Dodecylhexadecyltrimonium Chloride

INCI: DODECYLHEXADECYLTRIMONIUM CHLORIDE

CAS Number
103807-18-7
Function
Antistatic, hair conditioning, surfactant-cleansing, surfactant-emulsifying
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not individually restricted under 21 CFR; CIR reviewed trimoniums as safe with concentration caveats

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Primary concern is irritation, not sensitization. Concentration-dependent ocular and dermal irritant. Must comply with EU Annex III quat limits for leave-on products. Rinse-off use at typical levels (โ‰ค2%) generally acceptable. CIR panel concluded trimoniums safe as used when formulated to be non-irritating.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dodecylhexadecyltrimonium Chloride safe in cosmetics?

Primary concern is irritation, not sensitization. Concentration-dependent ocular and dermal irritant. Must comply with EU Annex III quat limits for leave-on products. Rinse-off use at typical levels (โ‰ค2%) generally acceptable. CIR panel concluded trimoniums safe as used when formulated to be non-irritating. The EU classifies Dodecylhexadecyltrimonium Chloride as "restricted". Safety rating: MODERATE.

Is Dodecylhexadecyltrimonium Chloride allowed in the EU?

Dodecylhexadecyltrimonium Chloride EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dodecylhexadecyltrimonium Chloride do in cosmetics?

Dodecylhexadecyltrimonium Chloride functions as: Antistatic, hair conditioning, surfactant-cleansing, surfactant-emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 103807-18-7.

What is the Margin of Safety for Dodecylhexadecyltrimonium Chloride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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