NOAEL Studies
Cosmetic Ingredient
2-Ethoxyethanol NOAEL Studies
INCI: ETHOXYETHANOL
CAS: 110-80-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 122 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 185.8 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 28 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 39 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 255 | mg/kg bw/day | rat | oral | 63 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 35 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 321 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 357 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 2 day | Immunotoxicology | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 407 | mg/kg bw/day | rat | oral | 60 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 11 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 800 | mg/kg bw/day | mouse | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 936 | mg/kg bw/day | rat | oral | 5 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | mouse | oral | 7 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | mouse | oral | 126 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1890 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2583 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3574.5 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3605 | mg/kg bw/day | mouse | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3750 | mg/kg bw/day | mouse | oral | 18 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5123 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | SQEinhalation=960; oral=750 | ug/day | - | - | 1989-01-01 | Maximum allowable dose level | - |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental, male | listing type | - | - | 1989-01-01 | California Proposition 65 listing | - |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL (HEC) | =68 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=f1a786bd7d87487e; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 6.8e1 mg/m^3; system=Reproductive, Hematologic; basis=Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin; point_of_departure=NOAEL (HEC): 6.8e1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID7024087; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; rfc_last_updated=05/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0513_summary.pdf |
| Regulatory source | RfC | =0.2 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=261028a42b4d9583; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e-1; system=Reproductive, Hematologic; basis=Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin; point_of_departure=NOAEL (HEC): 6.8e1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID7024087; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; rfc_last_updated=05/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0513_summary.pdf |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 7.3674 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3926; Record_ID=acute_inhalation_1100; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7024087; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.3674; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
| NTP ICE acute inhalation | LC50 | 7.36 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3927; Record_ID=acute_inhalation_680; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7024087; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.36; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14915/7/3/3/?documentUUID=7374ac04-1152-4b53-9f79-5239248c5253; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
| NTP ICE acute inhalation | LC50 | >14.7347 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3928; Record_ID=acute_inhalation_1628; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7024087; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=14.7347; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1746 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_949; row=11884; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethoxyethanol; preferred_name=2-Ethoxyethanol; dtxsid=DTXSID7024087; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024087; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1519 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_948; row=11885; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethoxyethanol; preferred_name=2-Ethoxyethanol; dtxsid=DTXSID7024087; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024087; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_952; row=11886; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethoxyethanol; preferred_name=2-Ethoxyethanol; dtxsid=DTXSID7024087; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024087; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3460 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_951; row=11887; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethoxyethanol; preferred_name=2-Ethoxyethanol; dtxsid=DTXSID7024087; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024087; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2125 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_950; row=11888; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethoxyethanol; preferred_name=2-Ethoxyethanol; dtxsid=DTXSID7024087; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024087; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2304; RecordID=ARPathway2016_552; DatasetName=ARPathway2016; DTXSID=DTXSID7024087; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 15 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4816; Record_ID=skin_irritation_invitro_162; Data_Type=In Vitro; Formulation_ID=MIX800; Formulation_Name=sulfuric acid + cellusolve; Percent_Active_Ingredient=20; Mixture=Mixture; DTXSID=DTXSID7024087; Assay=Corrositex; Endpoint=Breakthrough Time; Response=15; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
| NTP ICE skin irritation | Breakthrough Time | 240 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4818; Record_ID=skin_irritation_invitro_70; Data_Type=In Vitro; Formulation_ID=MIX785; Formulation_Name=Cellosolve + TX100; Mixture=Mixture; DTXSID=DTXSID7024087; Assay=Corrositex; Endpoint=Breakthrough Time; Response=240; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024087; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024087 |
