NOAEL Studies
Cosmetic Ingredient
Ethylene Dichloride NOAEL Studies
INCI: ETHYLENE DICHLORIDE
CAS: 107-06-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =58 | mg/kg/day | Rat (F344/N; Sprague-Dawley; Osborne-Mendel; F) | oral | subchronic; 13 weeks | subchronic | ATSDR MRLs; row_hash=24c9abed6063686d; source_hash=ToxValhc_48a8c68b2bd53d7ec352865cce4e734d; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=58; raw_unit=mg/kg/day; method=drinking water; effect=Kidney weight: relative | renal tubular regeneration|Kidney weight: absolute; effect_category=nonneoplastic histopathology|organ weight; file=toxval_ATSDR_MRLs.xlsx; long_ref=NTP. 1991a. Toxicity studies of 1,2-dichloroethane (ethylene dichloride) (CAS No. 107-06-2) in F344/N rats, Sprague Dawley rats, Osborne-Mendel rats and B6C3F1 mice (drinking water and gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institute of Health, National Toxicology Program. NIH Publication No. 91-3123.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bd4 |
COSMOS_DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 149 | mg/kg bw/day | mouse | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 47 | mg/kg bw/day | rat | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 720 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 160 | mg/kg bw/day | rat | oral | 49 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 444.2 | mg/kg bw/day | mouse | oral | 364 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"20, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"20, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"20, Sup 7, 71"} |
INCHEM_WHO_ehc_ehc_ehc176 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =150 | mg/kg bw/day | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=be1043b47e66adf1; raw_unit=mg/kg body weight per day; context=The authors considered the no-observed-effect levels (NOEL) for 1,2-dichloroethane administered to F344/N rats by gavage to be 120 and 150 mg/kg body weight per day in males and females, respectively, based on mortality and chemically related lesions in the forestomach. |
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =780 | mg/kg bw/day | Mouse | oral | - | Toxicology study | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=47e28f4a605dba0a; raw_unit=mg/kg body weight per day; context=The NOEL of B6C3F 1 mice exposed via drinking-water was considered to be 780 mg/kg body weight per day) (2000 ppm) in males, based on kidney lesions, and (2500 mg/kg body weight per day) (4000 ppm) in females, based on mortality. |
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =41.6 | mg/L | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=bdb17a6f537bd11e; raw_unit=mg/litre; context=r reproductive success, the measured lowest-observed-effect level (LOEL) and no-observed-effect level (NOEL) were 20.7 and 10.6 mg/litre, respectively, while the measured LOEL and NOEL for growth were 71.7 and 41.6 mg/litre, respectively. |
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =150 | mg/kg bw/day | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=be1043b47e66adf1; raw_unit=mg/kg body weight per day; context=The authors considered the no-observed-effect levels (NOEL) for 1,2-dichloroethane administered to F344/N rats by gavage to be 120 and 150 mg/kg body weight per day in males and females, respectively, based on mortality and chemically related lesions in the forestomach. |
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =780 | mg/kg bw/day | Mouse | oral | - | Toxicology study | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=47e28f4a605dba0a; raw_unit=mg/kg body weight per day; context=The NOEL of B6C3F 1 mice exposed via drinking-water was considered to be 780 mg/kg body weight per day) (2000 ppm) in males, based on kidney lesions, and (2500 mg/kg body weight per day) (4000 ppm) in females, based on mortality. |
| INCHEM_WHO_ehc_ehc_ehc176 | NOEL | =41.6 | mg/L | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc176; title=Dichloroethane, 1,2- (EHC 176, 1995, 2nd edition); path=mirror/documents/ehc/ehc/ehc176.htm; row_hash=bdb17a6f537bd11e; raw_unit=mg/litre; context=r reproductive success, the measured lowest-observed-effect level (LOEL) and no-observed-effect level (NOEL) were 20.7 and 10.6 mg/litre, respectively, while the measured LOEL and NOEL for growth were 71.7 and 41.6 mg/litre, respectively. |
INCHEM_WHO_ehc_ehc_ehc62 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc62 | NOAEL | =68 | mg/L | - | - | - | Toxicology study | document_id=ehc_ehc_ehc62; title=Dichloroethane, 1,2- (EHC 62, 1987, 1st edition); path=mirror/documents/ehc/ehc/ehc62.htm; row_hash=f69c4a5284954344; raw_unit=mg/litre; context=A no-observed-adverse-effect level below 68 mg/litre was found for Daphnia magna (Le Blanc, 1980). |
| INCHEM_WHO_ehc_ehc_ehc62 | NOAEL | ~400 | mg/m3 | Rat | - | 9 months | Toxicology study | document_id=ehc_ehc_ehc62; title=Dichloroethane, 1,2- (EHC 62, 1987, 1st edition); path=mirror/documents/ehc/ehc/ehc62.htm; row_hash=f075346612bd6820; raw_unit=mg/m 3; context=The no-observed-adverse-effect level for short- term exposures (4 - 9 months) in rats studied in the 3 investigations is about 400 mg/m 3 . |
INCHEM_WHO_hsg_hsg_hsg055 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_hsg_hsg_hsg055 | NOEL | ~400 | mg/m3 | Rat | - | 9 months | Toxicology study | document_id=hsg_hsg_hsg055; title=Dichloroethane 1,2- (HSG 55, 1991); path=mirror/documents/hsg/hsg/hsg055.htm; row_hash=bc7104ad9e64476c; raw_unit=mg/m 3; context=The overall no-observed-effect level in the rat, for exposure periods ranging from 4 to 9 months, was about 400 mg/m 3 . |
