Is Ethylene Dichloride safe in cosmetics?
Ethylene Dichloride has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 8 toxicological study endpoint(s) are available in our database.
Ethylene Dichloride
Also known as: 1.2-Ethylene dichloride, Ethane, 1,2-dichloro-, Brocide, Dichlor-Mulsion, Glycol dichloride (+15 more)
INCI: ETHYLENE DICHLORIDE
Ethylene Dichloride (CAS 107-06-2) is a cosmetic cosmetic ingredient functioning as Solvent (industrial, not appropriate for cosmetic use). NOAEL 220 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-06-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethylene Dichloride is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H302, H304, H315, H319, H331, H335, H350).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent (industrial, not appropriate for cosmetic use)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,2-dichloroethane
InChIKey
WSLDOOZREJYCGB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not explicitly listed in 21 CFR cosmetic prohibitions, but EPA classifies as Group B2 probable human carcinogen; use would trigger FDA enforcement under adulteration provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylene Dichloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Ethylene Dichloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 47 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 160 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 444.2 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | =155 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =169 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =182 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =184 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameSkullToxicCancerHealth haz
Hazard Statements
Highly flammable liquid and vapour Harmful if swallowed May be harmful in contact with skin Toxic if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to lungs, liver and kidneys May cause drowsiness or dizziness May cause damage to liver and kidneys through prolonged or repeated exposure Harmful to aquatic life
Short-term Exposure Effects
The vapour is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the kidneys and liver. This may result in impaired functions, liver damage and kidney damage. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys, resulting in impaired functions. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethylene Dichloride across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
20, Sup 7, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHealth HazardHarmful / Irritant
Hazard Class and Category
Flam. Liq. 2; Carc. 1B; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
- H350 May cause cancer
- H302 Harmful if swallowed
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 19-Dec-2011)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Carcinogenic (Article 57a)
Substance of Very High Concern (SVHC)
Included: 19-Dec-2011
Carcinogenic (Article 57a)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 125
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 125
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| ASEAN | banned | - | All cosmetic products prohibited |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (6)
Carcinogen Classification
2B, possibly carcinogenic to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
1,2-Dichloroethane | Group 2B: Possibly carcinogenic to humans | Volume 20: (1979) Some Halogenated Hydrocarbons | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
1,2-Dichloroethane | TR-055: Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2) (1978 ) | 03/06/78 | Clear Evidence | Clear Evidence | Clear Evidence | Clear Evidence | Under the conditions of this study, 1,2-dichloroethane was carcinogenic to Osborne-Mendel rats, causing squamous-cell carcinomas of the forestomach, hemangiosarcomas, and subcutaneous fibromas in
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 1,2-dichloroethane. There is sufficient evidence in experimental animals for the carcinogenicity of 1,2-dichloroethane. Overall evaluation: 1,2-Dichloroethane is possibly carcinogenic to humans (Group 2B). | CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Based on the induction of several tumor t
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0250
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (1)
JECFA Evaluation
1,2-DICHLOROETHANE | 1992 | NO ADI ALLOCATED | Evidence of genotoxicity and carcinogenicity; should not be used in food | TRS 828-JECFA 39/16 | FAS 30-JECFA 39/89
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
No specific technical function
Solvent
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Ethylene Dichloride.
Regulatory Flags
prop65
eu_banned_cosmetics
fda_food_additive
eu_cosing_listed
jecfa_concern
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethylene Dichloride by CAS number or substance name.
Studies
8
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
444.2 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
1.2-Ethylene dichloride
Ethane, 1,2-dichloro-
Brocide
Dichlor-Mulsion
Glycol dichloride
Ethylene chloride
Borer sol
Caswell No. 440
Destruxol borer-sol
Dichloremulsion
Di-chlor-mulsion
Dutch oil
EINECS 203-458-1
EPA Pesticide Chemical Code 042003
NCI-C00511
RCRA waste number U077
RY Dichloro-1,2-ethane
1,2-Dichloorethaan
1,2-Dichlor-aethan
Bichlorure d'ethylene
Chemical Function
Solvent
Biocide
No specific technical function
Regulatory Lists
detected; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
banned; Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Pesticides
active_ingredient; Europe; Pesticides
Cons electronics mech appliances and machinery; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
1,2-DICHLOROETHANE
ChEMBL ID
CHEMBL16370
Frequently Asked Questions
Is Ethylene Dichloride allowed in the EU?
Ethylene Dichloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Dichloride do in cosmetics?
Ethylene Dichloride functions as: Solvent (industrial, not appropriate for cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 107-06-2.
What is the NOAEL for Ethylene Dichloride?
The NOAEL (No Observed Adverse Effect Level) for Ethylene Dichloride is 25 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Is Ethylene Dichloride classified as hazardous under GHS?
Ethylene Dichloride carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed May be harmful in contact with skin Toxic if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to lungs, liver and kidneys May cause drowsiness or dizziness May cause damage to liver and kidneys through prolonged or repeated exposure Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Ethylene Dichloride used outside cosmetics?
Ethylene Dichloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethylene Dichloride have different safety status in cosmetics vs industrial chemicals?
Ethylene Dichloride is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H302, H304, H315, H319, H331, H335, H350).
Compliance Tools
Check Ethylene Dichloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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