Is Dimethyl Isopropanolamine safe in cosmetics?
Dimethyl Isopropanolamine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Dimethyl Isopropanolamine
Also known as: 2-Propanol, 1-(dimethylamino)-, (±)-1-(Dimethylamino)-2-propanol, Dimethylaminoisopropanol, 4-04-00-01666, BRN 1209244 (+12 more)
INCI: DIMETHYL ISOPROPANOLAMINE
Dimethyl Isopropanolamine (CAS 108-16-7) is a cosmetic cosmetic ingredient functioning as Buffering agent, pH adjuster. NOAEL 120 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-16-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyl Isopropanolamine is classified GHS Danger (H226, H302, H312, H314, H318) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering agent, pH adjuster
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(dimethylamino)propan-2-ol
InChIKey
NCXUNZWLEYGQAH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
Permitted — isopropanolamines group reviewed by CIR; safe at reported use concentrations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Isopropanolamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Dimethyl Isopropanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =120 mg/kg bw/day | oral | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =240 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dimethyl Isopropanolamine across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H226 Flammable liquid and vapour
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Isopropanolamine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethyl Isopropanolamine by CAS number or substance name.
Studies
3
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propanol, 1-(dimethylamino)-
(±)-1-(Dimethylamino)-2-propanol
Dimethylaminoisopropanol
4-04-00-01666
BRN 1209244
N,N-(Dimethylamino)-2-propanol
1,1-Dimethylaminopropanol-2
1-(Dimethylamino)-2-propanol
N,N-Dimethyl-2-hydroxypropylamine
Dimethyl(2-hydroxypropyl)amine
Dimethylisopropanolamine
EINECS 203-556-4
NSC 3163
2-Propanol, 1,1-(dimethylamino)-
Dimepranolum
UNII-OX17195H4T
DMIPA
Chemical Function
pH regulating agent
Regulatory Lists
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186209
Frequently Asked Questions
Is Dimethyl Isopropanolamine allowed in the EU?
Dimethyl Isopropanolamine EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Isopropanolamine do in cosmetics?
Dimethyl Isopropanolamine functions as: Buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-16-7.
What is the NOAEL for Dimethyl Isopropanolamine?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Isopropanolamine is =120 mg/kg bw/day based on a acute study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Dimethyl Isopropanolamine used outside cosmetics?
Dimethyl Isopropanolamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Isopropanolamine have different safety status in cosmetics vs industrial chemicals?
Dimethyl Isopropanolamine is classified GHS Danger (H226, H302, H312, H314, H318) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Compliance Tools
Check Dimethyl Isopropanolamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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