| INCHEM_WHO_hsg_hsg_hsg055 | NOEL | ~400 | mg/m3 | Rat | - | 9 months | Toxicology study | document_id=hsg_hsg_hsg055; title=Dichloroethane 1,2- (HSG 55, 1991); path=mirror/documents/hsg/hsg/hsg055.htm; row_hash=bc7104ad9e64476c; raw_unit=mg/m 3; context=The overall no-observed-effect level in the rat, for exposure periods ranging from 4 to 9 months, was about 400 mg/m 3 . |
NTP_ICE_acute_inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 4.0445 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3305; Record_ID=acute_inhalation_2583; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.0445; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_acute_inhalation | LC50 | 7.758 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3306; Record_ID=acute_inhalation_549; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.758; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15430/7/3/3/?documentUUID=71e76ea4-ee79-4a24-9a76-816916bd26a4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_acute_inhalation | LC50 | >8.089 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3307; Record_ID=acute_inhalation_548; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=8.089; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15430/7/3/3/?documentUUID=3adbe8a9-1f0b-4912-bfbd-1de930d49da2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_acute_inhalation | LC50 | 5.1 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3308; Record_ID=acute_inhalation_1585; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.1; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >670 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_983; row=9938; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Dichloroethane; preferred_name=1,2-Dichloroethane; dtxsid=DTXSID6020438; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020438; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <890 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_985; row=9939; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Dichloroethane; preferred_name=1,2-Dichloroethane; dtxsid=DTXSID6020438; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020438; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 115.7 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2315; Record_ID=adme_parameters_1120; Data_Type=Measured; DTXSID=DTXSID6020438; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=115.7; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_adme_parameters | Clint | 21.34 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2318; Record_ID=adme_parameters_1120; Data_Type=Measured; DTXSID=DTXSID6020438; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=21.34; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_adme_parameters | Fu | 0.6167 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2316; Record_ID=adme_parameters_1120; Data_Type=Measured; DTXSID=DTXSID6020438; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.6167; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_adme_parameters | Fu | 0.3475 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2317; Record_ID=adme_parameters_1120; Data_Type=Measured; DTXSID=DTXSID6020438; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.3475; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
NTP_ICE_cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6431; Record_ID=cancer_3290; Data_Type=WOE; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/38; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_cancer | Inhalation risk unit | 0.000026 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=6425; Record_ID=cancer_3293; Data_Type=WOE; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=2.5999999999999998E-5; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0149_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_cancer | Oral slope factor | 0.091 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=6423; Record_ID=cancer_3292; Data_Type=WOE; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=9.0999999999999998E-2; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0149_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_cancer | Top dose | 95 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6415; Record_ID=cancer_3285; Data_Type=In Vivo; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=95; Response_Unit=mg/kg/day; Species=Rat; Strain=Osborne Mendel; Sex=Female; Route=Gavage; Reference=TR-055; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr055/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_cancer | Top dose | 195 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6419; Record_ID=cancer_3288; Data_Type=In Vivo; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=195; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-055; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr055/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
| NTP_ICE_cancer | Top dose | 299 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6420; Record_ID=cancer_3289; Data_Type=In Vivo; Formulation_Name=1,2-Dichloroethane; Mixture=Chemical; DTXSID=DTXSID6020438; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=299; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-055; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr055/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020438; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020438 |
