NOAEL Studies
Cosmetic Ingredient
Ethoxydiglycol NOAEL Studies
INCI: ETHOXYDIGLYCOL
CAS: 111-90-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =0.5 | - | rat | oral (dietary) | 90 days | NOAEL study | p.12 |
| CIR Safety Assessment | NOAEL | =0.6 | - | mouse | oral (dietary) | 90 days | NOAEL study | p.12 |
| CIR Safety Assessment | NOAEL | =167 | - | pig | oral | 90 days | NOAEL study | p.12 |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOEL | ~250 | mg/kg bw/day | Rat; Mouse; Pig | - | - | Toxicology study | document_id=kemi_kemi_ah1997_25; title=Scientific Basis for Swedish Occupational Standards XVIII; path=mirror/documents/kemi/kemi/ah1997_25.pdf; row_hash=c2a77f1e0eeada19; raw_unit=mg/kg/day; context=The NOEL was reported to be 0.5% (equivalent to about 250 mg/kg/day) for rats, 0.6% (850- 4 1000 mg/kg/day) for mice, and 167 mg/kg/day for pigs. |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >5.24 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1422; Record_ID=acute_inhalation_2598; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021941; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.24; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021941 |
NTP ICE acute oral 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | <5 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1082; row=4011; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1920 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1083; row=3998; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1084; row=3999; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5540 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1085; row=4000; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1086; row=4001; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5900 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1087; row=4002; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <6100 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1088; row=4003; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1089; row=4004; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1090; row=4005; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1091; row=4006; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1092; row=4007; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9740 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1093; row=4008; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =10502 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1094; row=4009; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =15918 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1095; row=4010; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Ethoxyethoxy)ethanol; preferred_name=2-(2-Ethoxyethoxy)ethanol; dtxsid=DTXSID2021941; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021941; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1410; RecordID=ARPathway2016_584; DatasetName=ARPathway2016; DTXSID=DTXSID2021941; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021941 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3740; Record_ID=skin_sensitization_invivo_927; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021941; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90067-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021941 |
| NTP ICE skin sensitization | Induction dose per skin area | 12960 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3738; Record_ID=skin_sensitization_invivo_927; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021941; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12960; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90067-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021941 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3744; Record_ID=skin_sensitization_invivo_927; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021941; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90067-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021941 |
SCCS Opinion 69 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.08 | mg/kg bw | human | dermal | - | dermal absorption | p.43 |
| SCCS Opinion | NOAEL | =0.167 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =0.17 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =0.19 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =0.2 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.29 |
| SCCS Opinion | NOAEL | =0.62 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =0.62 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =0.75 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.29 |
| SCCS Opinion | NOAEL | =1 | % | rat | oral | 90 days | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =1 | % | rat | oral | 12 days | repeated dose toxicity | p.22 |
| SCCS Opinion | NOAEL | =1.5 | % | human | dermal | - | dermal absorption | p.43 |
| SCCS Opinion | NOAEL | =1.97 | mg/kg | rat | oral | 2 year | dermal absorption | p.23 |
| SCCS Opinion | NOAEL | =1.97 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.28 |
| SCCS Opinion | NOAEL | =3.16 | mg/kg bw/d | human | oral | - | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =3.35 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =3.52 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =5 | % | rat | oral | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =5 | - | rat | inhalation | 28 day | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =5.4 | % | mouse | oral | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =8.2 | mg/kg bw | dog | dermal | 13 week | dermal absorption | p.43 |
