NOAEL Studies
Cosmetic Ingredient
Ethyl Hexanediol NOAEL Studies
INCI: ETHYL HEXANEDIOL
CAS: 94-96-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11655; row=7297; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1,3-hexanediol; preferred_name=2-Ethyl-1,3-hexanediol; dtxsid=DTXSID4025292; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4025292; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4025292; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4636 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_11657; row=7296; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1,3-hexanediol; preferred_name=2-Ethyl-1,3-hexanediol; dtxsid=DTXSID4025292; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4025292; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4025292; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9281 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_11636; row=7298; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1,3-hexanediol; preferred_name=2-Ethyl-1,3-hexanediol; dtxsid=DTXSID4025292; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4025292; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4025292; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2312; RecordID=ARPathway2016_1752; DatasetName=ARPathway2016; DTXSID=DTXSID4025292; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4025292; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4025292 |
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =215 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217c48; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/8?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15818114:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_716387a38204a84bff2482b0cf9a0026 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf7fe4b0a7c65d1ce1b6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/6/2?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15850012:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a7983030c302886b029da5201b16745 |
| ECHA | NOAEL | =466 | mg/kg bw/day | Dog | oral | chronic; 394 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf7fe4b0a7c65d1ce1c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/6/2?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15848854:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c591c661a693dd484053d2f2398d0b73 |
| ECHA | NOAEL | =480 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf7fe4b0a7c65d1ce1aa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/6/2?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15850011:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f52974a045baad724f166abd26b71d7d |
| ECHA | NOAEL | =932.5 | mg/kg bw/day | Rabbit | dermal | chronic; 25 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e18e4b096bca8778576; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/6/4?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15826403:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_058f4b341b7860127380b9f360f230ae |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfcf6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/9/3?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15825312:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ec7f883600b6028c9213d1e74148f8f6 |
| ECHA | NOAEL | =1884 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774f59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/6/4?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15826087:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5fe8540b48c6115db4847785c629037b |
| ECHA | NOAEL | >3768 | mg/kg bw/day | Rat | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c96de4b0a7c65d21ce73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/9/2?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15857211:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_275a5d017779764103d214ab92e0e776 |
| ECHA | NOEL | =942 | mg/kg bw/day | Rat | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d23269e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13598/7/9/3?documentUUID=3ecfb8be-eb7c-429e-9088-5defe3c50c0d; YEAR=1958; ORIGINAL_YEAR=1958; STUDY_GROUP=ECHA IUCLID:15822784:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_281c199821f3434399b40f0c151c785d |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | M9JGK7U88V | UNII | - | - | - | chemical | - |