Is Disperse Red 17 safe in cosmetics?
Disperse Red 17 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Disperse Red 17
Also known as: Ethanol, 2,2'-[[3-methyl-4-[2-(4-nitrophenyl)diazenyl]phenyl]imino]bis-, Ethanol, 2,2'-[4-(p-nitrophenylazo)-m-tolylimino]di-, Ethanol, 2,2'-[[3-methyl-4-[(4-nitrophenyl)azo]phenyl]imino]bis-, 2,2'-[[3-Methyl-4-[2-(4-nitrophenyl)diazenyl]phenyl]imino]bis[ethanol], 3-Methyl-4-(4'-nitrophenylazo)-N,N-bis(2-hydroxyethyl)aniline (+14 more)
INCI: DISPERSE RED 17
Disperse Red 17 (CAS 3179-89-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing (azo dye); semi-permanent and oxidative formulations. NOAEL 1.55 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3179-89-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Disperse Red 17 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H317, H302, H373, H411).
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Hair dyeing (azo dye); semi-permanent and oxidative formulations
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[N-(2-hydroxyethyl)-3-methyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol
InChIKey
ADCWDMYESTYBBN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.2%
US US Status
permitted
US Notes
Not specifically listed under 21 CFR 73/74/82; coal tar hair dye exemption applies with caution labeling
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disperse Red 17.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Disperse Red 17. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =10 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =10 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =10 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =30 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =30 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =30 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =30 mg/kg bw/day | - | rat | irritation | SCCNFP Opinion |
| NOAEL | =125 mg/kg bw/day | - | human | developmental toxicity | SCCNFP Opinion |
| NOAEL | =125 mg/kg bw/day | - | human | developmental toxicity | SCCNFP Opinion |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disperse Red 17 across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1
Hazard Statements
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP21
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a)Hair dye substance in oxidative hair dye products (b)Hair dye substance in non-oxidative hair dye products. Max: (b) 0,2 %.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0,2 %
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (4 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.89% | - | - | SCCP/0156 |
| default | 0.11% | - | - | SCCP/0156 |
| measured | 0.89% | - | - | SCCS/0143 |
| default | 0.11% | - | - | SCCS/0143 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "3179-89-3", "ingredient_class": "direct_dye", "color_index_CI_number": "11210", "chemical_class": "azo", "color_result_on_hair": "Red", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "good", "oxidation_mechanism": "direct_absorption", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Disperse Red 17.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Disperse Red 17 by CAS number or substance name.
Studies
60
Lowest NOAEL
0.0055
Highest NOAEL
125
Units vary across source rows: mg/kg, mg/kg bw/day, mg/kg bw
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.89% | - | - |
| 0.11% | - | - |
| 0.89% | - | - |
| 0.11% | - | - |
Known Synonyms
Ethanol, 2,2'-[[3-methyl-4-[2-(4-nitrophenyl)diazenyl]phenyl]imino]bis-
Ethanol, 2,2'-[4-(p-nitrophenylazo)-m-tolylimino]di-
Ethanol, 2,2'-[[3-methyl-4-[(4-nitrophenyl)azo]phenyl]imino]bis-
2,2'-[[3-Methyl-4-[2-(4-nitrophenyl)diazenyl]phenyl]imino]bis[ethanol]
3-Methyl-4-(4'-nitrophenylazo)-N,N-bis(2-hydroxyethyl)aniline
4-Nitro-4'-[bis(2-hydroxyethyl)amino]-2'-methylazobenzene
4-[Bis(2-hydroxyethyl)amino]-2-methyl-4'-nitroazobenzene
Acetamine Red BE
Disperse Red R
Diacelliton Fast Red R
Diacelliton Red R-M/D
Diacelliton Red RF
Eastone Red R
Fenacet Fast Red 2G
C.I. 11210
2,2'-[[3-methyl-4-[(4-nitrophenyl)azo]phenyl]imino]bisethanol
C.I. disperse red 017
C.I. DISPERSE RED 17
EC No.: 221-665-5
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Disperse Red 17 allowed in the EU?
Disperse Red 17 EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Disperse Red 17 do in cosmetics?
Disperse Red 17 functions as: Hair dyeing (azo dye); semi-permanent and oxidative formulations. It is classified as a cosmetic ingredient in our database. CAS number: 3179-89-3.
What is the NOAEL for Disperse Red 17?
The NOAEL (No Observed Adverse Effect Level) for Disperse Red 17 is =10 mg/kg bw/day based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is Disperse Red 17 used outside cosmetics?
Disperse Red 17 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Disperse Red 17 have different safety status in cosmetics vs industrial chemicals?
Disperse Red 17 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H317, H302, H373, H411).
Compliance Tools
Check Disperse Red 17 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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