NOAEL Studies
Cosmetic Ingredient
Dimethyl Phthalate NOAEL Studies
INCI: DIMETHYL PHTHALATE
CAS: 131-11-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2860 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2167; row=5598; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl phthalate; preferred_name=Dimethyl phthalate; dtxsid=DTXSID3022455; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022455; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3022455; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2168; row=5599; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl phthalate; preferred_name=Dimethyl phthalate; dtxsid=DTXSID3022455; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022455; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3022455; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 22.26 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1213; Record_ID=adme_parameters_107; Data_Type=Measured; DTXSID=DTXSID3022455; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=22.26; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022455; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022455 |
| NTP ICE adme parameters | Fu | 0.656 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1212; Record_ID=adme_parameters_107; Data_Type=Measured; DTXSID=DTXSID3022455; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.656; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022455; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022455 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=8272; RecordID=ARPathway2016_774; DatasetName=ARPathway2016; DTXSID=DTXSID3022455; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022455; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022455 |
SCCS Opinion 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.000009 | mg/kg/d | dog | oral | - | dermal absorption | p.12 |
| SCCS Opinion | NOAEL | =0.00036 | mg/kg/d | rat | oral | - | dermal absorption | p.11 |
| SCCS Opinion | NOAEL | =0.00163 | mg/kg/d | rat | dermal | developmental | developmental toxicity | p.15 |
| SCCS Opinion | NOAEL | =0.00247 | mg/kg/d | human | dermal | 2005d | dermal absorption | p.14 |
| SCCS Opinion | NOAEL | =0.006 | % | dog | oral | - | dermal absorption | p.12 |
| SCCS Opinion | NOAEL | =0.0167 | % | rat | dermal | - | dermal absorption | p.14 |
| SCCS Opinion | NOAEL | =0.0445 | mg/kg | rat | dermal | - | dermal absorption | p.9 |
| SCCS Opinion | NOAEL | =0.24 | % | rat | oral | - | dermal absorption | p.11 |
| SCCS Opinion | NOAEL | =0.5 | mg/kg/d | rat | - | developmental | developmental toxicity | p.15 |
| SCCS Opinion | NOAEL | =2 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.14 |
| SCCS Opinion | NOAEL | =3 | mg/kg | - | - | 90-day | NOAEL study | p.10 |
| SCCS Opinion | NOAEL | =4.8 | mg/kg/d | rat | dermal | 2005d | dermal absorption | p.14 |
| SCCS Opinion | NOAEL | =4.8 | - | - | - | developmental | reproductive toxicity | p.12 |
| SCCS Opinion | NOAEL | =5 | % | rat | dermal | - | dermal absorption | p.9 |
| SCCS Opinion | NOAEL | =9 | - | - | - | - | NOAEL study | p.9 |
| SCCS Opinion | NOAEL | =10 | - | - | - | - | NOAEL study | p.10 |
| SCCS Opinion | NOAEL | =12 | - | - | - | - | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =13 | - | - | - | - | reproductive toxicity | p.13 |
| SCCS Opinion | NOAEL | =15 | mg/kg bw/day | rat | - | chronic | carcinogenicity | p.11 |
| SCCS Opinion | NOAEL | =15 | mg/kg bw/d | rat | oral | - | dermal absorption | p.11 |
| SCCS Opinion | NOAEL | =15 | - | dog | oral | 13-week | NOAEL study | p.10 |
| SCCS Opinion | NOAEL | =25 | mg/kg/d | rat | oral | 13-week | NOAEL study | p.11 |
| SCCS Opinion | NOAEL | =33 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.11 |
| SCCS Opinion | NOAEL | =50 | mg/kg | rat | oral | developmental | reproductive toxicity | p.10 |
| SCCS Opinion | NOAEL | =50 | mg/kg/d | rat | dermal | developmental | developmental toxicity | p.15 |
| SCCS Opinion | NOAEL | =50 | - | - | - | - | NOAEL study | p.9 |
| SCCS Opinion | NOAEL | =100 | ppm | - | - | developmental | reproductive toxicity | p.12 |
| SCCS Opinion | NOAEL | =201 | - | - | - | - | reproductive toxicity | p.13 |
| SCCS Opinion | NOAEL | =600 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.9 |
| SCCS Opinion | NOAEL | =600 | - | - | - | - | NOAEL study | p.9 |
| SCCS Opinion | NOAEL | =1016 | - | - | - | - | reproductive toxicity | p.13 |
| SCCS Opinion | NOAEL | =2982 | mg/kg | - | - | - | NOAEL study | p.9 |
