NOAEL Studies Cosmetic Ingredient

Diethylhexyl Sodium Sulfosuccinate NOAEL Studies

INCI: DIETHYLHEXYL SODIUM SULFOSUCCINATE

CAS: 577-11-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =0.5 % rat oral 26 weeks oral toxicity 0; 5; 1, p.8
CIR Safety Assessment NOAEL =1 % rat oral 14 days developmental toxicity 0; 1; 2, p.9
CIR Safety Assessment NOAEL >30 mg/kg bw rabbit inhalation 1 year inhalation toxicity 8; 1; 21, p.8
CIR Safety Assessment NOAEL =50 % rat oral - developmental toxicity 1; 2; 3, p.11
CIR Safety Assessment NOAEL =400 mg/kg bw rat oral - developmental toxicity 1; 20; 0, 16, 80, p.9
COSMOS DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 30 mg/kg bw/day dog oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 63 mg/kg bw/day rat oral 180 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 574 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 650 mg/kg bw/day horse oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 700 mg/kg bw/day guinea pig oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 870 mg/kg bw/day rat oral 168 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1988 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE adme parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 49.8 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3186; Record_ID=adme_parameters_996; Data_Type=Measured; DTXSID=DTXSID8022959; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=49.8; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 19.35717708 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8653; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=19.35717708; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE endocrine ACC 19.08508423 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8652; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=19.08508423; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8654; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE endocrine Model Score 0.124 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8655; RecordID=ARPathway2016_371; DatasetName=ARPathway2016; DTXSID=DTXSID8022959; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.124; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE eye irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 57 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2361; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=57; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE eye irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2358; Record_ID=eye_irritation_208; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE eye irritation Intensity 0.24 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2357; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE eye irritation Lag time 0 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2362; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
NTP ICE eye irritation Plateau level 35 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2360; Record_ID=eye_irritation_1314; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022959; Assay=Vitrigel; Endpoint=Plateau level; Response=35; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022959
ToxValDB ECOTOX 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =0.5 % Rat oral chronic; 133 days chronic LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600624_15600625:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=887502c941c200b75a5a3d4231477eb8
ToxValDB ECOTOX LOEL =260 mg/kg bw/day Rat oral acute; 0.75 days acute LONG_REF=Isr. J. Med. Sci.17(1): 28-35 Rachmilewitz,D., F. Karmeli, and E. Okon Effect of Dioctyl Sodium Sulfosuccinate on Cyclic AMP and Prostaglandin E2 Contents, and Na, K-ATPase, Adenylate Cyclase and Phosphodiesterase Activities in Rat Intestine 1981; TITLE=Effect of Dioctyl Sodium Sulfosuccinate on Cyclic AMP and Prostaglandin E2 Contents, and Na, K-ATPase, Adenylate Cyclase and Phosphodiesterase Activities in Rat Intestine; AUTHOR=Rachmilewitz,D., F. Karmeli, and E. Okon; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119659; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Biochemistry: Prostaglandin E2|Enzyme(s): Sodium potassium ATPase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15594920:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e3c0aa2f5070e55d7d2e898299aba988
ToxValDB ECOTOX LOEL =1500 mg/kg bw/day Rat oral acute; 0.0417 days acute LONG_REF=Chem. Pharm. Bull.34(1): 349-359 Sakurai,E., Y. Kin, G. Fukuse, N. Hikichi, and H. Niwa Effects of Various Cathartics and Deoxycholic Acid on the Disposition of Endogenous Bile Acids in the Bile, Portal Blood and Feces of Rats 1986; TITLE=Effects of Various Cathartics and Deoxycholic Acid on the Disposition of Endogenous Bile Acids in the Bile, Portal Blood and Feces of Rats; AUTHOR=Sakurai,E., Y. Kin, G. Fukuse, N. Hikichi, and H. Niwa; DOI=10.1248/cpb.34.349; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119782; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Bile Acids; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15604780:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b9d06172322840d1d588b2999b4615a3
ToxValDB ECOTOX LOEL =10000 ppm Rat oral short-term; 7 days short-term LONG_REF=J. Natl. Cancer Inst.64(4): 791-793 Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis 1980; TITLE=Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis; AUTHOR=Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen; DOI=10.1093/jnci/64.4.791; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15601087:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e97b6d3e92c5dab1772f96f066496229
ToxValDB ECOTOX NOEL =0.078 mg/kg bw/day Rat oral chronic; 182.64 days chronic LONG_REF=J. Natl. Cancer Inst.64(4): 791-793 Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis 1980; TITLE=Effect of Dioctyl Sodium Sulfosuccinate Feeding on Rat Colorectal 1,2-Dimethylhydrazine Carcinogenesis; AUTHOR=Karlin,D.A., R.T. O\'Donnell, and W.E. Jensen; DOI=10.1093/jnci/64.4.791; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15601922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=117a35aabd63b2f7b64cd43c569fa59f
ToxValDB ECOTOX NOEL =0.1 % Rat oral chronic; 133 days chronic LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600624_15600625:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b012062c39b91b549c91ed8b74feaca
ToxValDB ECOTOX NOEL =0.5 % Rat oral subchronic; 70 days subchronic LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597559_15597560:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=afbc614958cfa3648c142c5577331ad5
ToxValDB ECOTOX NOEL =1 % Rat oral chronic; 322 days chronic LONG_REF=Fundam. Appl. Toxicol.15(1): 53-62 MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats 1990; TITLE=Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats; AUTHOR=MacKenzie,K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, and G. McKinney; DOI=10.1016/0272-0590(90)90162-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Population: Sex ratio; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595224_15605344_15605345_15606738_15606739:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=743f03b717f58c871210522130a4c39f
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1889.1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634749:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdb8e5d84c833dc7588c9105e2f4eb23
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 1 % rat oral 14 days developmental toxicity p.9
Regulatory source developmental toxicity 50 % rat oral - developmental toxicity p.11
Regulatory source developmental toxicity 400 mg/kg bw rat oral - developmental toxicity p.9
Regulatory source inhalation toxicity >30 mg/kg bw rabbit inhalation 1 year inhalation toxicity p.8
Regulatory source oral toxicity 0.5 % rat oral 26 weeks oral toxicity p.8
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier F05Q2T2JA0 UNII - - - chemical -