ToxRefDB_ToxRefDB_v3_pod.csv 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =102 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3200; toxval_study_source_id=studyid3200_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|pathology microscopic-kidney-regeneration|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =86 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3200; toxval_study_source_id=studyid3200_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-liver-relative to body weight|in life observation-body weight-body weight|in life observation-water consumption-water consumption|clinical chemistry-urea nitrogen-urea nitrogen|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc); dose_level=2; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =82 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-nos|in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =88 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-nos|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-water consumption-water consumption|in life observation-body weight-body weight|organ weight-kidney-nos; dose_level=2; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =18 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3203; toxval_study_source_id=studyid3203_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-abnormal posture|pathology microscopic-thymus-necrosis|pathology microscopic-brain-necrosis|in life observation-clinical signs-emaciation|in life observation-clinical signs-tremors|in life observation-clinical signs-respiration (dyspnea)|pathology microscopic-stomach-hyperplasia|in life observation-mortality-mortality|in life observation-clinical signs-salivation|in life observation-body weight-body weight; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Gavage)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3203; toxval_study_source_id=studyid3203_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-clinical signs-tremors|in life observation-clinical signs-respiration (dyspnea)|in life observation-mortality-mortality|in life observation-clinical signs-emaciation|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-mineralization|pathology microscopic-brain-necrosis|in life observation-clinical signs-salivation|pathology microscopic-thymus-necrosis|pathology microscopic-stomach-inflammation|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-fur (altered appearance)|in life observation-body weight-body weight; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Gavage)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =244 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=3204; toxval_study_source_id=studyid3204_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|in life observation-body weight-body weight|organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-mortality-mortality; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =249 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=3204; toxval_study_source_id=studyid3204_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|pathology microscopic-kidney-regeneration|organ weight-liver-absolute|pathology microscopic-kidney-karyomegaly|pathology microscopic-kidney-mineralization|pathology microscopic-kidney-casts; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =47 | mg/kg bw/day | rat | oral | 0 week to 110 week | CHR | study_id=3205; toxval_study_source_id=studyid3205_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-intestine large-hemangiosarcoma|pathology microscopic-mammary gland-fibroadenoma|in life observation-clinical signs-hunched posture|in life observation-clinical signs-squinting|pathology microscopic-stomach-squamous cell carcinoma|in life observation-mortality-mortality|in life observation-clinical signs-abdominogenital staining|pathology microscopic-stomach-hyperkeratosis|in life observation-clinical signs-palpable mass|pathology microscopic-spleen-hemangiosarcoma|in life observation-clinical signs-labored respiration|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|pathology microscopic-stomach-acanthosis|pathology microscopic-pancreas-hemangiosarcoma|pathology microscopic-kidney-adenocarcinoma|pathology microscopic-[other]-[other]|pathology microscopic-liver-hemangiosarcoma|pathology microscopic-mammary gland-adenocarcinoma|pathology microscopic-kidney-adenoma; dose_level=1; study_year=1978; study_citation=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Rat_TR-55; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =149 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 91 week | CHR | study_id=3206; toxval_study_source_id=studyid3206_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-alopecia|in life observation-clinical signs-palpable mass|pathology microscopic-uterus-sarcoma|pathology microscopic-uterus-adenocarcinoma|pathology microscopic-lung-adenoma|pathology microscopic-spleen-hemangiosarcoma|pathology microscopic-mammary gland-adenocarcinoma|pathology microscopic-stomach-squamous cell carcinoma|pathology microscopic-uterus-polyp|in life observation-clinical signs-external lesion(s)|in life observation-mortality-mortality|in life observation-body weight-body weight|pathology microscopic-lung-carcinoma; dose_level=1; study_year=1978; study_citation=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =97 