NOAEL Studies Cosmetic Ingredient

Dihydroeugenol NOAEL Studies

INCI: DIHYDROEUGENOL

CAS: 2785-87-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =67 mg/kg bw/day Rat oral: unspecified 90 days subchronic ENDPOINTSTUDY_ID 690611; TOX_ID 417 - OP_ID 201 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of Scansmoke SEF7525 (smoke flavourings) for cats and dogs - doi:10.2903/j.efsa.2012.2729
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =67 mg/kg bw/day Rat oral: unspecified 90 days subchronic ENDPOINTSTUDY_ID 690611; TOX_ID 417 - OP_ID 201 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of Scansmoke SEF7525 (smoke flavourings) for cats and dogs - doi:10.2903/j.efsa.2012.2729
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_4965; row=4858; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxy-4-propylphenol; preferred_name=2-Methoxy-4-propylphenol; dtxsid=DTXSID2047199; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 24.6 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1066; Record_ID=adme_parameters_822; Data_Type=Measured; DTXSID=DTXSID2047199; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=24.6; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_adme_parameters Fu 0.0707 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1067; Record_ID=adme_parameters_822; Data_Type=Measured; DTXSID=DTXSID2047199; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0707; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Depletion Cys 0 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=87; Record_ID=skin_sensitization_invitro_10; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization Depletion Lys 12.3 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=142; Record_ID=skin_sensitization_invitro_10; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=12.3; Reported_Response_Unit=%; Response=12.3; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization EC1.5 462 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8792; Record_ID=skin_sensitization_invitro_2435; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=462.011507; Reported_Response_Unit=uM; Response=462; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization EC3 6.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13104; Record_ID=skin_sensitization_invivo_3102; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=LLNA; Endpoint=EC3; Response=6.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization IC50 759.2 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8793; Record_ID=skin_sensitization_invitro_2435; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=759.1661078; Reported_Response_Unit=uM; Response=759.2; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization Imax 1.539 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8794; Record_ID=skin_sensitization_invitro_2435; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.539323235; Reported_Response_Unit=Unitless; Response=1.539; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6546; Record_ID=skin_sensitization_invivo_1496; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization Induction dose per skin area 5400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6544; Record_ID=skin_sensitization_invivo_1496; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=6550; Record_ID=skin_sensitization_invivo_1496; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2047199; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2047199
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =6.07 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633287:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b50a4c214033452e8bae7b9dcf22c02
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier A3XE712277 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A3XE712277"}
openFDA substances FDA UNII substance identifier A3XE712277 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A3XE712277"}
openFDA substances FDA UNII substance identifier A3XE712277 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A3XE712277"}
openFDA substances FDA UNII substance identifier A3XE712277 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A3XE712277"}