Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Succinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >1000 mg/kg bw/day | dermal | rat | dermal | REACH |
Expert Verdict
CIR has this ingredient listed in draft report stage with final opinion pending; ensure dibasic ester grade is cosmetic-appropriate as eye irritation is possible at high concentrations
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Succinate safe in cosmetics?
CIR has this ingredient listed in draft report stage with final opinion pending; ensure dibasic ester grade is cosmetic-appropriate as eye irritation is possible at high concentrations The EU classifies Dimethyl Succinate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Dimethyl Succinate allowed in the EU?
Dimethyl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Succinate do in cosmetics?
Dimethyl Succinate functions as: Solvent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 106-65-0.
What is the Margin of Safety for Dimethyl Succinate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Succinate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Succinate is >1000 mg/kg bw/day based on a dermal study via dermal route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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