Is Citronellyl Formate safe in cosmetics?
Citronellyl Formate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Citronellyl Formate
Also known as: 6-Octen-1-ol, 3,7-dimethyl-, formate, 3,7-Dimethyloct-6-en-1-yl formate, 6-Octen-1-ol, 3,7-dimethyl-, 1-formate, 2-02-00-00032, BRN 1723215 (+13 more)
INCI: CITRONELLYL FORMATE
Citronellyl Formate (CAS 105-85-1) is a cosmetic cosmetic ingredient functioning as Fragrance / Flavoring Agent. NOAEL 800 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 105-85-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / Flavoring Agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,7-dimethyloct-6-enyl formate
InChIKey
DZNVIZQPWLDQHI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-listed as food substance; CIR deferred to RIFM as fragrance; FEMA GRAS listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citronellyl Formate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Citronellyl Formate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Citronellyl Formate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Number
53
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Citronellyl Formate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Citronellyl Formate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
6-Octen-1-ol, 3,7-dimethyl-, formate
3,7-Dimethyloct-6-en-1-yl formate
6-Octen-1-ol, 3,7-dimethyl-, 1-formate
2-02-00-00032
BRN 1723215
Citronellol formate
Citronellyl methanoate
2,6-Dimethyl-2-octen-8-yl formate
3,7-Dimethyl-6-octen-1-yl formate
3,7-Dimethyl-6-octen-1-yl methanoate
EINECS 203-338-9
EINECS 300-075-2
FEMA No. 2314
Formic acid, citronellyl ester
Formic acid, 3,7-dimethyl-6-octen-1-yl ester
NSC 46117
Rhodinyl formate
UNII-7B1MY2BRDK
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; Cleaning products and household care - air freshener; detected; emissions; Europe
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184928
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CITRONELLYL FORMATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Citronellyl Formate allowed in the EU?
Citronellyl Formate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Citronellyl Formate do in cosmetics?
Citronellyl Formate functions as: Fragrance / Flavoring Agent. It is classified as a cosmetic ingredient in our database. CAS number: 105-85-1.
What is the NOAEL for Citronellyl Formate?
The NOAEL (No Observed Adverse Effect Level) for Citronellyl Formate is =300 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Citronellyl Formate used outside cosmetics?
Citronellyl Formate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Citronellyl Formate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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