64(4): 791-793 Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis 1980; TITLE=Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis; AUTHOR=Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen; DOI=10.1093/jnci/64.4.791; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15601922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=117a35aabd63b2f7b64cd43c569fa59f |
| ToxValDB_ECOTOX | NOEL | =0.1 | % | Rat | oral | chronic; 133 days | chronic | LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600624_15600625:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b012062c39b91b549c91ed8b74feaca |
| ToxValDB_ECOTOX | NOEL | =0.5 | % | Rat | oral | subchronic; 70 days | subchronic | LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597559_15597560:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=afbc614958cfa3648c142c5577331ad5 |
| ToxValDB_ECOTOX | NOEL | =1 | % | Rat | oral | chronic; 322 days | chronic | LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Population: Sex ratio; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595224_15605344_15605345_15606738_15606739:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=743f03b717f58c871210522130a4c39f |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1889.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634749:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdb8e5d84c833dc7588c9105e2f4eb23 |
UnifiedCodex:CIR:beta.noael_studies 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 1 | % | rat | oral | 14 days | developmental toxicity | SOURCE_SUBDIR=PRS654; REPORT_TITLE=Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS654; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2016; VALUE_TEXT=1; DOSE=gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.; EFFECT=gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...; CITATION=0; 1; 2; CITATION_NUMBERS=[1,2]; REFERENCE=0; 1; 2; DETAILS_JSON={"cas_number":"577-11-7","citation":"0; 1; 2","dose":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group.","duration":"14 days","effect":"gue Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of resorptions and gross abnormal- ities,primarilyexencephalyand,attimes,spinabifida,anophthal- mia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. Groups of 30 female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate once daily for 14 days prior to mating with untreated males; one-half of the animals in each group were dosed until day 13 of gestation, at which time the animals were killed, and the remaining animals were dosed until parturition and were not killed.4 No effects on reproductive para- meters, fertility, or pup weight and condition were observed. The parental N...","endpoint":"developmental toxicity","ingredient":"Dialkyl Sulfosuccinate Salts","loael_value":"","noael_unit":"%","noael_value":"1","page":9,"route":"oral","species":"rat","study_id":"PRS654_noael_004"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 50 | % | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS654; REPORT_TITLE=Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS654; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2016; VALUE_TEXT=50; EFFECT=ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...; CITATION=1; 2; 3; CITATION_NUMBERS=[1,2,3]; REFERENCE=1; 2; 3; DETAILS_JSON={"cas_number":"577-11-7","citation":"1; 2; 3","dose":"","duration":"","effect":"ffects on maternal or fetal parameters were observed in the 1% test group, but in the 2% test group, significant incidences of resorptions and gross abnormalities, primarily exencephaly and, at times, spina bifida, anophthalmia, and associated skeletal defects, were reported. The NOAEL for maternal toxicity and teratogenic effects was 1%. In a 3-generation study in which rats were fed a diet containing up to 1% of a test substance containing 50% diethylhexyl sodium sulfosuccinate in aq. beverage-grade etha- nol, a NOEL for parental toxicity and effects on pups was not established because of reduced body weight gains in the parents and reduced viability indices in the pups, but the NOEL for reproduction was 1%; the reduced viability index most likely was attributed to the pups discontinuing nursing because they could taste the test article. In rats, a diet containing 1% diethylhexyl sodium sulfosuc- cinate did not have an effect on 1,2-dimethylhydrazine- induced colorectal carcinogenesis. In clinical studies, 2.5% diethylhexyl sodium sulfosuccinate was an irritant, but not a sensit...","endpoint":"developmental toxicity","ingredient":"Dialkyl Sulfosuccinate Salts","loael_value":"","noael_unit":"%","noael_value":"50","page":11,"route":"oral","species":"rat","study_id":"PRS654_noael_005"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 400 | mg/kg bw | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS654; REPORT_TITLE=Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS654; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2016; VALUE_TEXT=400; DOSE=In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...; EFFECT=developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...; CITATION=1; 20; 0, 16, 80; CITATION_NUMBERS=[1,20,16,80]; REFERENCE=1; 20; 0, 16, 80; DETAILS_JSON={"cas_number":"577-11-7","citation":"1; 20; 0, 16, 80","dose":"In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and kil...","duration":"","effect":"developmental toxicity data from the original safety assessment on diethylhexyl sodium sulfo- succinate are available in Table 1. In developmental toxicity studies, groups of 20 gravid female mice and 20 gravid female rats were dosed by