EPA ToxRefDB v3 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5517; toxval_study_source_id=studyid5517_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-mortality-mortality|pathology gross-stomach-ulcer; dose_level=1; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EEGE Chronic rat); dsstox_substance_id=DTXSID7024087; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =2000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5518; toxval_study_source_id=studyid5518_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=3; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); dsstox_substance_id=DTXSID7024087; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =804 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal|reproductive performance-estrous cycle-length; dose_level=4; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =122 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-water consumption-water consumption|hematology-platelet-platelet|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-body weight-body weight|hematology-hematocrit (hct)-hematocrit (hct)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight gain|clinical chemistry-protein-protein|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-liver-hematopoietic cell proliferation|pathology microscopic-thymus-atrophy|pathology microscopic-uterus-atrophy|clinical chemistry-albumin-albumin|hematology-neutrophils-neutrophils|organ weight-thymus-absolute|organ weight-thymus-relative to body weight|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-liver-pigmentation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-bone marrow-depletion cellular|pathology microscopic-spleen-pigmentation|in life observation-mortality-mortality|pathology microscopic-spleen-atrophy|pathology microscopic-liver-degeneration; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =109 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-thymus-relative to body weight|pathology gross-sperm measure-sperm count|pathology microscopic-prostate-atrophy|organ weight-thymus-absolute|hematology-platelet-platelet|pathology microscopic-spleen-hematopoietic cell proliferation|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-body weight-body weight gain|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-epididymis-nos|pathology microscopic-testes-degeneration|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-protein-protein|clinical chemistry-albumin-albumin|organ weight-testes-relative to body weight|organ weight-testes-absolute|pathology gross-testes-reduced size|pathology microscopic-thymus-atrophy|pathology gross-sperm measure-sperm motility|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|hematology-neutrophils-neutrophils|in life observation-body weight-body weight|pathology microscopic-liver-hematopoietic cell proliferation|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-liver-pigmentation|pathology microscopic-liver-degeneration|pathology microscopic-spleen-pigmentation|pathology microscopic-spleen-atrophy|pathology microscopic-bone marrow-depletion cellular|in life observation-mortality-mortality|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =722 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =2725 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-adrenal gland-hypertrophy|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-clinical signs-emaciation|in life observation-body weight-body weight gain; dose_level=3; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =5123 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|organ weight-testes-absolute|in life observation-clinical signs-emaciation|organ weight-epididymis-nos|pathology gross-sperm measure-sperm motility|pathology gross-sperm measure-sperm count|pathology microscopic-testes-degeneration|pathology gross-testes-reduced size|pathology gross-epididymis-reduced size|pathology microscopic-spleen-hematopoietic cell proliferation; dose_level=4; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =792 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult_F0_M_systemic; toxval_effect_list=organ weight-testes-relative to body weight|organ weight-testes-absolute|pathology gross-testes-reduced size|pathology gross-sperm measure-sperm motility|pathology microscopic-testes-degeneration|in life observation-body weight-body weight|pathology microscopic-liver-hematopoietic cell proliferation|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-body weight-body weight gain|pathology microscopic-bone marrow-hyperplasia|pathology gross-sperm measure-sperm count|pathology microscopic-liver-pigmentation; dose_level=4; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =7255 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-body weight-body weight gain; dose_level=4; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=5517; toxval_study_source_id=studyid5517_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|pathology gross-stomach-ulcer|in life observation-body weight-body weight; dose_level=0; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EEGE Chronic rat); dsstox_substance_id=DTXSID7024087; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5518; toxval_study_source_id=studyid5518_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=2; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); dsstox_substance_id=DTXSID7024087; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =500 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=5518; toxval_study_source_id=studyid5518_Adult_F0_M_systemic; toxval_effect_list=in life observation-mortality-mortality|pathology gross-stomach-ulcer|pathology gross-testes-reduced size; dose_level=1; study_year=1984; study_citation=Melnick, R. L. (1984). 'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); dsstox_substance_id=DTXSID7024087; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =466 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal|reproductive