Dipalmitoyl Glutathione

INCI: DIPALMITOYL GLUTATHIONE

CAS Number
37491-53-5
Function
Hair conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction; not specifically CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Very limited published toxicological data; no CIR monograph; no SCCS opinion; glutathione backbone is endogenous (favorable), but palmitoylated form lacks standalone safety studies; recommend read-across from amino acid alkyl amides CIR report (2017) and HRIPT.

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Concern Level: Moderate

Frequently Asked Questions

Is Dipalmitoyl Glutathione safe in cosmetics?

Very limited published toxicological data; no CIR monograph; no SCCS opinion; glutathione backbone is endogenous (favorable), but palmitoylated form lacks standalone safety studies; recommend read-across from amino acid alkyl amides CIR report (2017) and HRIPT. The EU classifies Dipalmitoyl Glutathione as "permitted". Safety rating: MODERATE.

Is Dipalmitoyl Glutathione allowed in the EU?

Dipalmitoyl Glutathione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipalmitoyl Glutathione do in cosmetics?

Dipalmitoyl Glutathione functions as: Hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 37491-53-5.

What is the Margin of Safety for Dipalmitoyl Glutathione?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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