Good Cosmetic Ingredient NOAEL Data

Erythorbic Acid

INCI: ERYTHORBIC ACID

CAS Number
89-65-6
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes GRAS as food preservative under 21 CFR 182.3041; CIR reaffirmed safe as used in 2022; leave-on ≤0.1%, rinse-off ≤0.7%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Erythorbic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 7500 mg/kg bw/day oral dog Chronic COSMOS_DB
dose_tested 5000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Chronic COSMOS_DB
dose_tested 1000 mg/kg bw/day oral dog Chronic COSMOS_DB
dose_tested 7500 mg/kg bw/day oral dog Chronic COSMOS_DB

Expert Verdict

Safe as used per CIR 2022 re-review; overwhelmingly used in oxidative hair dyes at 0.2-0.7%; poor skin penetration favorable for formulation-stabilizing antioxidant; no EU Annex restrictions.

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Concern Level: Low

Regulatory Flags

antioxidant synthetic hair-dye-use gras-food cir-reviewed d-stereoisomer fermentation-derived fda_food_additive jecfa_safe

Frequently Asked Questions

Is Erythorbic Acid safe in cosmetics?

Safe as used per CIR 2022 re-review; overwhelmingly used in oxidative hair dyes at 0.2-0.7%; poor skin penetration favorable for formulation-stabilizing antioxidant; no EU Annex restrictions. The EU classifies Erythorbic Acid as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Erythorbic Acid allowed in the EU?

Erythorbic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Erythorbic Acid do in cosmetics?

Erythorbic Acid functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 89-65-6.

What is the Margin of Safety for Erythorbic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Erythorbic Acid?

The NOAEL (No Observed Adverse Effect Level) for Erythorbic Acid is 5000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Erythorbic Acid compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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