NOAEL Studies Preservative

Ethyl Lauroyl Arginate HCl NOAEL Studies

INCI: ETHYL LAUROYL ARGINATE HCL

CAS: 60372-77-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 2000 ppm rat oral 52 week Chronic SCCP; Kilpatrick, H.; Akintomide, A.; Waterson, L. Lauric arginate. Toxicity study by dietaryadministration to CD rats for 52 weeks. Huntingdon Life Science. Report, Studynumber LMA 050/042556, November, 2005. (Annex 8)
EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =47 mg/kg bw/day Rat oral: unspecified 91 days subchronic EFSA AFC - 2007 - OutputID 297 - clinical chemistry - immunotoxicity - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of ethyl lauroyl arginate as a food additive - doi:10.2903/j.efsa.2007.511
EFSA ADI =0.5 mg/kg bw/day Consumers - - ADI EFSA AFC - 2007 - OutputID 297 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of ethyl lauroyl arginate as a food additive - doi:10.2903/j.efsa.2007.511
EFSA NOAEL =47 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of ethyl lauroyl arginate as a food additive. doi:10.2903/j.efsa.2007.511.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to an application on the use of ethyl lauroyl arginate as a food additive; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.511; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15614255:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd437221eb9168e1c120588760bd9904
SCCS Opinion 41 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0 - - oral - reproductive toxicity p.45
SCCS Opinion NOAEL =0.0897 mg/kg bw/d human oral - NOAEL study (Ref. 6), p.18
SCCS Opinion NOAEL =0.4 % - dermal - dermal absorption p.55
SCCS Opinion NOAEL =0.4 % - oral - dermal absorption p.26
SCCS Opinion NOAEL =0.442 mg/kg bw/day - oral 9 years NOAEL study p.18
SCCS Opinion NOAEL =0.8 % - oral 28 day repeated dose toxicity p.12
SCCS Opinion NOAEL =1.19 mg/kg/d rat oral chronic dermal absorption p.55
SCCS Opinion NOAEL =1.24 mg/kg/d human inhalation chronic reproductive toxicity p.55
SCCS Opinion NOAEL =6 - - oral - NOAEL study p.12
SCCS Opinion NOAEL =6 - - oral 28 day NOAEL study p.12
SCCS Opinion NOAEL =7 - rat oral - reproductive toxicity p.45
SCCS Opinion NOAEL =12 - rat oral sub-chronic repeated dose toxicity p.40
SCCS Opinion NOAEL =13 - rat - sub-chronic repeated dose toxicity p.30
SCCS Opinion NOAEL =20.2 % rat - - irritation Ref.: 16 Mirenat-N Guideline : OECD No, p.23
SCCS Opinion NOAEL =26 - rat oral chronic NOAEL study p.26
SCCS Opinion NOAEL =28 - - - 28 day NOAEL study p.31
SCCS Opinion NOAEL =31 - - oral - NOAEL study p.31
SCCS Opinion NOAEL =55 - rat oral chronic NOAEL study p.55
SCCS Opinion NOAEL =56 mg/kg bw/day rat oral 13-week NOAEL study p.18
SCCS Opinion NOAEL =69.1 % rabbit - - NOAEL study p.34
SCCS Opinion NOAEL =93.2 % rat - - irritation p.38
SCCS Opinion NOAEL =95 - - dermal - NOAEL study p.20
SCCS Opinion NOAEL =106 mg/kg bw/day rat - 90-day NOAEL study (ref 18), p.56
SCCS Opinion NOAEL =173 - rabbit - - NOAEL study p.36
SCCS Opinion NOAEL =183 - - oral - NOAEL study p.12
SCCS Opinion NOAEL =207 mg/kg bw/day - oral subchronic repeated dose toxicity p.57
SCCS Opinion NOAEL =207 mg/kg bw/day rat - chronic reproductive toxicity p.13
SCCS Opinion NOAEL =271 mg/kg bw/day - oral 28 day NOAEL study p.31
SCCS Opinion NOAEL =271 mg/kg bw/d human inhalation chronic repeated dose toxicity p.55
SCCS Opinion NOAEL =271 mg/kg bw/day rat oral chronic dermal absorption p.26
SCCS Opinion NOAEL =271 mg/kg bw/d - oral - dermal absorption p.26
SCCS Opinion NOAEL =271 mg/kg bw/day - oral 28 day repeated dose toxicity p.12
SCCS Opinion NOAEL =271 - - oral Chronic NOAEL study p.12
SCCS Opinion NOAEL =271 mg/kg bw/day rat - Chronic repeated dose toxicity p.13
SCCS Opinion NOAEL =346 mg/kg bw/day rat - - irritation p.26
SCCS Opinion NOAEL =346 - - oral chronic NOAEL study p.12
SCCS Opinion NOAEL =837 - rat oral sub-chronic repeated dose toxicity p.40
SCCS Opinion NOAEL =837 - - oral sub-chronic repeated dose toxicity p.55
SCCS Opinion NOAEL =6000 ppm - oral 28 day repeated dose toxicity p.29
SCCS Opinion NOAEL =15000 ppm rat - - reproductive toxicity p.48
SCCS Opinion NOAEL =unclear:orted that the difficulties with dosing were reduced when the surface of the catheter was washed clean and used damp rather than wiped dry before dose administration but did not provide the data. Since this was a reproductive study, the histopathology of the stomach was not investigated. In reply to a letter requesting interpretation of the embryo-foetal studies, the head of Reproductive Studies Group of the Testing Laboratory stated that the effect was not a systemic toxic response. He went on to say ‘to base the NOAEL on results of dietary studies should be considered in the light of the proposed route of administration for use in the material in cosmetics. It should be acceptable if the material is applied as a lotion to the body skin, but might be less acceptable if applied as a spray or to the lip/face.” - - oral - reproductive toxicity p.40
ECHA 29 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =1000 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be25f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822785_15822897_15823390:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aee43302039af321a034266f64be2f33
ECHA LEL =1270 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855110_15861866:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a0b6dfe17f51069cda99ffbbb01df45