performance-estrous cycle-length; dose_level=3; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1304 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-adrenal gland-hypertrophy|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-clinical signs-emaciation|in life observation-body weight-body weight; dose_level=2; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =2003 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5528; toxval_study_source_id=studyid5528_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-testes-degeneration|pathology gross-testes-reduced size|pathology gross-sperm measure-sperm count|in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-epididymis-absolute|organ weight-testes-absolute|in life observation-clinical signs-emaciation|organ weight-epididymis-nos|pathology gross-epididymis-reduced size|pathology microscopic-spleen-hematopoietic cell proliferation|pathology gross-sperm measure-sperm motility; dose_level=3; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE mouse); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =400 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5527; toxval_study_source_id=studyid5527_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-hematopoietic cell proliferation|pathology microscopic-spleen-hematopoietic cell proliferation|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-body weight-body weight gain|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|in life observation-mortality-mortality|pathology microscopic-bone marrow-hyperplasia|organ weight-thymus-relative to body weight|pathology gross-sperm measure-sperm count|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-liver-pigmentation|clinical chemistry-albumin-albumin|organ weight-testes-relative to body weight|pathology microscopic-bone marrow-depletion cellular|organ weight-testes-absolute|pathology gross-testes-reduced size|hematology-platelet-platelet|pathology microscopic-thymus-atrophy|pathology microscopic-spleen-atrophy|organ weight-epididymis-nos|pathology gross-sperm measure-sperm motility|in life observation-water consumption-water consumption|pathology microscopic-spleen-pigmentation|pathology microscopic-liver-degeneration|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-testes-degeneration|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-prostate-atrophy|organ weight-thymus-absolute|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-epididymis-absolute|hematology-neutrophils-neutrophils|in life observation-body weight-body weight|clinical chemistry-protein-protein; dose_level=3; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (EGEE rat); dsstox_substance_id=DTXSID7024087; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =36.8599 | mg/m3 | Rat | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Tinston DJ, Doe JE, Godley MJ, Head LK, Killick M, Litchfield MH, et al. Ethylene glycol monoethyl ether (EE): teratogenicity study in rats. Imperial Chemical Industries PLC. Report No. CTL/P/761 to Chemical Manufacturers Association 1983; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=specific skeletal defects, including delayed ossification of the cervical vertebrae and sternebrae and extra ribs; STUDY_GROUP=Cal OEHHA REL derivations:15951928:F:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe2977ff8b75d7dc3a1ebfeff4d10301 |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =379.657 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Barbee SJ, Terrill JB, DeSousa DJ, and Conaway CC. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and the rabbit. Environ. Health Perspect 57:157-163.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Testicular degeneration and decreased hemoglobin levels; STUDY_GROUP=Cal OEHHA REL derivations:15952062:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40afa27824d2a29d602c8e5bc7638fc4 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =62661.8 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15515249:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_923addbe04655566f1817a4c0eb3b5f5 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =3605 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15612576:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9a22a2117d0221475fcbddb549208aec |
ToxValDB EPA HWIR 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA HWIR | NOAEL (ADJ) | =68 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Barbee, S.J., J.B. Terrill, D.J. DeSousa, and C.C. Conaway. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit. Environ Health Perspect 57: 157-163.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Decreased testis weight, seminiferous tubule degeneration, and decreased hemoglobin (2-ethoxyethanol); STUDY_GROUP=EPA HWIR:15952203:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_104121512cc4fa35450f78e4621b44a5 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.083 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631895:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89b31053cb647196f37ce9c8f5f9df6a |
ToxValDB HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <190 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e18e4b0a676289df83b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=clinical observation: emaciation, diarrhea, abnormal posture, tremors; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=HESS:15638235:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4137b17395e661be66913b2ec9d83e1f |
| ToxValDB HESS | NOEL | =122 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e18e4b0a676289df83b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=clinical observation: emaciation, diarrhea, abnormal posture, tremors; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=HESS:15638944:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49fdc221c7c27614cec6d164d0a8b7d4 |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =1485 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit. Environ. Health Perspect. 57: 157-163.; TITLE=Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit; AUTHOR=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; TOXICOLOGICAL_EFFECT=reduced testes weight, seminiferous tubule degeneration and reduced hemoglobin; STUDY_GROUP=IRIS_dup_IRIS Summary_15644132_15644133_15644134_15644135_15644136_15644137:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c251a601180c2fed5ed853465da526d |
