NOAEL Studies Cosmetic Ingredient

DIHYDROXYINDOLE NOAEL Studies

CAS: 3131-52-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 91 day Subchronic SCCP; L. Vallet. 13-Week Toxicity Study by Oral Route (Gavage) in Rats. CIT Study No. 7702TCR, 1992
COSMOS DB NOAEL 3 mg/kg bw/day rat oral 91 day Subchronic SCCP; L. Vallet. 13-Week Toxicity Study by Oral Route (Gavage) in Rats. CIT Study No. 7702TCR, 1992
SCCNFP Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =3 mg/kg bw/day rat dermal Sub-chronic repeated dose toxicity Ref. : 5 2, p.8
SCCNFP Opinion NOAEL =3 mg/kg rat oral 13 weeks dermal absorption p.16
SCCNFP Opinion NOAEL =3 mg/kg/day rat - 13-week NOAEL study Ref: 93/02/03 (Feb 1993) 3, p.18
SCCNFP Opinion NOAEL =10 mg/kg bw/day rat dermal Sub-chronic repeated dose toxicity Ref. : 5 2, p.8
SCCNFP Opinion NOAEL =100 mg/kg bw/day rat - - developmental toxicity Ref. : 13 2, p.12
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.012 mg/kg rat dermal 13-week dermal absorption p.23
SCCS Opinion NOAEL =1.5 mg/kg bw/d - - Chronic NOAEL study p.15
SCCS Opinion NOAEL =1.5 mg/kg rat dermal 13-week dermal absorption p.23
SCCS Opinion NOAEL =3 mg/kg bw/day rat - - NOAEL study p.14
SCCS Opinion NOAEL =10 mg/kg bw/day rat - - NOAEL study p.14
SCCS Opinion NOAEL =15 mg/kg bw/d rat dermal - reproductive toxicity p.21
SCCS Opinion NOAEL =100 mg/kg bw/day rat - developmental reproductive toxicity p.20
SCCS Opinion NOAEL =500 mg/kg bw rat oral subchronic repeated dose toxicity p.24
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 3 mg/kg/day rat - 13-week - p.18
Regulatory source - 3 mg/kg rat oral 13 weeks - p.16
Regulatory source - 10 mg/kg bw/day rat oral 13-week - p.17
Regulatory source dermal absorption =3 mg/kg rat oral 13 weeks dermal absorption p.16
Regulatory source developmental toxicity 3 mg/kg bw/day rat - 4-week developmental toxicity p.17
Regulatory source developmental toxicity 10 mg/kg bw/day rat oral 13-week developmental toxicity p.17
Regulatory source developmental toxicity 100 mg/kg bw/day rat - - developmental toxicity p.12
Regulatory source repeated dose toxicity 3 mg/kg bw/day rat dermal Sub-chronic repeated dose toxicity p.8
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat dermal Sub-chronic repeated dose toxicity p.8
Regulatory source - 1.5 mg/kg bw/d - - Chronic - p.15
Regulatory source - 3 mg/kg bw/day rat - - - p.14
Regulatory source - 10 mg/kg bw/day rat - - - p.14
Regulatory source dermal absorption =0.012 mg/kg rat dermal 13-week dermal absorption p.23
Regulatory source dermal absorption =1.5 mg/kg rat dermal 13-week dermal absorption p.23
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat oral subchronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity 500 mg/kg bw rat oral subchronic repeated dose toxicity p.24
Regulatory source reproductive toxicity 15 mg/kg bw/d rat dermal - reproductive toxicity p.21
Regulatory source reproductive toxicity 100 mg/kg bw/day rat - developmental reproductive toxicity p.20
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Z3OC8499KG UNII - - - chemical -