| SCCS Opinion | NOAEL | =10 | % | human | - | - | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =29.5 | % | rat | - | 2 year | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =55.2 | % | rat | oral | 2 year | dermal absorption | p.23 |
| SCCS Opinion | NOAEL | =98.6 | % | rat | inhalation | 5 days | irritation | p.21 |
| SCCS Opinion | NOAEL | =102 | ppm | - | - | - | reproductive toxicity | p.37 |
| SCCS Opinion | NOAEL | =167 | mg/kg bw/d | rabbit | dermal | 13-week | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =167 | mg/kg bw/day | rabbit | dermal | 13- week | NOAEL study | p.27 |
| SCCS Opinion | NOAEL | =167 | mg/kg bw/day | pig | - | 13-week | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =180 | mg/kg bw/d | rat | oral | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =180 | mg/kg bw/day | rat | oral | - | irritation | p.24 |
| SCCS Opinion | NOAEL | =180 | mg/kg | rat | - | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | rat | oral | chronic | genotoxicity | p.19 |
| SCCS Opinion | NOAEL | =200 | mg/kg | rat | oral | 2 year | dermal absorption | p.23 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | rat | oral | 2 year | repeated dose toxicity | p.29 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | rat | oral | 13 weeks | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | 90 day | repeated dose toxicity | p.26 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | 13 weeks | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/d | - | - | - | developmental toxicity | p.21 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | - | - | prenatal | developmental toxicity | p.34 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | rat | - | prenatal | reproductive toxicity | p.35 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | - | - | - | repeated dose toxicity | p.24 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.24 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/d | rat | oral | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | rat | oral | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =800 | mg/kg bw/d | rat | oral | 23 months | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =800 | mg/kg bw/day | rat | oral | 6-week | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =800 | mg/kg bw/day | rat | oral | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =850 | mg/kg bw/d | mouse | oral | 90 days | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =850 | mg/kg bw/day | mouse | oral | 90 days | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw | - | oral | 13 weeks | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =1000 | mg/kg | pig | - | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 30 day | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =1340 | mg/kg bw | rat | oral | 90 days | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =1340 | mg/kg bw/day | rat | - | 6-week | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =1340 | mg/kg bw | rat | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =1340 | mg/kg bw/day | rat | oral | 90 day | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =1500 | mg/kg bw/d | rat | oral | - | NOAEL study | p.18 |
| SCCS Opinion | NOAEL | =1500 | mg/kg bw | - | oral | 13 weeks | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =1500 | mg/kg | dog | - | 90 day | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =2000 | mg/kg bw/d | rat | oral | 63 days | reproductive toxicity | p.21 |
| SCCS Opinion | NOAEL | >2000 | mg/kg bw | - | - | prenatal | developmental toxicity | p.34 |
| SCCS Opinion | NOAEL | >2000 | mg/kg bw | - | - | prenatal | reproductive toxicity | p.35 |
| SCCS Opinion | NOAEL | =2200 | mg/kg bw/d | rat | - | 10 days | reproductive toxicity | p.33 |
| SCCS Opinion | NOAEL | =5360 | mg/kg | rat | - | 6-week | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =29190 | - | rat | oral | - | reproductive toxicity | p.52 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =65853.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15515253:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05f353a7204d637ba261cfcb392a0540 |
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | ~500 | mg/kg bw/day | Pig | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2204d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830622_15830623:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e9dc0d3ae86681c3da356024e2772e0 |
| ECHA | LOAEL | =2000 | mg/kg bw/day | Mouse | oral | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1be4b0a7c65d2204ee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=kidney: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833211_15833212:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2002abd459f255ab56f0572cd28ca98 |
| ECHA | LOAEL | =5500 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bba9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/9/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15824068:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f85de133ccf7cd96f709695f2e2ee284 |
| ECHA | NOAEC | =90 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15828424:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_564defe4bf732aa853224848cab5c219 |
| ECHA | NOAEC | =270 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15828425:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46073b82f770726b2510a19df972fdd1 |
