Also known as: 4-01-00-02597, 6-12 insect repellent, BRN 1735324, Carbide 6-12, Caswell No. 445 (+5 more)
INCI: ETHYL HEXANEDIOL
Ethyl Hexanediol (CAS 94-96-2) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =100 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Ethyl Hexanediol is classified GHS Danger (H318, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Hexanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
6 study endpoints found for Ethyl Hexanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | short-term | ECHA |
| NOAEL | =466 mg/kg bw/day | oral | Dog | chronic | ECHA |
| NOAEL | =480 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =932.5 mg/kg bw/day | dermal | Rabbit | chronic | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =1884 mg/kg bw/day | dermal | Rat | subchronic | ECHA |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for Ethyl Hexanediol — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Ethyl Hexanediol by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Ethyl Hexanediol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 6 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Ethyl Hexanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Ethyl Hexanediol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 94-96-2.
The NOAEL (No Observed Adverse Effect Level) for Ethyl Hexanediol is =100 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 6 study endpoints are available. Source: ECHA.
Ethyl Hexanediol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Ethyl Hexanediol is classified GHS Danger (H318, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Check Ethyl Hexanediol compliance across multiple jurisdictions:
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