NOAEL Studies Cosmetic Ingredient

Dimethyl Isopropanolamine NOAEL Studies

INCI: DIMETHYL ISOPROPANOLAMINE

CAS: 108-16-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1739 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_704; row=8988; data_type=In Vivo; mixture=Chemical; chemical_name=Dimepranol; preferred_name=Dimepranol; dtxsid=DTXSID5031210; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5031210; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5031210; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =750 mg/kg bw/day Rat oral short-term; 15 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ffa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12061/7/6/2?documentUUID=3491ffaf-f01f-4ea0-9805-e27e805ff6a9; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|gross pathology|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836100_15836101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_88b0209c356ad211dd585ccaadd6de1b
ToxValDB_ECHA_IUCLID LOAEL =240 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ffb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12061/7/6/2?documentUUID=3491ffaf-f01f-4ea0-9805-e27e805ff6a9; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841085_15841086_15841087:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ffaf1b8d6759f6e0400db791b64406a
ToxValDB_ECHA_IUCLID NOAEL =240 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12061/7/9/3?documentUUID=3491ffaf-f01f-4ea0-9805-e27e805ff6a9; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15821814:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7142684937b2f4d73507d35ae48e221f
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral short-term; 15 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ffa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12061/7/6/2?documentUUID=3491ffaf-f01f-4ea0-9805-e27e805ff6a9; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836100_15836101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e578d4b03ec6ae494679d64cb9b4ce8e
ToxValDB_ECHA_IUCLID NOAEL =120 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ffb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12061/7/6/2?documentUUID=3491ffaf-f01f-4ea0-9805-e27e805ff6a9; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841085_15841086_15841087:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65be78ed78ab93f5abb4ff7c2c5f5a8f
ToxValDB_EPA_TSCA_8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e NEL =100 mg/kg bw/day Rat oral short-term; 15 days short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21476_10.05.18_Combined.pdf; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15956512_15956513:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d8723871216f4b27187d3f57cce9a86
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631303:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47f6a3c157d96b7f6d490c91a0d4b82e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier OX17195H4T UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H13NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OX17195H4T"}
openFDA substances FDA UNII substance identifier OX17195H4T UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H13NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OX17195H4T"}
openFDA substances FDA UNII substance identifier OX17195H4T UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H13NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OX17195H4T"}
openFDA substances FDA UNII substance identifier OX17195H4T UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H13NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OX17195H4T"}