EPA ToxRefDB v3 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =3570 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 15 GD | DEV | study_id=2071; toxval_study_source_id=studyid2071_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-liver-relative to body weight|in life observation-food consumption-food consumption|in life observation-water consumption-water consumption|organ weight-kidney-relative to body weight; dose_level=3; study_year=1989; study_citation=Developmental Toxicity Evaluation of Dimethyl Phthalate (CAS 131-11-3) Administered to CD Rats on Gestational Days 6-15 (1989). NTP Study Report: TER88066.; dsstox_substance_id=DTXSID3022455; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =840 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 15 GD | DEV | study_id=2071; toxval_study_source_id=studyid2071_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|organ weight-liver-relative to body weight|in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|organ weight-kidney-relative to body weight; dose_level=2; study_year=1989; study_citation=Developmental Toxicity Evaluation of Dimethyl Phthalate (CAS 131-11-3) Administered to CD Rats on Gestational Days 6-15 (1989). NTP Study Report: TER88066.; dsstox_substance_id=DTXSID3022455; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB Alaska DEC 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =9 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445854:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=4ece426b7fee89bf4cdce3733157c544 |
| ToxValDB Alaska DEC | RfD | =10 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445855:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=52b743064179e37201325dec922b423b |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =71479.9 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15514876:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41998b0a8841910dadbee070df4723b2 |
ToxValDB ECOTOX 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEC | =15 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3c7532fdc52dd66afd79452ef292c2ae |
| ToxValDB ECOTOX | NOEC | =300 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1a2e0cc91be026646165215af1e04fd9 |
| ToxValDB ECOTOX | NOEC | >365 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fcd89ca1c869021e6604d703685498c0 |
| ToxValDB ECOTOX | NOEC | >375 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5f3fbecc9b8c4009c6e83ca36226f4ce |
| ToxValDB ECOTOX | NOEC | >400 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7206c9db20cc08ef5f6044582f91700f |
| ToxValDB ECOTOX | NOEC | >750 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600854_15605544_15610715_15610730_15610750_15610780:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f7e450fa018244dd4cc743ac0008f9d4 |
| ToxValDB ECOTOX | NOEL | =2 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.53(1): 35-41 Oishi,S., and K. Hiraga Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations 1980; TITLE=Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations; AUTHOR=Oishi,S., and K. Hiraga; DOI=10.1016/0041-008x(80)90378-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=66065; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content|Growth: Weight|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598851_15608311:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0118efe192a863a52cef528e8f4f5689 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =66.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631458:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2acf714a9eb1e2272cedde3f2ac18da2 |
ToxValDB HPVIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =840 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Field et al., (1993). Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology 38:33-44.; QUALITY=1; EXTERNAL_SOURCE_ID=59024; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642642:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12f0c03c14bb8a90706810b9a69a99ea |
| ToxValDB HPVIS | NOAEL | >3570 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Field et al., (1993). Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology 38:33-44.; QUALITY=1; EXTERNAL_SOURCE_ID=59429; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642749:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a35abdfeb847e7483f7b5fa22d69b786 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | LOAEL | =302 | mg/kg bw/day | Rat | oral | short-term; 1 weeks | short-term | LONG_REF=Oishi, S. and K. Hiraga. 1980. Testicular atrophy induced by phthalic acid esters: effect on testosterone and zinc concentrations. Toxicol. Appl. Pharmacol. 53:35-41.; AUTHOR=Oishi, S. and K. Hiraga; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1716; TOXICOLOGICAL_EFFECT=increased absolute and relative liver weight and decreased serum and testicular testosterone; STUDY_GROUP=PPRTV (CPHEA):15654083:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c8c03f715eaacee8e24a97fb67fcb2a7 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Oishi, S. and K. Hiraga. 1980. Testicular atrophy induced by phthalic acid esters: effect on testosterone and zinc concentrations. Toxicol. Appl. Pharmacol. 53:35-41.; AUTHOR=Oishi, S. and K. Hiraga; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1716; TOXICOLOGICAL_EFFECT=increased absolute and relative liver weight and decreased serum and testicular testosterone in male rats; STUDY_GROUP=PPRTV (CPHEA):15653639:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa65e7742c611979224006eeef763583 |
