Poor Cosmetic Ingredient NOAEL Data

Dimethyl Imidazolidinone

INCI: DIMETHYL IMIDAZOLIDINONE

CAS Number
80-73-9
Function
Humectant, skin conditioning, solvent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted with no specific CFR prohibition, but not widely used in cosmetics due to toxicity profile.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Dimethyl Imidazolidinone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 6 mg/kg bw/day oral rat oral REACH
NOEL 20 mg/kg bw/day oral rat oral REACH

Expert Verdict

Suspected reproductive toxicant (Category 2); STOT RE 2 targeting testes; serious eye damage hazard; harmful if swallowed; should be avoided in cosmetic formulations without extensive justification.

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Concern Level: High

Frequently Asked Questions

Is Dimethyl Imidazolidinone safe in cosmetics?

Suspected reproductive toxicant (Category 2); STOT RE 2 targeting testes; serious eye damage hazard; harmful if swallowed; should be avoided in cosmetic formulations without extensive justification. The EU classifies Dimethyl Imidazolidinone as "permitted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is Dimethyl Imidazolidinone allowed in the EU?

Dimethyl Imidazolidinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethyl Imidazolidinone do in cosmetics?

Dimethyl Imidazolidinone functions as: Humectant, skin conditioning, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 80-73-9.

What is the Margin of Safety for Dimethyl Imidazolidinone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dimethyl Imidazolidinone?

The NOAEL (No Observed Adverse Effect Level) for Dimethyl Imidazolidinone is 6 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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