NOAEL Studies Cosmetic Ingredient

Disperse Violet 1 NOAEL Studies

INCI: DISPERSE VIOLET 1

CAS: 128-95-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment DERMAL_ABSORPTION =3 % Not stated (anesthetized animals) dermal 10% solution Cutaneous absorption study; thick layer of 10% solution applied to shaved area of abdomen for 3 h 20, p.5
COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 2 mg/kg bw/day rat oral 90 day Subchronic SCCS; van Otterdijk, F. M. 90-day oral toxicity study with Disperse Violet 1/18588/ bydaily gavage in the rat; NOTOX, the Netherlands. Project 397755, 6 June 2005
COSMOS DB NOAEL 0.25 mg/kg bw/day rat oral 90 day Subchronic SCCS; van Otterdijk, F. M. 90-day oral toxicity study with Disperse Violet 1/18588/ bydaily gavage in the rat; NOTOX, the Netherlands. Project 397755, 6 June 2005
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =5790 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2129; row=4722; data_type=In Vivo; mixture=Chemical; chemical_name=1,4-Diaminoanthraquinone; preferred_name=1,4-Diaminoanthraquinone; dtxsid=DTXSID2041252; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041252; source_file=acute_oral.xlsx
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 8.20890019925237 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=813; RecordID=ARPathway2016_349; DatasetName=ARPathway2016; DTXSID=DTXSID2041252; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=8.20890019925237; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041252
NTP ICE endocrine ACC 62.33937348 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=812; RecordID=ARPathway2016_349; DatasetName=ARPathway2016; DTXSID=DTXSID2041252; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=62.33937348; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041252
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=814; RecordID=ARPathway2016_349; DatasetName=ARPathway2016; DTXSID=DTXSID2041252; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041252
NTP ICE endocrine Model Score 0.0102 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=815; RecordID=ARPathway2016_349; DatasetName=ARPathway2016; DTXSID=DTXSID2041252; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0102; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041252
SCCNFP Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =1.21 mg/kg guinea pig - - irritation Ref. : 15 2, p.7
SCCNFP Opinion NOAEL =1.21 mg/kg/day rat oral sub-chronic repeated dose toxicity p.21
SCCNFP Opinion NOAEL =2 % human dermal - irritation p.21
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.003 mg/kg bw rat oral 90-day dermal absorption Ref.: 31 (Subm, p.25
SCCS Opinion NOAEL =2 mg/kg/day - - Chronic genotoxicity Ref.: 23 (subm, p.16
SCCS Opinion NOAEL =2 mg/kg bw/d rat oral 90-day dermal absorption p.25
SCCS Opinion NOAEL =40 mg/kg bw human - - developmental toxicity Ref.: 28 (Subm, p.23
SCCS Opinion NOAEL =40 mg/kg bw/d rat dermal sub-chronic repeated dose toxicity p.26
SCCS Opinion NOAEL =160 mg/kg bw - - - NOAEL study p.23
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source irritation 1.21 mg/kg guinea pig - - irritation p.7
Regulatory source irritation 2 % human dermal - irritation p.21
Regulatory source repeated dose toxicity 1.21 mg/kg/day rat oral sub-chronic repeated dose toxicity p.21
Regulatory source - 40 mg/kg bw/d - - - - p.26
Regulatory source - 160 mg/kg bw - - - - p.23
Regulatory source dermal absorption =0.003 mg/kg bw rat oral 90-day dermal absorption p.25
Regulatory source dermal absorption =2 mg/kg bw/d rat oral 90-day dermal absorption p.25
Regulatory source developmental toxicity 40 mg/kg bw human - - developmental toxicity p.23
Regulatory source genotoxicity 2 mg/kg/day - - Chronic genotoxicity p.16
Regulatory source repeated dose toxicity 2 mg/kg bw/d rat - sub-chronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity 40 mg/kg bw/d rat dermal sub-chronic repeated dose toxicity p.26
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier N21HDQ0TKN UNII - - - chemical -