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 91 week | CHR | study_id=3206; toxval_study_source_id=studyid3206_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-lung-adenoma|in life observation-clinical signs-alopecia|pathology microscopic-liver-carcinoma|in life observation-clinical signs-palpable mass|in life observation-clinical signs-external lesion(s)|pathology microscopic-stomach-squamous cell carcinoma|pathology microscopic-lymph node-hemangiosarcoma|pathology microscopic-spleen-hemangiosarcoma; dose_level=1; study_year=1978; study_citation=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =213 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-nos|in life observation-body weight-body weight; dose_level=3; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =146 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-nos; dose_level=3; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =299 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 91 week | CHR | study_id=3206; toxval_study_source_id=studyid3206_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1978; study_citation=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; dsstox_substance_id=DTXSID6020438; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =58 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3200; toxval_study_source_id=studyid3200_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|organ weight-liver-relative to body weight|pathology microscopic-kidney-regeneration|in life observation-water consumption-water consumption|organ weight-liver-absolute; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =49 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=3200; toxval_study_source_id=studyid3200_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|organ weight-liver-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-urea nitrogen-urea nitrogen|organ weight-liver-relative to body weight|organ weight-kidney-absolute; dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|organ weight-kidney-nos|in life observation-body weight-body weight; dose_level=0; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =54 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-nos|in life observation-water consumption-water consumption|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-nos|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-body weight-body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc); dose_level=1; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =126 | mg/kg bw/day | rat | oral | 0 week to 13 week | SUB | study_id=3202; toxval_study_source_id=studyid3202_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|organ weight-kidney-nos|in life observation-body weight-body weight; dose_level=2; study_year=1991; study_citation=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; dsstox_substance_id=DTXSID6020438; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ATSDR_MRLs 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | BMCL (10) | =232.382 | mg/m3 | Rat | inhalation | acute; 1 days | acute | LONG_REF=J.A. Hotchkiss, A.K. Andrus, K.A. Johnson, S.M. Krieger, M.R. Woolhiser, J.P. Maurissen, Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats, Food and Chemical Toxicology, Volume 48, Issue 2, 2010, 470-481.; TITLE=Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats; AUTHOR=J.A. Hotchkiss; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bd4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp38.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447505_15447506:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_24adc0667af3b0ccd7e0ddbd72460686 |
| ToxValDB_ATSDR_MRLs | BMCL (HEC) | =37.1924 | mg/m3 | Rat | inhalation | acute; 1 days | acute | LONG_REF=J.A. Hotchkiss, A.K. Andrus, K.A. Johnson, S.M. Krieger, M.R. Woolhiser, J.P. Maurissen, Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats, Food and Chemical Toxicology, Volume 48, Issue 2, 2010, 470-481.; TITLE=Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats; AUTHOR=J.A. Hotchkiss; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bd4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp38.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447505_15447506:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e265bfc6c2176ec418dd5a24fe5ddce0 |
| ToxValDB_ATSDR_MRLs | LOAEL | =58 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP. 1991a. Toxicity studies of 1,2-dichloroethane (ethylene dichloride) (CAS No. 107-06-2) in F344/N rats, Sprague Dawley rats, Osborne-Mendel rats and B6C3F1 mice (drinking water and gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institute of Health, National Toxicology Program. NIH Publication No. 91-3123.; TITLE=Toxicity studies of 1,2-dichloroethane (ethylene dichloride) (CAS No. 107-06-2) in F344/N rats, Sprague Dawley rats, Osborne-Mendel rats and B6C3F1 mice (drinking water and gavage studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bd4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp38.pdf; TOXICOLOGICAL_EFFECT=Kidney weight: relative | renal tubular regeneration|Kidney weight: absolute; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ATSDR MRLs:15447507:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_48a8c68b2bd53d7ec352865cce4e734d |
| ToxValDB_ATSDR_MRLs | MRL | =1.21412 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs:15446995:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc9caff1871528c9f8432640d81b1ee4 |
