NOAEL Studies Cosmetic Ingredient

Ethyl Phenylacetate NOAEL Studies

INCI: ETHYL PHENYLACETATE

CAS: 101-97-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_225; row=10893; data_type=In Vivo; mixture=Chemical; chemical_name=Ethyl phenylacetate; preferred_name=Benzeneacetic acid, ethyl ester; dtxsid=DTXSID6044353; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044353; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1842; Record_ID=skin_sensitization_invivo_570; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6044353; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90091-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044353
NTP_ICE_skin_sensitization Induction dose per skin area 5184 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1841; Record_ID=skin_sensitization_invivo_570; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6044353; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90091-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044353
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1844; Record_ID=skin_sensitization_invivo_570; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6044353; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90091-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044353
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =250 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f5b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18837/7/6/2?documentUUID=8cafc838-9346-4b4b-a98e-311c5a719b24; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=body weight and weight gain|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845894_15850149:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e046200540c3afd7e85e10b5cb4ff75
ToxValDB_ECHA_IUCLID LOAEL =800 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18837/7/9/2?documentUUID=8cafc838-9346-4b4b-a98e-311c5a719b24; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856783_15862476:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11c31dcdeea25a44d30b9dbc58126d44
ToxValDB_ECHA_IUCLID NOAEL =60 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f5b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18837/7/6/2?documentUUID=8cafc838-9346-4b4b-a98e-311c5a719b24; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845894_15850149:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_164c26cc1754d03e91ac670416767f9c
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral subchronic (developmental); 48 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f5ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18837/7/6/2?documentUUID=8cafc838-9346-4b4b-a98e-311c5a719b24; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15847870:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f92c06c2e5f48aaf29dbc0ca22c64128
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =4.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632081:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31596c5344a4a8b8003554bbcaecf0c2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier V6CNZ04D8O UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V6CNZ04D8O"}
openFDA substances FDA UNII substance identifier V6CNZ04D8O UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V6CNZ04D8O"}
openFDA substances FDA UNII substance identifier V6CNZ04D8O UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V6CNZ04D8O"}
openFDA substances FDA UNII substance identifier V6CNZ04D8O UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V6CNZ04D8O"}