ECHA LEL =1330 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855993_15856337_15856761_15860683:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be32db84845f0e954343caaf5f8fe09f
ECHA LEL =2000 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be25b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823386_15823505:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4377079176b65d9163fa73abf914b4b8
ECHA LOAEL =907 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c980e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833683_15849612:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c45aefcea3547478a59e48a4b2e7ba19
ECHA LOAEL =1128 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c980e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833684_15849611:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_935b38f1de873a26ef6d5217d5231d5f
ECHA NOAEL =175 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb75e4b0a7c65d226259; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833991_15849615:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff721d7a3534c55ca90f33cb27c259b8
ECHA NOAEL =200 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be262; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=maternal: clinical signs|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15824997:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49aadd594b9ffff23118c2227a174cd3
ECHA NOAEL =207 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb75e4b0a7c65d226259; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833992_15849614:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e22eed250abd233a3501576fb3f7461a
ECHA NOAEL =300 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be255; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822785_15822897_15823390:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37b6a9917a66b6740661f32e8ce1da29
ECHA NOAEL =307 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c980e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833683_15849612:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37713021e411a80b30f2fcb943a4e510
ECHA NOAEL =384 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9814; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=stomach: body weight and weight gain|clinical signs|food consumption and compound intake|food efficiency|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833991_15849615:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee7acfd1402e83ee4345ccd66a4d66f8
ECHA NOAEL =393 mg/kg bw/day Rat oral chronic; 52 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c980e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833684_15849611:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66c4ba017cfeac5815d06b14a9f42d23
ECHA NOAEL =445 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9814; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=stomach: body weight and weight gain|clinical signs|food consumption and compound intake|food efficiency|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833992_15849614:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_78ff9b9b4bd286bdf000d2fa35541c66
ECHA NOAEL =480 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9814; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=stomach: body weight and weight gain|clinical signs|food consumption and compound intake|food efficiency|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|other; STUDY_GROUP=ECHA IUCLID:15849613:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a164546181aa846e19b7b891098c7b9a
ECHA NOAEL =1027.45 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb75e4b0a7c65d22624f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15848997:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_29af3803176878f0b0817dc7b677d105
ECHA NOAEL =1073 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855110_15861866:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4873b7cb5ed0809508ea4ca8497ea8e
ECHA NOAEL =1139.97 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb75e4b0a7c65d22624f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15848249:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_978e5331dbc42b2acb014e9c6a69e4af
ECHA NOAEL =1226 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855993_15856337_15856761_15860683:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb1005f42134e10d0133af6a766c0600
ECHA NOAEL =1356 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15861977:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a605b6ceb491fd8df837a2dffd509885
ECHA NOAEL =1430 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=F1: test mat.; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858527_15858635_15858764:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56a72024827567603104506d7196d123
ECHA NOAEL =1489 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858527_15858635_15858764:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef4d1e5fedda5148d4a3d0323b4f3744
ECHA NOAEL =1518 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855993_15856337_15856761_15860683:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_335c39ad92399ee7d47c5fdcfc45518b
ECHA NOAEL =2000 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be262; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15824996:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_268d067021777206a88a5d04ba4e7fc9