| ToxValDB IRIS | LOAEL (ADJ) | =265 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit. Environ. Health Perspect. 57: 157-163.; TITLE=Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit; AUTHOR=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; TOXICOLOGICAL_EFFECT=reduced testes weight, seminiferous tubule degeneration and reduced hemoglobin; STUDY_GROUP=IRIS_dup_IRIS Summary_15644132_15644133_15644134_15644135_15644136_15644137:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4ee9bc0e38a6d9a5934d27c2aa0facd |
| ToxValDB IRIS | NOAEL | =380 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit. Environ. Health Perspect. 57: 157-163.; TITLE=Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit; AUTHOR=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; TOXICOLOGICAL_EFFECT=reduced testes weight, seminiferous tubule degeneration and reduced hemoglobin; STUDY_GROUP=IRIS_dup_IRIS Summary_15644132_15644133_15644134_15644135_15644136_15644137:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a0b145c135742c69318c00800b832679 |
| ToxValDB IRIS | RfC | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway. 1984. Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit. Environ. Health Perspect. 57: 157-163.; TITLE=Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit; AUTHOR=Barbee, S.J., J.B. Terrill, D.J. DeSousa and C.C. Conaway; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=513; TOXICOLOGICAL_EFFECT=Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin in male/female rabbits; STUDY_GROUP=IRIS:15644138:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_afb2445250ae21199933357b9fe430f6 |
ToxValDB PPRTV (CPHEA) 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (05 HEC) | =4.23 | mg/m3 | Rabbit | inhalation | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Doe 1984b; AUTHOR=Doe; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1741; TOXICOLOGICAL_EFFECT=skeletal effects; STUDY_GROUP=PPRTV (CPHEA):15653290:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8d00284ba85b68186c644b735f9f63e8 |
| ToxValDB PPRTV (CPHEA) | BMDL (10) | =33.7 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP 1993a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1741; TOXICOLOGICAL_EFFECT=atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=PPRTV (CPHEA):15653934:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9ef9d3514b9ddaca2714a666bfa52944 |
| ToxValDB PPRTV (CPHEA) | NOAEL (ADJ) | =86 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=Yoon et al. 2003; AUTHOR=Yoon et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1741; TOXICOLOGICAL_EFFECT=pathological effects; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=PPRTV (CPHEA):15654022:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b97c4d489e05ce0483a2e1ac7be2f6eb |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.04 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Doe 1984b; AUTHOR=Doe; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1741; TOXICOLOGICAL_EFFECT=Increase of offspring showing major skeletal effects in male/female rabbits; STUDY_GROUP=PPRTV (CPHEA):15653289:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_250262ee97056e28212035fde1853027 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NTP 1993a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1741; TOXICOLOGICAL_EFFECT=Atrophy in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653621:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_150237c7f08280ba9bc8eb0cc740a142 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.09 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650100:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bbd975d5d5b1bd32a3ec98fcd5255a8c |
ToxValDB ToxRefDB 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =500 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EEGE Chronic rat); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5517; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology gross-stomach-ulcer|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709426_15709427:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de76ffd0923fdab692a1fde980c7ea9d |
| ToxValDB ToxRefDB | LEL | =2000 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5518; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709430_15709431:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f27535738d2b3cb274bac4f67e5e3429 |
| ToxValDB ToxRefDB | LEL | =804 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal|reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709474_15709475:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc0b53862a646e308320b77ee90cd217 |
| ToxValDB ToxRefDB | LEL | =109 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-platelet-platelet|systemic: pathology microscopic-prostate-atrophy|systemic: organ weight-thymus-absolute|systemic: organ weight-thymus-relative to body weight|systemic: pathology gross-sperm measure-sperm count|systemic: pathology microscopic-testes-degeneration|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight gain|systemic: organ weight-epididymis-nos|systemic: clinical chemistry-protein-protein|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-albumin-albumin|systemic: organ weight-testes-relative to body weight|systemic: pathology microscopic-liver-hematopoietic cell proliferation|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: organ weight-testes-absolute|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-thymus-atrophy|systemic: hematology-neutrophils-neutrophils|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-liver-pigmentation|systemic: pathology microscopic-spleen-pigmentation|systemic: in life observation-mortality-mortality|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: pathology microscopic-spleen-atrophy|systemic: pathology microscopic-bone marrow-depletion cellular|systemic: pathology microscopic-liver-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709479_15709480_15709481:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83f645f09e845297e19f12952bb802d4 |