| ToxValDB_ATSDR_MRLs | MRL | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=renal; STUDY_GROUP=ATSDR MRLs:15446996:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_496d6f1f3fe53438869ed3e1d541e8d5 |
| ToxValDB_ATSDR_MRLs | MRL | =1.21412 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs:15446995:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc9caff1871528c9f8432640d81b1ee4 |
| ToxValDB_ATSDR_MRLs | MRL | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=renal; STUDY_GROUP=ATSDR MRLs:15446996:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_496d6f1f3fe53438869ed3e1d541e8d5 |
ToxValDB_Alaska_DEC 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Alaska_DEC | RfD | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445758:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1cbdaa367d76a8b5a36f4e2d2b348117 |
| ToxValDB_Alaska_DEC | RfD | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445758:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1cbdaa367d76a8b5a36f4e2d2b348117 |
ToxValDB_Cal_OEHHA_REL_derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | NOAEL | =40.4706 | mg/m3 | Rat | inhalation | chronic; 12 months | chronic | LONG_REF=Spreafico F, Zuccato E, Marcucci F, Sironi M, Paglialunga S, Madonna M, and Mussini E. 1980. Pharmacokinetics of ethylene dichloride in rats treated by different routes and its long-term inhalatory toxicity. In: Banbury Report 5. Ethylene Dichloride: A Potential Health Risk? Ames B, Infante P, and Reitz R. (eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory. pp. 107-129.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Significant elevation in liver enzymes; STUDY_GROUP=Cal OEHHA REL derivations:15952058:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a67a79ed0d40ea3a2073c295cc1b77c3 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =250917 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=DOE Protective Action Criteria:15515420:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8bd09b78037e772dd15ce17f2a8d1def |
ToxValDB_DOE_Wildlife_Benchmarks 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Wildlife_Benchmarks | LOAEL | =34.4 | mg/kg bw/day | Chicken | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511603_15511604:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26a546a71512ce67a36b9d6ea7718447 |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =50 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511602:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be959761a06dd6c081259992fbed51bb |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =17.2 | mg/kg bw/day | Chicken | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511603_15511604:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6228c387c13b5c2ddf74e14f806c9812 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =184 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b913c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23876/7/9/2?documentUUID=24013d1f-095b-4a36-921c-b9d4f1862eef; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=F1: developmental neurotoxicity|F1: developmental immunotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15860630:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3bcab7a9c26858aba70f4e8de7b1e8d8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b9144; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23876/7/9/2?documentUUID=24013d1f-095b-4a36-921c-b9d4f1862eef; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=F1: viability|F1: mortality|F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15860858:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4105db7d82a7df41737ce0eb3abc232e |
| ToxValDB_ECHA_IUCLID | NOAEL | =155 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b913c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23876/7/9/2?documentUUID=24013d1f-095b-4a36-921c-b9d4f1862eef; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: water consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: reproductive function (sperm measures)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15861067:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd001a7efc231809f9aaeb46c2d0b1d6 |
| ToxValDB_ECHA_IUCLID | NOAEL | =169 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b913c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23876/7/9/2?documentUUID=24013d1f-095b-4a36-921c-b9d4f1862eef; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=F1: developmental neurotoxicity|F1: developmental immunotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15861414:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_67d0d79e8f90f684339c96867b880691 |
| ToxValDB_ECHA_IUCLID | NOAEL | =182 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b913c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23876/7/9/2?documentUUID=24013d1f-095b-4a36-921c-b9d4f1862eef; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: water consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: reproductive function (oestrous cycle)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15861892:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ad883139a59c6d562f6604c6d3ca54c |
