Disodium Phloretin Disulfonate

INCI: DISODIUM PHLORETIN DISULFONATE

CAS Number
Related to GSRS entry; MW 478.36, molecular formula C₁₅H₁₂O₁₁S₂·2Na
Function
Antioxidant; skin-conditioning agent (water-soluble sulfonated derivative of phloretin, a flavonoid from apple bark)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Parent phloretin is GRAS as food component; sulfonated form expected to have improved safety profile due to reduced penetration; verify supplier purity specification for residual solvents from sulfonation process

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Concern Level: Low

Frequently Asked Questions

Is Disodium Phloretin Disulfonate safe in cosmetics?

Parent phloretin is GRAS as food component; sulfonated form expected to have improved safety profile due to reduced penetration; verify supplier purity specification for residual solvents from sulfonation process The EU classifies Disodium Phloretin Disulfonate as "permitted". Safety rating: GOOD.

Is Disodium Phloretin Disulfonate allowed in the EU?

Disodium Phloretin Disulfonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Phloretin Disulfonate do in cosmetics?

Disodium Phloretin Disulfonate functions as: Antioxidant; skin-conditioning agent (water-soluble sulfonated derivative of phloretin, a flavonoid from apple bark). It is classified as a cosmetic ingredient in our database. CAS number: Related to GSRS entry; MW 478.36, molecular formula C₁₅H₁₂O₁₁S₂·2Na.

What is the Margin of Safety for Disodium Phloretin Disulfonate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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