Poor Cosmetic Ingredient NOAEL Data

Dipropylenetriamine ⚠️

INCI: DIPROPYLENETRIAMINE

CAS Number
56-18-8
Function
Industrial curing agent, epoxy hardener, chemical intermediate
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes No cosmetic listing; classified as hazardous under OSHA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Dipropylenetriamine ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 15 mg/kg bw/day oral rat oral REACH
NOAEL ca.20 mg/kg bw/day oral rat oral REACH

Expert Verdict

Classified as hazardous with H302, H311, H314, H317, H330, H341, and H373 hazard statements; potential for nitrosamine formation. Not approved for cosmetic use.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dipropylenetriamine ⚠️ safe in cosmetics?

Classified as hazardous with H302, H311, H314, H317, H330, H341, and H373 hazard statements; potential for nitrosamine formation. Not approved for cosmetic use. The EU classifies Dipropylenetriamine ⚠️ as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is Dipropylenetriamine ⚠️ allowed in the EU?

Dipropylenetriamine ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipropylenetriamine ⚠️ do in cosmetics?

Dipropylenetriamine ⚠️ functions as: Industrial curing agent, epoxy hardener, chemical intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 56-18-8.

What is the Margin of Safety for Dipropylenetriamine ⚠️?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dipropylenetriamine ⚠️?

The NOAEL (No Observed Adverse Effect Level) for Dipropylenetriamine ⚠️ is 15 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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