NOAEL Studies Cosmetic Ingredient

Ethylene Carbonate NOAEL Studies

INCI: ETHYLENE CARBONATE

CAS: 96-49-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11816; row=4203; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Dioxolan-2-one; preferred_name=1,3-Dioxolan-2-one; dtxsid=DTXSID2026600; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026600; source_file=acute_oral.xlsx
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =15 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631958:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a2bc407d7fc3a95682b970fe5bdc7a7
ToxValDB_HPVIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =1500 mg/kg bw/day Rat oral short-term; 9 days reproduction developmental LONG_REF=Margitich, D.J. 1991. Developmental Toxicity Study in Rats, PH 328-TX-001-90, 6398-2220. Pharmakon Research International, Inc., Waverly, PA, pp. 1-46, plus appendices of raw data.; TITLE=Developmental Toxicity Study in Rats, PH 328-TX-001-90, 6398-2220; AUTHOR=Margitich, D.J; QUALITY=1; EXTERNAL_SOURCE_ID=58586; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642504_15642505:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31baf90f0769188ef7c4efbfce97d663
ToxValDB_HPVIS NOAEL =750 mg/kg bw/day Rat oral short-term; 9 days reproduction developmental LONG_REF=Margitich, D.J. 1991. Developmental Toxicity Study in Rats, PH 328-TX-001-90, 6398-2220. Pharmakon Research International, Inc., Waverly, PA, pp. 1-46, plus appendices of raw data.; TITLE=Developmental Toxicity Study in Rats, PH 328-TX-001-90, 6398-2220; AUTHOR=Margitich, D.J; QUALITY=1; EXTERNAL_SOURCE_ID=58587; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642504_15642505:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3447addcb5e1dd721e12f94fb85ade7
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RGJ96TB7R7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RGJ96TB7R7"}
openFDA substances FDA UNII substance identifier RGJ96TB7R7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RGJ96TB7R7"}
openFDA substances FDA UNII substance identifier RGJ96TB7R7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RGJ96TB7R7"}
openFDA substances FDA UNII substance identifier RGJ96TB7R7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RGJ96TB7R7"}