Poor Cosmetic Ingredient NOAEL Data GHS Classified

Ethylene Dichloride

INCI: ETHYLENE DICHLORIDE

CAS Number
107-06-2
Function
Solvent (industrial, not appropriate for cosmetic use)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Not explicitly listed in 21 CFR cosmetic prohibitions, but EPA classifies as Group B2 probable human carcinogen; use would trigger FDA enforcement under adulteration provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Ethylene Dichloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 149 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 47 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 25 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 444.2 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 25 mg/kg bw/day oral rat Reproductive COSMOS_DB
dose_tested 25 mg/kg bw/day oral rat Chronic COSMOS_DB
dose_tested 444.2 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
dose_tested 25 mg/kg bw/day oral rat Reproductive COSMOS_DB
NOAEL 37.5 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; skull;toxic; cancer;health haz
Hazard Statements
Highly flammable liquid and vapour Harmful if swallowed May be harmful in contact with skin Toxic if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to lungs, liver and kidneys May cause drowsiness or dizziness May cause damage to liver and kidneys through prolonged or repeated exposure Harmful to aquatic life
Short-term Exposure Effects
The vapour is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the kidneys and liver. This may result in impaired functions, liver damage and kidney damage. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys, resulting in impaired functions. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Banned in EU cosmetics. Classified as carcinogen (CLP Carc. 1B; IARC 2B; EPA B2) with hepatotoxic, nephrotoxic, and CNS depressant effects; no safe use level in cosmetics; presence even as trace impurity must be documented and minimized.

⚠️
Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics fda_food_additive eu_cosing_listed jecfa_concern

Frequently Asked Questions

Is Ethylene Dichloride safe in cosmetics?

Banned in EU cosmetics. Classified as carcinogen (CLP Carc. 1B; IARC 2B; EPA B2) with hepatotoxic, nephrotoxic, and CNS depressant effects; no safe use level in cosmetics; presence even as trace impurity must be documented and minimized. The EU classifies Ethylene Dichloride as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.

Is Ethylene Dichloride allowed in the EU?

Ethylene Dichloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylene Dichloride do in cosmetics?

Ethylene Dichloride functions as: Solvent (industrial, not appropriate for cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 107-06-2.

What is the Margin of Safety for Ethylene Dichloride?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethylene Dichloride?

The NOAEL (No Observed Adverse Effect Level) for Ethylene Dichloride is 149 mg/kg bw/day based on a Carcinogenicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is Ethylene Dichloride classified as hazardous under GHS?

Ethylene Dichloride carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed May be harmful in contact with skin Toxic if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to lungs, liver and kidneys May cause drowsiness or dizziness May cause damage to liver and kidneys through prolonged or repeated exposure Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Ethylene Dichloride compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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