Escin

INCI: ESCIN

CAS Number
6805-41-0
Function
Anti-inflammatory, Skin Conditioning, Antioxidant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No GRAS classification; no OTC monograph status; no standalone CIR final report for isolated escin

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Permitted under EU cosmetic safety framework with REACH registration completed; beta-aescin haemolytic activity in vitro not considered clinically significant for topical use; margin of safety must be calculated by safety assessor.

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Concern Level: Moderate

Regulatory Flags

saponin triterpenoid anti-cellulite venotonic horse-chestnut no-sccs-opinion no-cir-review reach-registered haemolytic-in-vitro

Frequently Asked Questions

Is Escin safe in cosmetics?

Permitted under EU cosmetic safety framework with REACH registration completed; beta-aescin haemolytic activity in vitro not considered clinically significant for topical use; margin of safety must be calculated by safety assessor. The EU classifies Escin as "permitted". Safety rating: MODERATE.

Is Escin allowed in the EU?

Escin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Escin do in cosmetics?

Escin functions as: Anti-inflammatory, Skin Conditioning, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 6805-41-0.

What is the Margin of Safety for Escin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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