gavage with 0, 16, 80, or 400 mg/kg bw of a test substance containing 0.4% (w/v) diethylhexyl sodium sul- fosuccinate.4 The mice were dosed on days 6 to 15 and killed on day 17 of gestation and the rats were dosed on days 5 to 19 of gestation and killed on day 20 of gestation. The NOAEL for maternal toxicity and teratogenic effects for both mice and rats was 400 mg/kg bw of the test substance containing 0.4% (w/v) diethylhexyl sodium sulfosuccinate. Groups of 20 to 39 gravid female Sprague Dawley rats were fed a diet containing 0%, 1%, or 2% diethylhexyl sodium sulfo- succinate (equivalent to 0, 1,074, and 1,983 mg/kg bw, respec- tively) on days 6 to 15 of gestation, and the dams were killed on day 21 of gestation.4 No adverse effects on maternal or fetal parameters were observed in the 1% test group. In the 2% test group, significant incidences of...","endpoint":"developmental toxicity","ingredient":"Dialkyl Sulfosuccinate Salts","loael_value":"","noael_unit":"mg/kg bw","noael_value":"400","page":9,"route":"oral","species":"rat","study_id":"PRS654_noael_003"} |
| UnifiedCodex:CIR:beta.noael_studies | inhalation toxicity | >30 | mg/kg bw | rabbit | inhalation | 1 year | inhalation toxicity | SOURCE_SUBDIR=PRS654; REPORT_TITLE=Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS654; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2016; VALUE_TEXT=> 30; DOSE=The NOAEL was >30 mg/kg bw.; EFFECT=8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...; CITATION=8; 1; 21; CITATION_NUMBERS=[8,1,21]; REFERENCE=8; 1; 21; DETAILS_JSON={"cas_number":"577-11-7","citation":"8; 1; 21","dose":"The NOAEL was >30 mg/kg bw.","duration":"1 year","effect":"8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were measured at various intervals. No signs of toxicity were observed in any of the groups. Diethylhexyl sodium sulfosuccinate, alone and in combination with 1,8- dihydroxyanthraquinone, did not have any adverse effects on urinalysis, hematological or clinical parameters, or body weights, and it did not induce any gross or microscopic lesions. The NOAEL was >30 mg/kg bw. Inhalation. Repeated-dose inhalation toxicity data from the orig- inal safety assessment on diethylhexyl sodium sulfosuccinate are available in Table 1. Fluorescent latex particles, 0.63-mm diameter, were admi- nistered in aerosol form to 30 rabbits.24 Six rabbits were killed immediately after administration of the fluorescent particles (baseline group); 12 rabbits were given a diethylhexyl sodium sulfosuccinate aerosol prepared as a 2% solution in equal volumes of ethanol and physiological saline (detergent group) and 12 were given vehicle aeroso...","endpoint":"inhalation toxicity","ingredient":"Dialkyl Sulfosuccinate Salts","loael_value":"","noael_unit":"mg/kg bw","noael_value":"> 30","page":8,"route":"inhalation","species":"rabbit","study_id":"PRS654_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | oral toxicity | 0.5 | % | rat | oral | 26 weeks | oral toxicity | SOURCE_SUBDIR=PRS654; REPORT_TITLE=Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks Jr3, Ronald C. Shank3,; OPINION_NUMBER=PRS654; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Toxicology 2016; VALUE_TEXT=0.5; DOSE=Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.; EFFECT=r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...; CITATION=0; 5; 1; CITATION_NUMBERS=[5,1]; REFERENCE=0; 5; 1; DETAILS_JSON={"cas_number":"577-11-7","citation":"0; 5; 1","dose":"Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3.","duration":"26 weeks","effect":"r microscopic findings. Differences in body weights or organ weights compared to controls were not statistically significant. Twelve rats/group were fed a diet containing 0%, 0.5%, 1.04%, or 1.5% diethylhexyl sodium sulfosuccinate for 26 weeks.23 Body weight gains of females of the 1.04% and 1.5% dose groups were decreased during week 3. Two control animals and 4 animals of the 1.5% group died during the study; 2 of the 4 animals of the 1.5% group had hemorrhagic gastro- enteritis. No other effects were noted. The no-observable adverse effect level (NOAEL) was 0.5%, and the lowest- observable adverse effect level was 1.04%. Groups of 4 male and 4 female beagle dogs were dosed orally with tablets containing 30 mg/kg bw diethylhexyl sodium sulfosuccinate, 10 mg/kg bw diethylhexyl sodium sulfosuccinate þ 5 mg/kg bw 1,8-dihydroxyanthraquinone, or 30 mg/kg bw diethylhexyl sodium sulfosuccinate, and 15 mg/kg bw 1,8-dihydroxyanthraquinone, daily, for 1 year.21 A control group was given a placebo tablet. Urinalysis was performed, and hematological and clinical chemistry parameters were me...","endpoint":"oral toxicity","ingredient":"Dialkyl Sulfosuccinate Salts","loael_value":"","noael_unit":"%","noael_value":"0.5","page":8,"route":"oral","species":"rat","study_id":"PRS654_noael_001"} |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | F05Q2T2JA0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H37O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F05Q2T2JA0"} |
| openFDA substances | FDA UNII substance identifier | F05Q2T2JA0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H37O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F05Q2T2JA0"} |
| openFDA substances | FDA UNII substance identifier | F05Q2T2JA0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H37O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F05Q2T2JA0"} |
| openFDA substances | FDA UNII substance identifier | F05Q2T2JA0 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H37O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F05Q2T2JA0"} |