Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dimethyl Isopropanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 120 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 750 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Nitrosamine formation risk in presence of nitrite/nitrosating agents; must be stored in nitrite-free containers; limited use-concentration data specific to DMIPA versus di- and triisopropanolamine.
Frequently Asked Questions
Is Dimethyl Isopropanolamine safe in cosmetics?
Nitrosamine formation risk in presence of nitrite/nitrosating agents; must be stored in nitrite-free containers; limited use-concentration data specific to DMIPA versus di- and triisopropanolamine. The EU classifies Dimethyl Isopropanolamine as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Dimethyl Isopropanolamine allowed in the EU?
Dimethyl Isopropanolamine EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Isopropanolamine do in cosmetics?
Dimethyl Isopropanolamine functions as: Buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-16-7.
What is the Margin of Safety for Dimethyl Isopropanolamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Isopropanolamine?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Isopropanolamine is 120 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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