NOAEL Studies Cosmetic Ingredient

Dihydroxyindoline NOAEL Studies

INCI: DIHYDROXYINDOLINE

CAS: 29539-03-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 20 mg/kg bw/day rat oral 13 week Subchronic SCCNFP; Pharmakon Europe, France. Study No 328/512; Henkel KGaA Report No 9501030 (1995)
COSMOS DB NOAEL 10 mg/kg bw/day rat oral 13 week Subchronic SCCNFP; Pharmakon Europe, France. Study No 328/512; Henkel KGaA Report No 9501030 (1995)
SCCNFP Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =2 % rat oral subchronic repeated dose toxicity p.18
SCCNFP Opinion NOAEL =10 mg/kg/day rat dermal Sub-chronic repeated dose toxicity Ref. : 19 2, p.9
SCCNFP Opinion NOAEL =10 mg/kg rat oral 90 day dermal absorption p.18
SCCNFP Opinion NOAEL =10 mg/kg bw/day rat oral subchronic repeated dose toxicity p.18
SCCNFP Opinion NOAEL =20 mg/kg bw/day rat - - NOAEL study Ref. : 13, p.7
SCCNFP Opinion NOAEL =180 mg/kg bw/day rat - 4 weeks NOAEL study p.7
SCCNFP Opinion NOAEL =240 mg/kg bw/day rat dermal - dermal absorption Ref. : 15, 16 2, p.13
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg bw/day rat - - - p.7
Regulatory source - 180 mg/kg bw/day rat - 4 weeks - p.7
Regulatory source dermal absorption =10 mg/kg rat oral 90 day dermal absorption p.18
Regulatory source dermal absorption 240 mg/kg bw/day rat dermal - dermal absorption p.13
Regulatory source repeated dose toxicity 2 % rat oral subchronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 10 mg/kg/day rat dermal Sub-chronic repeated dose toxicity p.9
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat oral subchronic repeated dose toxicity p.18
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HH49N58FJ9 UNII - - - chemical -