| ECHA | NOAEC | ~527 | mg/kg bw/day | Rat | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f101; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/9/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821553:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_16eae8da225e195013e2b4edbcd3c7b1 |
| ECHA | NOAEL | ~167 | mg/kg bw/day | Pig | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2204d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830622_15830623:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8172eedaa526004fa5c1484af839d5e7 |
| ECHA | NOAEL | =300 | mg/kg bw/day | Rabbit | dermal | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d82e4b096bca8776068; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/4?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826208_15826209:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5608d26a9c74df85d2eec6d674777595 |
| ECHA | NOAEL | <335 | mg/kg bw/day | Mouse | oral | short-term; 8 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1be4b0a7c65d220505; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15835718:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a44262e01c5e30b368d2c5fd36ad8a4e |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbaa2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/9/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15824070:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c75a1d7a9a23cdd5c7fd9bf138442bad |
| ECHA | NOAEL | =1340 | mg/kg bw/day | Rat | oral | subchronic; 6 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c1509; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850422:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c00c2b9c0b663c0575678d9cdd9902ad |
| ECHA | NOAEL | >=2000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b59a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/9/2?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860651_15861352:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ad98d2d98d6420bec583414ec59e077a |
| ECHA | NOAEL | ~5500 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bba9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/9/3?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15824069:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ade4d34324ceceee7b1e194fc773f235 |
| ECHA | NOEL | =100 | mg/kg bw/day | Rabbit | dermal | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d82e4b096bca8776068; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15867/7/6/4?documentUUID=8b80c127-b300-4632-9944-8ce110feda46; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826208_15826209:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff628fc4ce59a748d28183c400415815 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =30 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631183:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a01a7cb0ced94b834e51857d2da4d54 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =0.5 | % | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0debe4b0a676289de6c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1966; ORIGINAL_YEAR=1966; TOXICOLOGICAL_EFFECT=Body Weight Changes: Terminal body weight decrease% |Food Consumption: decrease% |Urinalysis: Oxalate crystals increase% |Hematology: HGB decrease% |Relative Organ Weight: Kidney increase% Spleen increase% Thyroid increase% |Histopathology: Kidney-Advanced intracellular edema% Kidney-Calcification of the renal cortex%; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638179:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8228bca1825bb6a1f6577c0bab58b6c6 |
ToxValDB PPRTV (CPHEA) 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (10 HEC) | =1 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | LONG_REF=Hardy et al. 1997; AUTHOR=Hardy et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1696; TOXICOLOGICAL_EFFECT=irritation; STUDY_GROUP=PPRTV (CPHEA):15653543:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1108b7c2b2eb5a8c5a9a284a0083515 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.0003 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Hardy et al. 1997; AUTHOR=Hardy et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1696; TOXICOLOGICAL_EFFECT=Irritation in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653541_15653542:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4cc36e77bdcb89cfed87094ff87d5d7 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.003 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Hardy et al. 1997; AUTHOR=Hardy et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1696; TOXICOLOGICAL_EFFECT=Irritation in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653541_15653542:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ddc4c414c50814d868cf24a5a783ef8b |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.06 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Gaunt et al. 1968; AUTHOR=Gaunt et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1696; TOXICOLOGICAL_EFFECT=Hydropic degeneration Hydropic degeneration and fatty changes in male/female pigs; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653575_15653730:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fb1a77ac0f2c2d4beecbe5505ba3ef43 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.6 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Gaunt et al. 1968; AUTHOR=Gaunt et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1696; TOXICOLOGICAL_EFFECT=Hydropic degeneration Hydropic degeneration and fatty changes in male/female pigs; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653575_15653730:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6db005070f334ef26769e89aa93e9905 |