ToxValDB_ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =134 | mg/kg bw/day | Rat | oral | acute; 0.875 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.13(4): 167-184 Kitchin,K.T., J.L. Brown, and A.P. Kulkarni Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters 1993; TITLE=Predicting Rodent Carcinogenicity of Halogenated Hydrocarbons by In Vivo Biochemical Parameters; AUTHOR=Kitchin,K.T., J.L. Brown, and A.P. Kulkarni; DOI=10.1002/tcm.1770130403; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70486; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601846_15601847:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e0bc019493261448e0627985184dff51 |
| ToxValDB_ECOTOX | NOEL | =376 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Mutagenesis14(2): 207-215 Crebelli,R., A. Carere, P. Leopardi, L. Conti, F. Fassio, F. Raiteri, D. Barone, P. Ciliutti, S. Cinelli, and J.A. Veri Evaluation of 10 Aliphatic Halogenated Hydrocarbons in the Mouse Bone Marrow Micronucleus Test 1999; TITLE=Evaluation of 10 Aliphatic Halogenated Hydrocarbons in the Mouse Bone Marrow Micronucleus Test; AUTHOR=Crebelli,R., A. Carere, P. Leopardi, L. Conti, F. Fassio, F. Raiteri, D. Barone, P. Ciliutti, S. Cinelli, and J.A. Veri; DOI=10.1093/mutage/14.2.207; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=93684; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15597876:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=135ad38dd84f1f7ddda3f78a910e9233 |
| ToxValDB_ECOTOX | NOEL | =2 | mmol/kg | Mouse | injection | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.66:33-43 King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems 1979; TITLE=Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems; AUTHOR=King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild; DOI=10.1016/0165-1218(79)90005-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=181059; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15597954:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=68331cc291fcf02a6eb417d14557cfbf |
| ToxValDB_ECOTOX | NOEL | =200 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.77(1): 36-46 Storer,R.D., and R.B. Conolly An Investigation of the Role of Microsomal Oxidative Metabolism in the In Vivo Genotoxicity of 1,2-Dichloroethane 1985; TITLE=An Investigation of the Role of Microsomal Oxidative Metabolism in the In Vivo Genotoxicity of 1,2-Dichloroethane; AUTHOR=Storer,R.D., and R.B. Conolly; DOI=10.1016/0041-008x(85)90265-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74921; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Sorbitol dehydrogenase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECOTOX:15603468:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cd7970e8375efa36d2f5ad767798b5a0 |
ToxValDB_EPA_TSCA_8e 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =10198.6 | mg/m3 | Rat | inhalation | acute; 4 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20809_Combined.pdf; TOXICOLOGICAL_EFFECT=mortality, weight loss, clinical signs of toxicity; STUDY_GROUP=EPA TSCA 8e:15956159:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0219f68bc9abd34df226b5dd43f1d80 |
| ToxValDB_EPA_TSCA_8e | LEL | =8094.11 | mg/m3 | Rat | inhalation | acute; 4 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88050000234_107062_A9C0C63297199043852570ED00591263.PDF; TOXICOLOGICAL_EFFECT=decreased liver weight, liver and kidney histopathologic effects; STUDY_GROUP=EPA TSCA 8e:15956160:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e041ddc37b6602d5f2d7363d99387dc8 |
| ToxValDB_EPA_TSCA_8e | LEL | =809.411 | mg/m3 | Rat | inhalation | acute; 4 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88050000234_107062_A9C0C63297199043852570ED00591263.PDF; TOXICOLOGICAL_EFFECT=nasal histopathological lesions; STUDY_GROUP=EPA TSCA 8e_dup_-_15956162_15956163_15956164:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cb593dab8311237d83eff7806ab7977e |
| ToxValDB_EPA_TSCA_8e | LEL | =40.4706 | mg/m3 | Mouse | inhalation | chronic; 10 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88010000119_106467_97B81793CFD47C77852578D4004B3990.pdf; TOXICOLOGICAL_EFFECT=hemangiosarcoma of liver; STUDY_GROUP=EPA TSCA 8e:15956165:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a006c3f042dbc14f499f42a3bcfff5b2 |
| ToxValDB_EPA_TSCA_8e | NOEL | =2428.23 | mg/m3 | Rat | inhalation | acute; 4 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88050000234_107062_A9C0C63297199043852570ED00591263.PDF; TOXICOLOGICAL_EFFECT=no kidney and liver effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15956162_15956163_15956164:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3f19362283519661ff5362a1e6d0a684 |
ToxValDB_HESS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <76 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e15e4b0a676289df61f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Right kidney: absolute organ weight increase | Right kidney: relative organ weight increase; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HESS:15638130:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ccaad991ce47e7a2950c65ee98cfbfe9 |
| ToxValDB_HESS | NOEL | <30 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e17e4b0a676289df725; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Right kidney: absolute organ weight increase; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HESS:15638801:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f35f7900d52382c191f318c38cc6d4f9 |
| ToxValDB_HESS | NOEL | <18 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e17e4b0a676289df725; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Liver: absolute organ weight increase| Liver: relative organ weight increase; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HESS:15638918:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4baed3a878deab501d4271529c9e4e97 |
