NOAEL Studies Cosmetic Ingredient

Diisobutyl Sodium Sulfosuccinate NOAEL Studies

INCI: DIISOBUTYL SODIUM SULFOSUCCINATE

CAS: 127-39-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2772 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_2074; row=12077; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium 1,4-diisobutyl sulfosuccinate; preferred_name=Sodium 1,4-diisobutyl sulfosuccinate; dtxsid=DTXSID7029164; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029164; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6160 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_2076; row=12078; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium 1,4-diisobutyl sulfosuccinate; preferred_name=Sodium 1,4-diisobutyl sulfosuccinate; dtxsid=DTXSID7029164; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029164; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=14348; RecordID=ARPathway2016_757; DatasetName=ARPathway2016; DTXSID=DTXSID7029164; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029164
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =750 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2c73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5519/7/6/2?documentUUID=de95b3d1-498b-4583-85a0-ce4cdf2bc0d2; STUDY_GROUP=ECHA IUCLID:15833911:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_292d8b4ea7503f0815d482f2cf50cc1d
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2c75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5519/7/6/2?documentUUID=de95b3d1-498b-4583-85a0-ce4cdf2bc0d2; STUDY_GROUP=ECHA IUCLID:15842582:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15963c0bdc76a28aacc5e1c0b6b61047
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1889.1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634783:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ea75ed8fb6e5f4d4566bbaafe2d27e4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B51N789L6J UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H21O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B51N789L6J"}
openFDA substances FDA UNII substance identifier B51N789L6J UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H21O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B51N789L6J"}
openFDA substances FDA UNII substance identifier B51N789L6J UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H21O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B51N789L6J"}
openFDA substances FDA UNII substance identifier B51N789L6J UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H21O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B51N789L6J"}