Good Cosmetic Ingredient NOAEL Data

Dihydrocitronellyl Acetate

INCI: DIHYDROCITRONELLYL ACETATE

CAS Number
20780-49-8
Function
Fragrance
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR restriction; FEMA GRAS for flavour use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Dihydrocitronellyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Metabolic hydrolysis to dihydrocitronellol possible with potential allergen cross-reactivity. Widely used in fragrance compositions with long safety-in-commerce history. IFRA does not currently restrict this ingredient.

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Dihydrocitronellyl Acetate safe in cosmetics?

Metabolic hydrolysis to dihydrocitronellol possible with potential allergen cross-reactivity. Widely used in fragrance compositions with long safety-in-commerce history. IFRA does not currently restrict this ingredient. The EU classifies Dihydrocitronellyl Acetate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Dihydrocitronellyl Acetate allowed in the EU?

Dihydrocitronellyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydrocitronellyl Acetate do in cosmetics?

Dihydrocitronellyl Acetate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 20780-49-8.

What is the Margin of Safety for Dihydrocitronellyl Acetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dihydrocitronellyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Dihydrocitronellyl Acetate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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