ToxValDB_MN_MDH_HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_MN_MDH_HHBW | LOAEL | =58 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=National Toxicology Porgram (NTP). (1991). NTP technical report on the toxicity studies of 1,2Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CAS No. 107-06-2). Toxic Rep Ser, 4, 154; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4e7d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/12dichloroeth.pdf; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Increase kidney weights (supported as adverse by tubular regeneration lesions seen at higher doses in the same study); STUDY_GROUP=MN MDH HHBW:15952794:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0aa368d4b0f2e691c37984bf4bdf8f18 |
ToxValDB_PPRTV_(CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | LOAEL (HEC) | =22 | mg/m3 | Human | inhalation | - | epidemiologic | LONG_REF=Kozik 1957; AUTHOR=Kozik; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aea7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1682; TOXICOLOGICAL_EFFECT=neurobehavioral impairment; STUDY_GROUP=PPRTV (CPHEA):15653236:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6448233cb57c0f1372b5c8509cdf268c |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.07 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Kozik 1957; AUTHOR=Kozik; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aea7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1682; TOXICOLOGICAL_EFFECT=neurobehavioral impairment; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653234_15653235:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a7739002a9fe7f8e1e3eda4f8f8ecb83 |
ToxValDB_Pennsylvania_DEP_ToxValues 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.007 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650022:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa6adfb1cb02bf38bd1f9abd7bb1e238 |
| ToxValDB_Pennsylvania_DEP_ToxValues | RfD | =0.006 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650020:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e38f0e18c84690e3591cc798b4e5b3e |
ToxValDB_ToxRefDB 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =102 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3200; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-regeneration|systemic: organ weight-liver-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699852_15699853_15699854_15699855:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1eb7fbd97e69526c580e810c90b3e86 |
| ToxValDB_ToxRefDB | LEL | =86 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3200; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699856_15699857_15699858_15699859:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf4e8b7c2f07701abb9088bfeb4d1011 |
| ToxValDB_ToxRefDB | LEL | =82 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-nos|systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699860_15699861_15699862:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a2e0d74a3cccdab5552ee6357de2e15 |
| ToxValDB_ToxRefDB | LEL | =88 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-nos|systemic: in life observation-water consumption-water consumption|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: organ weight-kidney-nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699863_15699864_15699865_15699866:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_19e4e2aa0a1a1634888200c5e047263f |
| ToxValDB_ToxRefDB | LEL | =244 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice_TOX-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3204; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699871_15699872:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_194e6c5d16c80a5a6d66309f58e811d9 |
| ToxValDB_ToxRefDB | LEL | =249 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice_TOX-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies)_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3204; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-kidney-regeneration|systemic: organ weight-liver-absolute|systemic: pathology microscopic-kidney-casts|systemic: pathology microscopic-kidney-mineralization|systemic: pathology microscopic-kidney-karyomegaly; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699873_15699874:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c85b8a0a9154a3f003a0c7a7a50b2677 |
| ToxValDB_ToxRefDB | LEL | =47 | mg/kg bw/day | Rat | oral | chronic; 110 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Rat_TR-55; TITLE=Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3205; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hemangiosarcoma|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|systemic: pathology microscopic-intestine large-hemangiosarcoma|systemic: pathology microscopic-mammary gland-fibroadenoma|systemic: in life observation-clinical signs-hunched posture|systemic: in life observation-clinical signs-squinting|systemic: pathology microscopic-stomach-squamous cell carcinoma|systemic: pathology microscopic-stomach-acanthosis|systemic: in life observation-clinical signs-palpable mass|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-abdominogenital staining|systemic: pathology microscopic-mammary gland-adenocarcinoma|systemic: pathology microscopic-pancreas-hemangiosarcoma|systemic: pathology microscopic-[other]-[other]|systemic: pathology microscopic-liver-hemangiosarcoma|systemic: pathology microscopic-kidney-adenocarcinoma|systemic: pathology microscopic-kidney-adenoma; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15699875_15699876:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13f9bbbf614b3e23441a69b36b7e1d20 |
