NOAEL Studies Cosmetic Ingredient

Ethyl Butyrate NOAEL Studies

INCI: ETHYL BUTYRATE

CAS: 105-54-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =13000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_472; row=10777; data_type=In Vivo; mixture=Chemical; chemical_name=Ethyl butyrate; preferred_name=Ethyl butyrate; dtxsid=DTXSID6040111; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040111; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6040111; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9070; RecordID=ARPathway2016_458; DatasetName=ARPathway2016; DTXSID=DTXSID6040111; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040111; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040111
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2759; Record_ID=skin_sensitization_invivo_734; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040111; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90250-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040111; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040111
NTP_ICE_skin_sensitization Induction dose per skin area 3240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2758; Record_ID=skin_sensitization_invivo_734; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040111; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90250-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040111; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040111
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2761; Record_ID=skin_sensitization_invivo_734; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6040111; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90250-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040111; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6040111
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =49.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631935:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2b24898cfb1eedc0c07b3aef3ba058a
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=15 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb37e4b0d99f5a87a816; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/106; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=WHO JECFA ADI:15715322:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a74f3e70cdb05741521a4f033ae870c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier UFD2LZ005D UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UFD2LZ005D"}
openFDA substances FDA UNII substance identifier UFD2LZ005D UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UFD2LZ005D"}
openFDA substances FDA UNII substance identifier UFD2LZ005D UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UFD2LZ005D"}
openFDA substances FDA UNII substance identifier UFD2LZ005D UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UFD2LZ005D"}