Good Cosmetic Ingredient NOAEL Data

Ethyl Menthane Carboxamide

INCI: ETHYL MENTHANE CARBOXAMIDE

CAS Number
39711-79-0
Function
Cooling agent providing menthol-type sensorial effect without menthol odor
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted with no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Ethyl Menthane Carboxamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 300 other oral rat oral REACH
LOAEL 600 other oral dog oral REACH
LOAEL 100 other oral dog oral REACH
NOEL 8 other oral rat oral REACH

Expert Verdict

Patch test recommended for hypersensitive individuals; suitable for all skin types; vegan and halal

โš ๏ธ
Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Ethyl Menthane Carboxamide safe in cosmetics?

Patch test recommended for hypersensitive individuals; suitable for all skin types; vegan and halal The EU classifies Ethyl Menthane Carboxamide as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.

Is Ethyl Menthane Carboxamide allowed in the EU?

Ethyl Menthane Carboxamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Menthane Carboxamide do in cosmetics?

Ethyl Menthane Carboxamide functions as: Cooling agent providing menthol-type sensorial effect without menthol odor. It is classified as a cosmetic ingredient in our database. CAS number: 39711-79-0.

What is the Margin of Safety for Ethyl Menthane Carboxamide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethyl Menthane Carboxamide?

The NOAEL (No Observed Adverse Effect Level) for Ethyl Menthane Carboxamide is 300 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.

๐Ÿ“ฑ

Is Ethyl Menthane Carboxamide in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ethyl Menthane Carboxamide in your formulation.