| ToxValDB ToxRefDB | LEL | =722 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB:15709482:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f291cc7a9d20b0e3377a736b3db4882 |
| ToxValDB ToxRefDB | LEL | =2725 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-hypertrophy|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: in life observation-clinical signs-emaciation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709483_15709484_15709485_15709486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73e4ad49c97c67c1ff573581ae1c4030 |
| ToxValDB ToxRefDB | LEL | =5123 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: organ weight-testes-absolute|systemic: pathology gross-sperm measure-sperm count|systemic: organ weight-epididymis-nos|systemic: in life observation-clinical signs-emaciation|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-testes-reduced size|systemic: pathology gross-epididymis-reduced size|systemic: pathology microscopic-spleen-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709487_15709488_15709489_15709490:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d667f31609ead0082f121ffafd32ff74 |
| ToxValDB ToxRefDB | LOAEL | =792 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-testes-relative to body weight|systemic: pathology microscopic-liver-hematopoietic cell proliferation|systemic: organ weight-testes-absolute|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-sperm measure-sperm count|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-liver-pigmentation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709479_15709480_15709481:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e9017708a9fc79a1a5f30b229bd4fac |
| ToxValDB ToxRefDB | LOAEL | =7255 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-spleen-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709483_15709484_15709485_15709486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_39b1f7e414cb7cb51b362c45d06228ac |
| ToxValDB ToxRefDB | NEL | =1000 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5518; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709430_15709431:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f25b83c5a7a0222f4f7d426a4f5518f9 |
| ToxValDB ToxRefDB | NEL | =500 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=Melnick, R. L. (1984). \'Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice.\' Environ Health Perspect 57: 147-155. (EGEE Chronic mouse); TITLE=Toxicities of ethylene glycol and ethylene glycol monoethyl ether in Fischer 344/N rats and B6C3F1 mice; AUTHOR=Melnick, R. L; EXTERNAL_SOURCE_ID=5518; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=systemic: pathology gross-testes-reduced size|systemic: in life observation-mortality-mortality|systemic: pathology gross-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709432_15709433:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c20f20be8d7175c44d6e37f7bf4dff5 |
| ToxValDB ToxRefDB | NEL | =466 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal|reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709474_15709475:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0316f4dc5fd86416f1d1332c28a92281 |
| ToxValDB ToxRefDB | NEL | =1304 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-hypertrophy|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: in life observation-clinical signs-emaciation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709483_15709484_15709485_15709486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_584f006e101984a54712ef9271f31033 |
| ToxValDB ToxRefDB | NEL | =2003 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-epididymis-nos|systemic: in life observation-body weight-body weight gain|systemic: organ weight-epididymis-absolute|systemic: organ weight-testes-absolute|systemic: pathology gross-sperm measure-sperm count|systemic: pathology gross-epididymis-reduced size|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: in life observation-body weight-body weight|systemic: pathology gross-sperm measure-sperm motility|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-testes-reduced size; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709487_15709488_15709489_15709490:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_106b343cfe3116440c6d17626a4830e9 |
| ToxValDB ToxRefDB | NOAEL | =400 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (EGEE rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-degeneration|systemic: clinical chemistry-albumin-albumin|systemic: organ weight-testes-relative to body weight|systemic: pathology microscopic-bone marrow-depletion cellular|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-testes-degeneration|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: organ weight-testes-absolute|systemic: pathology gross-testes-reduced size|systemic: hematology-platelet-platelet|systemic: pathology microscopic-liver-hematopoietic cell proliferation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-prostate-atrophy|systemic: organ weight-thymus-absolute|systemic: pathology microscopic-thymus-atrophy|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: organ weight-epididymis-absolute|systemic: hematology-neutrophils-neutrophils|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-spleen-atrophy|systemic: organ weight-epididymis-nos|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: pathology gross-sperm measure-sperm motility|systemic: clinical chemistry-protein-protein|systemic: in life observation-water consumption-water consumption|systemic: pathology gross-sperm measure-sperm count|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-spleen-pigmentation|systemic: pathology microscopic-liver-pigmentation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709479_15709480_15709481:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c253591241d5fee015d411469e38aca8 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | IDK7C2HS09 | UNII | - | - | - | chemical | - |