NOAEL Studies Cosmetic Ingredient

Disperse Red 17 NOAEL Studies

INCI: DISPERSE RED 17

CAS: 3179-89-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 90 day Subchronic SCCP; Fabreguettes, C.; 13-week toxicity study by oral administration (gavage) in rats;CENTRE INTERNATIONAL DE TOXICOLOGIE
SCCNFP Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =10 mg/kg bw/day rat - - irritation p.9
SCCNFP Opinion NOAEL =30 mg/kg bw/day rat - - irritation p.9
SCCNFP Opinion NOAEL =41.2 % rat - 13 weeks NOAEL study p.8
SCCNFP Opinion NOAEL =125 mg/kg bw/day human - - developmental toxicity Ref. : 11 2, p.12
SCCS Opinion 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =41.2 % rat oral 13 weeks NOAEL study p.17
SCCS Opinion NOAEL =30 mg/kg bw/day rat - Chronic genotoxicity p.18
SCCS Opinion NOAEL =10 mg/kg bw/day rat - Chronic genotoxicity p.18
SCCS Opinion NOAEL =125 mg/kg bw/day human - - developmental toxicity p.25
SCCS Opinion NOAEL =0.0075 mg/kg rat dermal - dermal absorption p.26
SCCS Opinion NOAEL =1.55 mg/kg bw/day rat dermal - dermal absorption p.26
SCCS Opinion NOAEL =31 % rat dermal - dermal absorption p.26
SCCS Opinion NOAEL =0.0055 mg/kg rat dermal - dermal absorption p.26
SCCS Opinion NOAEL =4 mg/kg bw rat - subchronic repeated dose toxicity p.27
SCCS Opinion NOAEL =3.1 mg/kg bw/day rabbit - developmental developmental toxicity p.27
SCCS Opinion NOAEL =10 mg/kg bw/day rat - Chronic NOAEL study p.17
SCCS Opinion NOAEL =30 mg/kg bw/day rat - Chronic NOAEL study p.17
SCCS Opinion NOAEL =41.2 % rat - 13 weeks NOAEL study p.16
Regulatory source 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 10 mg/kg bw/day rat oral 13 week - p.17
Regulatory source - 41.2 % rat - 13 weeks - p.8
Regulatory source developmental toxicity 125 mg/kg bw/day human - - developmental toxicity p.12
Regulatory source irritation 10 mg/kg bw/day rat - - irritation p.9
Regulatory source irritation 30 mg/kg bw/day rat - - irritation p.9
Regulatory source - 41.2 % rat oral 13 weeks - p.17
Regulatory source - 10 mg/kg bw/day rat - Chronic - p.17
Regulatory source - 30 mg/kg bw/day rat - Chronic - p.17
Regulatory source dermal absorption =0.0075 mg/kg rat dermal - dermal absorption p.26
Regulatory source dermal absorption =1.55 mg/kg bw/day rat dermal - dermal absorption p.26
Regulatory source dermal absorption 31 % rat dermal - dermal absorption p.26
Regulatory source dermal absorption =0.0055 mg/kg rat dermal - dermal absorption p.26
Regulatory source developmental toxicity 30 mg/kg bw/day rat - developmental developmental toxicity p.24
Regulatory source developmental toxicity 3.1 mg/kg bw/day rabbit - developmental developmental toxicity p.27
Regulatory source genotoxicity 30 mg/kg bw/day rat - Chronic genotoxicity p.18
Regulatory source genotoxicity 10 mg/kg bw/day rat - Chronic genotoxicity p.18
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat - subchronic repeated dose toxicity p.27
Regulatory source repeated dose toxicity 4 mg/kg bw rat - subchronic repeated dose toxicity p.27
Regulatory source repeated dose toxicity 30 mg/kg bw/day rat - subchronic repeated dose toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HHG9JOS5G7 UNII - - - chemical -