| ToxValDB_ToxRefDB | LEL | =149 | mg/kg bw/day | Mouse | oral | chronic; 91 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; TITLE=Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3206; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-squamous cell carcinoma|systemic: in life observation-clinical signs-alopecia|systemic: pathology microscopic-uterus-sarcoma|systemic: pathology microscopic-uterus-adenocarcinoma|systemic: pathology microscopic-lung-adenoma|systemic: pathology microscopic-spleen-hemangiosarcoma|systemic: pathology microscopic-uterus-polyp|systemic: in life observation-clinical signs-palpable mass|systemic: in life observation-clinical signs-external lesion(s)|systemic: pathology microscopic-mammary gland-adenocarcinoma|systemic: in life observation-body weight-body weight|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-lung-carcinoma; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15699879_15699880_15699881:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d000e4940f19d49866cf3c6c2a645d6d |
| ToxValDB_ToxRefDB | LEL | =97 | mg/kg bw/day | Mouse | oral | chronic; 91 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; TITLE=Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3206; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-alopecia|systemic: pathology microscopic-lung-adenoma|systemic: pathology microscopic-liver-carcinoma|systemic: in life observation-clinical signs-palpable mass|systemic: in life observation-clinical signs-external lesion(s)|systemic: pathology microscopic-stomach-squamous cell carcinoma|systemic: pathology microscopic-lymph node-hemangiosarcoma|systemic: pathology microscopic-spleen-hemangiosarcoma; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical signs|gross pathology; STUDY_GROUP=ToxRefDB:15699882:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3fa04526a91d88d6e0613a88cfc30410 |
| ToxValDB_ToxRefDB | LOAEL | =213 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: organ weight-kidney-nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699860_15699861_15699862:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b0fabb74a0c4477356729db3fdcc6d46 |
| ToxValDB_ToxRefDB | LOAEL | =146 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-nos; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699863_15699864_15699865_15699866:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbec416ccca45298ca5fb5228ea8b91b |
| ToxValDB_ToxRefDB | LOAEL | =299 | mg/kg bw/day | Mouse | oral | chronic; 91 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse_TR-55; TITLE=Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity_Mouse; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3206; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15699879_15699880_15699881:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afe2db06080bf9bd2e6776c7561fe15b |
| ToxValDB_ToxRefDB | NEL | =49 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat_TOX-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (F344/N Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3200; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: in life observation-water consumption-water consumption|systemic: organ weight-liver-absolute|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-urea nitrogen-urea nitrogen; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699856_15699857_15699858_15699859:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2aa57357df79d410c9f6760fcbdf95ac |
| ToxValDB_ToxRefDB | NEL | =54 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-nos|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: organ weight-liver-nos|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-water consumption-water consumption|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699863_15699864_15699865_15699866:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53d1a32837156a8cf760d9f042c6ca6c |
| ToxValDB_ToxRefDB | NOAEL | =126 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1991_Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat_Tox-4; TITLE=Toxicity Studies of 1,2-Dichloroethane(Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-MendelRats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (Osborne-Mendel Drinking Water)_Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=3202; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption|systemic: organ weight-kidney-nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15699860_15699861_15699862:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e570b9d8d2dee7f265d6cf804d4c036 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 55163IJI47 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"55163IJI47"} |
| openFDA substances | FDA UNII substance identifier | 55163IJI47 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"55163IJI47"} |
| openFDA substances | FDA UNII substance identifier | 55163IJI47 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"55163IJI47"} |
| openFDA substances | FDA UNII substance identifier | 55163IJI47 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"55163IJI47"} |