Regulatory source 123 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 1 | % | rat | oral | 90 days | - | p.16 |
| Regulatory source | - | 1 | % | rat | - | 4 month | - | p.30 |
| Regulatory source | - | 5 | % | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 5 | - | rat | inhalation | 28 day | - | p.43 |
| Regulatory source | - | 5.4 | % | mouse | oral | 90 day | - | p.29 |
| Regulatory source | - | 10 | % | human | - | - | - | p.43 |
| Regulatory source | - | 29.5 | % | rat | - | 2 year | - | p.29 |
| Regulatory source | - | 102 | ppm | rat | - | - | - | p.48 |
| Regulatory source | - | 167 | mg/kg bw/d | rabbit | dermal | 13-week | - | p.17 |
| Regulatory source | - | 167 | mg/kg bw/day | rabbit | dermal | 13- week | - | p.27 |
| Regulatory source | - | =167 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | =167 | mg/kg bw/day | pig | - | 90 day | - | p.29 |
| Regulatory source | - | 167 | mg/kg bw/day | pig | - | 13-week | - | p.26 |
| Regulatory source | - | 180 | mg/kg bw/d | rat | oral | - | - | p.16 |
| Regulatory source | - | 180 | mg/kg bw/d | rat | oral | 90 days | - | p.26 |
| Regulatory source | - | =180 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 180 | mg/kg | rat | - | 90 day | - | p.29 |
| Regulatory source | - | =180 | mg/kg bw/day | rat | - | 90 day | - | p.29 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 200 | mg/kg bw/day | dog | oral | 13 week | - | p.45 |
| Regulatory source | - | =200 | mg/kg bw/day | rat | - | 2 year | - | p.29 |
| Regulatory source | - | 250 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | =400 | mg/kg bw/day | dog | - | 90 day | - | p.29 |
| Regulatory source | - | 500 | mg/kg bw/d | rat | oral | - | - | p.24 |
| Regulatory source | - | 500 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 800 | mg/kg bw/day | rat | oral | 6-week | - | p.29 |
| Regulatory source | - | =800 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 850 | mg/kg bw/d | mouse | oral | 90 days | - | p.17 |
| Regulatory source | - | 850 | mg/kg bw/day | mouse | oral | 90 days | - | p.26 |
| Regulatory source | - | 1000 | mg/kg bw/d | rat | oral | - | - | p.24 |
| Regulatory source | - | 1000 | mg/kg bw | - | oral | 13 weeks | - | p.24 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | 1000 | mg/kg | pig | - | 90 day | - | p.29 |
| Regulatory source | - | 1000 | mg/kg bw/day | mouse | oral | 90 day | - | p.29 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 30 day | - | p.28 |
| Regulatory source | - | 1340 | mg/kg bw | rat | oral | 90 days | - | p.25 |
| Regulatory source | - | =1340 | mg/kg bw/day | rat | oral | 90 day | - | p.29 |
| Regulatory source | - | =1340 | mg/kg bw/day | rat | - | 6-week | - | p.29 |
| Regulatory source | - | 1340 | mg/kg bw | rat | - | - | - | p.24 |
| Regulatory source | - | 1500 | mg/kg bw/d | rat | oral | - | - | p.18 |
| Regulatory source | - | 1500 | mg/kg bw | - | oral | 13 weeks | - | p.24 |
| Regulatory source | - | 1500 | mg/kg | dog | - | 90 day | - | p.29 |
| Regulatory source | - | 5360 | mg/kg | rat | - | 6-week | - | p.29 |
| Regulatory source | dermal absorption | =0.08 | mg/kg bw | human | dermal | - | dermal absorption | p.43 |
| Regulatory source | dermal absorption | 0.167 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | dermal absorption | =0.17 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| Regulatory source | dermal absorption | =0.19 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | dermal absorption | =0.2 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.29 |
| Regulatory source | dermal absorption | =0.62 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| Regulatory source | dermal absorption | =0.62 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | dermal absorption | =0.75 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.29 |
| Regulatory source | dermal absorption | 1.5 | % | human | dermal | - | dermal absorption | p.43 |
| Regulatory source | dermal absorption | =1.97 | mg/kg | rat | oral | 2 year | dermal absorption | p.23 |
| Regulatory source | dermal absorption | =1.97 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.28 |
| Regulatory source | dermal absorption | =3.16 | mg/kg bw/d | human | oral | - | dermal absorption | p.44 |
| Regulatory source | dermal absorption | =3.35 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | dermal absorption | 3.52 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | dermal absorption | =8.2 | mg/kg bw | dog | dermal | 13 week | dermal absorption | p.43 |
| Regulatory source | dermal absorption | 55.2 | % | rat | oral | 2 year | dermal absorption | p.23 |
| Regulatory source | dermal absorption | =200 | mg/kg | rat | oral | 2 year | dermal absorption | p.23 |
| Regulatory source | dermal absorption | 200 | mg/kg bw/d | rat | oral | - | dermal absorption | p.28 |
| Regulatory source | dermal absorption | =200 | mg/kg bw | rat | oral | 2 year | dermal absorption | p.28 |
| Regulatory source | dermal absorption | 400 | mg/kg bw/day | dog | dermal | 13 week | dermal absorption | p.43 |
