Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Ethyl Butyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.06 mg/L air | 1991 | rat | inhalation | REACH |
| NOAEL | 14.4 other | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Ethyl Butyrate is an unrestricted Cramer Class I fragrance ester with MOEs exceeding 40,000x, no allergen-labeling requirement, and no IFRA limits.
Regulatory Flags
Frequently Asked Questions
Is Ethyl Butyrate safe in cosmetics?
Ethyl Butyrate is an unrestricted Cramer Class I fragrance ester with MOEs exceeding 40,000x, no allergen-labeling requirement, and no IFRA limits. The EU classifies Ethyl Butyrate as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.
Is Ethyl Butyrate allowed in the EU?
Ethyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Butyrate do in cosmetics?
Ethyl Butyrate functions as: Perfuming, Masking. It is classified as a Cosmetic Ingredient in our database. CAS number: 105-54-4.
What is the Margin of Safety for Ethyl Butyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethyl Butyrate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Butyrate is 0.06 mg/L air based on a inhalation study via 1991 route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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