Good Cosmetic Ingredient NOAEL Data

Citronellyl Formate

INCI: CITRONELLYL FORMATE

CAS Number
105-85-1
Function
Fragrance / Flavoring Agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA-listed as food substance; CIR deferred to RIFM as fragrance; FEMA GRAS listed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Citronellyl Formate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 800 mg/kg bw/day oral rat oral REACH
LOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Skin irritant (H315); Eye irritant (H319); STOT SE 3 (H335); initial Ames positive in plate incorporation for TA100 but confirmed negative in follow-up Ames and HPRT โ€” not considered mutagenic

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Citronellyl Formate safe in cosmetics?

Skin irritant (H315); Eye irritant (H319); STOT SE 3 (H335); initial Ames positive in plate incorporation for TA100 but confirmed negative in follow-up Ames and HPRT โ€” not considered mutagenic The EU classifies Citronellyl Formate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Citronellyl Formate allowed in the EU?

Citronellyl Formate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citronellyl Formate do in cosmetics?

Citronellyl Formate functions as: Fragrance / Flavoring Agent. It is classified as a cosmetic ingredient in our database. CAS number: 105-85-1.

What is the Margin of Safety for Citronellyl Formate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citronellyl Formate?

The NOAEL (No Observed Adverse Effect Level) for Citronellyl Formate is 800 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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