Name: Dimethyl Stearamine NOAEL Studies
Creator: Roots by Benda

CIR_vision_codex 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
CIR_vision_codex	NOAEL	=50	mg/kg bw	rat	oral	14 days	developmental toxicity	{"citation":"300; 3; 5","dose":"In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study.","effect":"e group. In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study. No other information is provided about effects observed in the highest dose group. Animals in the 150 mg/kg bw group were observed rubbing their snouts in the bedding material after dosing for approximately 5 minutes. This was not observed in the 50 mg/kg bw group. No mention is made regarding this behavior in the 300 mg/kg bw group. The authors concluded that 50 mg/kg bw is an oral NOEL based on this study.12 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS Dimethyl Lauramine Sprague-Dawley rats (10/sex/group) were treated by gavage with dimethyl lauramine at dose levels of 0, 50, 150, 300 and 450 mg/kg bw/day.12 Males were treated 14 days prior to mating and during the 14-day mating period and females were treated 14 days prior to mating and throughout the mating, pregnancy and lactation periods. The highest dose group was discontinued due to the deaths of 3 animals (1 male and 2 females) on day 4 of the test and the poor health exhibited by the remaining a...","page":8,"pdf":"FR553.pdf","row_type":"noael_study","study_id":"FR553_noael_001"}
CIR_vision_codex	NOAEL	=50	mg/kg bw	rat	oral	14 days	developmental toxicity	{"citation":"300; 3; 5","dose":"In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study.","effect":"e group. In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study. No other information is provided about effects observed in the highest dose group. Animals in the 150 mg/kg bw group were observed rubbing their snouts in the bedding material after dosing for approximately 5 minutes. This was not observed in the 50 mg/kg bw group. No mention is made regarding this behavior in the 300 mg/kg bw group. The authors concluded that 50 mg/kg bw is an oral NOEL based on this study.12 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS Dimethyl Lauramine Sprague-Dawley rats (10/sex/group) were treated by gavage with dimethyl lauramine at dose levels of 0, 50, 150, 300 and 450 mg/kg bw/day.12 Males were treated 14 days prior to mating and during the 14-day mating period and females were treated 14 days prior to mating and throughout the mating, pregnancy and lactation periods. The highest dose group was discontinued due to the deaths of 3 animals (1 male and 2 females) on day 4 of the test and the poor health exhibited by the remaining a...","page":8,"pdf":"FR553.pdf","row_type":"noael_study","study_id":"FR553_noael_001"}
CIR_vision_codex	NOAEL	=50	mg/kg bw	rat	oral	14 days	developmental toxicity	{"citation":"300; 3; 5","dose":"In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study.","effect":"e group. In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study. No other information is provided about effects observed in the highest dose group. Animals in the 150 mg/kg bw group were observed rubbing their snouts in the bedding material after dosing for approximately 5 minutes. This was not observed in the 50 mg/kg bw group. No mention is made regarding this behavior in the 300 mg/kg bw group. The authors concluded that 50 mg/kg bw is an oral NOEL based on this study.12 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS Dimethyl Lauramine Sprague-Dawley rats (10/sex/group) were treated by gavage with dimethyl lauramine at dose levels of 0, 50, 150, 300 and 450 mg/kg bw/day.12 Males were treated 14 days prior to mating and during the 14-day mating period and females were treated 14 days prior to mating and throughout the mating, pregnancy and lactation periods. The highest dose group was discontinued due to the deaths of 3 animals (1 male and 2 females) on day 4 of the test and the poor health exhibited by the remaining a...","page":8,"pdf":"FR553.pdf","row_type":"noael_study","study_id":"FR553_noael_001"}
CIR_vision_codex	NOAEL	=50	mg/kg bw	rat	oral	14 days	developmental toxicity	{"citation":"300; 3; 5","dose":"In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study.","effect":"e group. In the 300 mg/kg bw group, 3 of the 5 females died during the study while all of the males survived to the end of the study. No other information is provided about effects observed in the highest dose group. Animals in the 150 mg/kg bw group were observed rubbing their snouts in the bedding material after dosing for approximately 5 minutes. This was not observed in the 50 mg/kg bw group. No mention is made regarding this behavior in the 300 mg/kg bw group. The authors concluded that 50 mg/kg bw is an oral NOEL based on this study.12 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS Dimethyl Lauramine Sprague-Dawley rats (10/sex/group) were treated by gavage with dimethyl lauramine at dose levels of 0, 50, 150, 300 and 450 mg/kg bw/day.12 Males were treated 14 days prior to mating and during the 14-day mating period and females were treated 14 days prior to mating and throughout the mating, pregnancy and lactation periods. The highest dose group was discontinued due to the deaths of 3 animals (1 male and 2 females) on day 4 of the test and the poor health exhibited by the remaining a...","page":8,"pdf":"FR553.pdf","row_type":"noael_study","study_id":"FR553_noael_001"}

NTP_ICE_acute_oral 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_oral	LD50	=2116	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	OECD eChemPortal (undated); record_id=acute_oral_1912; row=7366; data_type=In Vivo; mixture=Chemical; chemical_name=N,N-Dimethyl-1-octadecanamine; preferred_name=N,N-Dimethyl-1-octadecanamine; dtxsid=DTXSID4027026; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027026; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=2118	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	OECD eChemPortal (undated); record_id=acute_oral_1913; row=7365; data_type=In Vivo; mixture=Chemical; chemical_name=N,N-Dimethyl-1-octadecanamine; preferred_name=N,N-Dimethyl-1-octadecanamine; dtxsid=DTXSID4027026; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027026; source_file=acute_oral.xlsx

ToxValDB_GESTIS_DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_GESTIS_DNEL	DNEL local	=1	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631301_15631302:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0622856bedacfdba346968c1c8cf1ac

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	066975NG22	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C20H43N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"066975NG22"}
openFDA substances	FDA UNII substance identifier	066975NG22	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C20H43N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"066975NG22"}
openFDA substances	FDA UNII substance identifier	066975NG22	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C20H43N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"066975NG22"}
openFDA substances	FDA UNII substance identifier	066975NG22	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C20H43N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"066975NG22"}