| Regulatory source | dermal absorption | =400 | mg/kg bw | human | dermal | - | dermal absorption | p.44 |
| Regulatory source | dermal absorption | 400 | mg/kg bw/day | dog | oral | 13 week | dermal absorption | p.44 |
| Regulatory source | dermal absorption | =400 | mg/kg bw/d | human | dermal | - | dermal absorption | p.45 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/d | - | - | - | developmental toxicity | p.21 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | - | - | prenatal | developmental toxicity | p.34 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | rat | - | - | developmental toxicity | p.46 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/d | - | - | - | developmental toxicity | p.21 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw | - | - | Prenatal | developmental toxicity | p.34 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | rat | - | - | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | >2000 | mg/kg bw | - | - | prenatal | developmental toxicity | p.34 |
| Regulatory source | genotoxicity | 1 | % | rat | oral | 2 year | genotoxicity | p.47 |
| Regulatory source | genotoxicity | 200 | mg/kg bw/d | rat | oral | chronic | genotoxicity | p.19 |
| Regulatory source | genotoxicity | 400 | mg/kg bw/day | dog | - | 13 week | genotoxicity | p.46 |
| Regulatory source | genotoxicity | 400 | mg/kg bw/day | rat | oral | 13 week | genotoxicity | p.47 |
| Regulatory source | irritation | 98.6 | % | rat | inhalation | 5 days | irritation | p.21 |
| Regulatory source | irritation | 167 | mg/kg bw/d | rat | oral | - | irritation | p.30 |
| Regulatory source | irritation | 180 | mg/kg bw/day | rat | oral | - | irritation | p.24 |
| Regulatory source | irritation | 200 | mg/kg bw/day | rat | oral | 13 week | irritation | p.47 |
| Regulatory source | repeated dose toxicity | 1 | % | rat | oral | 12 days | repeated dose toxicity | p.22 |
| Regulatory source | repeated dose toxicity | 167 | mg/kg bw/day | rat | oral | 13 week | repeated dose toxicity | p.45 |
| Regulatory source | repeated dose toxicity | 180 | mg/kg bw/d | rat | oral | 9 months | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 180 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | =200 | mg/kg bw/day | rat | oral | 2 year | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | oral | 90 day | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | 13 weeks | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | 23 months | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/day | rat | oral | 90 day | repeated dose toxicity | p.26 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/day | rat | oral | 13 weeks | repeated dose toxicity | p.25 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | - | - | - | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | =400 | mg/kg bw/day | rat | oral | 90 day | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | dog | - | 13 week | repeated dose toxicity | p.30 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | rat | oral | 13 week | repeated dose toxicity | p.45 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | rat | oral | 2 year | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 800 | mg/kg bw/d | rat | oral | 23 months | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 800 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | oral | 2 year | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | oral | - | repeated dose toxicity | p.45 |
| Regulatory source | reproductive toxicity | 102 | ppm | - | - | - | reproductive toxicity | p.37 |
| Regulatory source | reproductive toxicity | 167 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 200 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 300 | mg/kg bw/d | rat | - | - | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 300 | mg/kg bw/d | rat | dermal | - | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 300 | mg/kg bw/day | rat | - | prenatal | reproductive toxicity | p.35 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | rat | - | developmental | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | rat | - | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | rat | dermal | - | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | - | - | reproductive toxicity | p.35 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | - | prenatal | reproductive toxicity | p.35 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | inhalation | - | reproductive toxicity | p.37 |
| Regulatory source | reproductive toxicity | 2000 | mg/kg bw/d | rat | oral | 63 days | reproductive toxicity | p.21 |
| Regulatory source | reproductive toxicity | 2000 | mg/kg bw/d | rat | oral | 20 days | reproductive toxicity | p.21 |
| Regulatory source | reproductive toxicity | 2000 | mg/kg bw | rat | oral | 10 days | reproductive toxicity | p.36 |
| Regulatory source | reproductive toxicity | 2000 | mg/kg bw | rat | dermal | 10 days | reproductive toxicity | p.36 |
| Regulatory source | reproductive toxicity | 2000 | mg/kg bw | rat | oral | prenatal | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | >2000 | mg/kg bw | - | - | prenatal | reproductive toxicity | p.35 |
| Regulatory source | reproductive toxicity | 2200 | mg/kg bw/d | rat | - | 10 days | reproductive toxicity | p.33 |
| Regulatory source | reproductive toxicity | 29190 | - | rat | oral | - | reproductive toxicity | p.52 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | A1A1I8X02B | UNII | - | - | - | chemical | - |