Is Ethyl Phenylacetate safe in cosmetics?
Ethyl Phenylacetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Ethyl Phenylacetate
Also known as: Benzeneacetic acid, ethyl ester, 4-09-00-01618, BRN 0509140, EINECS 202-993-8, Ethyl phenylethanoate (+5 more)
INCI: ETHYL PHENYLACETATE
Ethyl Phenylacetate (CAS 101-97-3) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming. NOAEL 60 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Fragrance / Perfuming
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
ethyl 2-phenylacetate
InChIKey
DULCUDSUACXJJC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; FEMA GRAS #2452
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Phenylacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Ethyl Phenylacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =60 mg/kg bw/day | oral | Rat | short-term | ECHA |
| NOAEL | =200 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Phenylacetate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
In a human patch pretest the skin irritation potential of the test material was determined. No irritation was found. | Four female albino rabbits were exposed to 0.1 mL of the test article in the left eye. ... Slight signs of irritation were observed on the treated eyes. All effects were fully reversible within 72 hours. Ethyl phenyl acetate shall not be classified as eye irritating.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (4)
JECFA Number
1009
Source: WHO/JECFA
JECFA Evaluation
ETHYL alpha-TOLUATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
JECFA Evaluation
ETHYL PHENYLACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
JECFA Evaluation
ETHYL BENZENEACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Ethyl Phenylacetate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Phenylacetate by CAS number or substance name.
Studies
2
Lowest NOAEL
60 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ECHA
Known Synonyms
Benzeneacetic acid, ethyl ester
4-09-00-01618
BRN 0509140
EINECS 202-993-8
Ethyl phenylethanoate
Ethyl alpha-toluate
FEMA No. 2452
Phenylacetic acid, ethyl ester
alpha-Toluic acid, ethyl ester
UNII-V6CNZ04D8O
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183476
Frequently Asked Questions
Is Ethyl Phenylacetate allowed in the EU?
Ethyl Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Phenylacetate do in cosmetics?
Ethyl Phenylacetate functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 101-97-3.
What is the NOAEL for Ethyl Phenylacetate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Phenylacetate is =60 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Is Ethyl Phenylacetate used outside cosmetics?
Ethyl Phenylacetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Phenylacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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