ECHA NOAEL =2353 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15860578:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d41c6161a8a4c288d63a6ed884f75649
ECHA NOAEL =2600 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855993_15856337_15856761_15860683:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dc11a4b9d1a20eee3d7e04ca755cce3c
ECHA NOAEL =50000 ppm Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9811; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15839178:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53084998d07ab3aedb9c34543561f639
ECHA NOEL =250 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230c66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822785_15822897_15823390:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8bc07269d9ca8dfc8b913c6ed5bbcad8
ECHA NOEL =1000 mg/kg bw/day Rabbit oral - developmental GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230c66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/16635?documentUUID=2ca81669-f7b1-4987-9206-6befb68e6146; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821471_15823711:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1908c6c108fc3a56e5bd32d46519061
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =21.652 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631955:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48325fcc547c8a1777581cd3183798ea
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI <=4 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afda2e4b0d99f5a87eca7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5865; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=WHO JECFA ADI:15715507:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e5e53e526ac30e48f560ebde5579b42
Regulatory source 49 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - =0.0897 mg/kg bw/d human oral - - p.18
Regulatory source - 0.4 % - oral - - p.27
Regulatory source - 0.442 mg/kg bw/day - oral 9 years - p.18
Regulatory source - 0.442 mg/kg bw/day - oral 3 year - p.20
Regulatory source - 6 - - oral - - p.12
Regulatory source - 6 - - oral 28 day - p.12
Regulatory source - 26 - rat oral chronic - p.26
Regulatory source - 28 - - - 28 day - p.31
Regulatory source - 31 - - oral - - p.31
Regulatory source - 31 - - - - - p.31
Regulatory source - 55 - rat oral chronic - p.55
Regulatory source - 56 mg/kg bw/day rat oral 13-week - p.18
Regulatory source - 69.1 % rabbit - - - p.34
Regulatory source - 95 - - dermal - - p.20
Regulatory source - 106 mg/kg bw/day rat - 90-day - p.56
Regulatory source - 173 - rabbit - - - p.36
Regulatory source - 183 - - oral - - p.12
Regulatory source - 271 mg/kg bw/day - oral 28 day - p.31
Regulatory source - 271 mg/kg bw/day - - chronic - p.31
Regulatory source - 271 mg/kg bw/day - - - - p.55
Regulatory source - 271 - - oral Chronic - p.12
Regulatory source - 271 mg/kg bw/day rat oral 13-week - p.18
Regulatory source - 346 - - oral chronic - p.12
Regulatory source dermal absorption 0.4 % - dermal - dermal absorption p.55
Regulatory source dermal absorption 0.4 % - oral - dermal absorption p.26
Regulatory source dermal absorption =1.19 mg/kg/d rat oral chronic dermal absorption p.55
Regulatory source dermal absorption 271 mg/kg bw/day rat oral chronic dermal absorption p.55
Regulatory source dermal absorption =271 mg/kg bw/d - oral - dermal absorption p.26
Regulatory source dermal absorption =271 mg/kg bw/d - dermal - dermal absorption p.26
Regulatory source genotoxicity 271 mg/kg bw/day - oral 28 day genotoxicity p.31
Regulatory source irritation 20.2 % rat - - irritation p.23
Regulatory source irritation 93.2 % rat - - irritation p.38
Regulatory source irritation 346 mg/kg bw/day rat - - irritation p.26
Regulatory source repeated dose toxicity 0.8 % - oral 28 day repeated dose toxicity p.12
Regulatory source repeated dose toxicity 12 - rat oral sub-chronic repeated dose toxicity p.40
Regulatory source repeated dose toxicity 13 - rat - sub-chronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity 207 mg/kg bw/day - oral subchronic repeated dose toxicity p.57
Regulatory source repeated dose toxicity =271 mg/kg bw/d human inhalation chronic repeated dose toxicity p.55
Regulatory source repeated dose toxicity 271 mg/kg bw/day - oral 28 day repeated dose toxicity p.12
Regulatory source repeated dose toxicity 271 mg/kg bw/day rat oral 28 day repeated dose toxicity p.12
Regulatory source repeated dose toxicity 271 mg/kg bw/day rat - Chronic repeated dose toxicity p.13
Regulatory source repeated dose toxicity 837 - rat oral sub-chronic repeated dose toxicity p.40
Regulatory source repeated dose toxicity 837 - - oral sub-chronic repeated dose toxicity p.55
Regulatory source repeated dose toxicity 6000 ppm - oral 28 day repeated dose toxicity p.29
Regulatory source reproductive toxicity 0 - - oral - reproductive toxicity p.40
Regulatory source reproductive toxicity =1.24 mg/kg/d human inhalation chronic reproductive toxicity p.55
Regulatory source reproductive toxicity 7 - rat oral - reproductive toxicity p.45
Regulatory source reproductive toxicity 207 mg/kg bw/day rat - chronic reproductive toxicity p.13
Regulatory source reproductive toxicity 15000 ppm rat - - reproductive toxicity p.48
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier XPD6ZY79TB UNII - - - chemical -