ToxValDB ToxRefDB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =3570 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Developmental Toxicity Evaluation of Dimethyl Phthalate (CAS 131-11-3) Administered to CD Rats on Gestational Days 6-15 (1989). NTP Study Report: TER88066.; TITLE=Developmental Toxicity Evaluation of Dimethyl Phthalate (CAS 131-11-3) Administered to CD Rats on Gestational Days 6-15; AUTHOR=NTP; EXTERNAL_SOURCE_ID=2071; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: in life observation-food consumption-food consumption|systemic: in life observation-water consumption-water consumption|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15691882_15691883_15691884_15691885:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_68aabf062ad36aef4aae4268cc94b44f |
Regulatory source 42 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 3 | mg/kg | - | - | 90-day | - | p.10 |
| Regulatory source | - | 5 | % | rat | - | - | - | p.10 |
| Regulatory source | - | 9 | - | - | - | - | - | p.9 |
| Regulatory source | - | 10 | - | - | - | - | - | p.10 |
| Regulatory source | - | 12 | - | - | - | - | - | p.12 |
| Regulatory source | - | 13 | - | - | - | - | - | p.13 |
| Regulatory source | - | 15 | mg/kg bw/day | rat | oral | 13-week | - | p.11 |
| Regulatory source | - | 15 | mg/kg bw/day | rat | - | 2-year | - | p.11 |
| Regulatory source | - | 15 | - | dog | oral | 13-week | - | p.10 |
| Regulatory source | - | 25 | mg/kg/d | rat | oral | 13-week | - | p.11 |
| Regulatory source | - | 33 | mg/kg bw/day | rat | oral | 13-week | - | p.11 |
| Regulatory source | - | 50 | - | - | - | - | - | p.9 |
| Regulatory source | - | 600 | - | - | - | - | - | p.9 |
| Regulatory source | - | 2982 | mg/kg | - | - | - | - | p.9 |
| Regulatory source | carcinogenicity | 15 | mg/kg bw/day | rat | - | chronic | carcinogenicity | p.11 |
| Regulatory source | carcinogenicity | 15 | mg/kg bw/day | rat | dermal | chronic | carcinogenicity | p.11 |
| Regulatory source | dermal absorption | =0.000009 | mg/kg/d | dog | oral | - | dermal absorption | p.12 |
| Regulatory source | dermal absorption | =0.00036 | mg/kg/d | rat | oral | - | dermal absorption | p.11 |
| Regulatory source | dermal absorption | =0.00247 | mg/kg/d | human | dermal | 2005d | dermal absorption | p.14 |
| Regulatory source | dermal absorption | 0.006 | % | dog | oral | - | dermal absorption | p.12 |
| Regulatory source | dermal absorption | 0.0167 | % | rat | dermal | - | dermal absorption | p.14 |
| Regulatory source | dermal absorption | =0.0445 | mg/kg | rat | dermal | - | dermal absorption | p.9 |
| Regulatory source | dermal absorption | 0.24 | % | rat | oral | - | dermal absorption | p.11 |
| Regulatory source | dermal absorption | 4.8 | mg/kg/d | rat | dermal | 2005d | dermal absorption | p.14 |
| Regulatory source | dermal absorption | 5 | % | rat | dermal | - | dermal absorption | p.9 |
| Regulatory source | dermal absorption | 5 | % | rat | dermal | 2005d | dermal absorption | p.14 |
| Regulatory source | dermal absorption | =15 | mg/kg bw/d | rat | oral | - | dermal absorption | p.11 |
| Regulatory source | dermal absorption | =15 | mg/kg bw/d | dog | oral | - | dermal absorption | p.12 |
| Regulatory source | dermal absorption | 600 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.9 |
| Regulatory source | developmental toxicity | =0.00163 | mg/kg/d | rat | dermal | developmental | developmental toxicity | p.15 |
| Regulatory source | developmental toxicity | 0.5 | mg/kg/d | rat | - | developmental | developmental toxicity | p.15 |
| Regulatory source | developmental toxicity | 5 | % | rat | oral | developmental | developmental toxicity | p.14 |
| Regulatory source | developmental toxicity | 50 | mg/kg/d | rat | dermal | developmental | developmental toxicity | p.15 |
| Regulatory source | reproductive toxicity | 2 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.14 |
| Regulatory source | reproductive toxicity | 4.8 | - | - | - | developmental | reproductive toxicity | p.12 |
| Regulatory source | reproductive toxicity | 5 | % | rat | oral | 13-week | reproductive toxicity | p.10 |
| Regulatory source | reproductive toxicity | 13 | - | - | - | - | reproductive toxicity | p.13 |
| Regulatory source | reproductive toxicity | 50 | mg/kg | rat | oral | developmental | reproductive toxicity | p.10 |
| Regulatory source | reproductive toxicity | 50 | - | - | - | - | reproductive toxicity | p.13 |
| Regulatory source | reproductive toxicity | 100 | ppm | - | - | developmental | reproductive toxicity | p.12 |
| Regulatory source | reproductive toxicity | 201 | - | - | - | - | reproductive toxicity | p.13 |
| Regulatory source | reproductive toxicity | 1016 | - | - | - | - | reproductive toxicity | p.13 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 08X7F5UDJM | UNII | - | - | - | chemical | - |