NOAEL Studies Cosmetic Ingredient

Ethylenediamine ⚠️ NOAEL Studies

INCI: ETHYLENEDIAMINE

CAS: 107-15-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS_DB	NOAEL	150	mg/kg bw/day	rat	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB	NOAEL	80	mg/kg bw/day	rabbit	oral	14 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB	NOAEL	200	mg/kg bw/day	rat	oral	91 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study

EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx	NOAEL	=15	mg/kg bw/day	Rat	-	-	other	EFSA - 2019 - OutputID 3605 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx	NOAEL	=2.3	mg/kg bw/day	Dog	oral: unspecified	365 days	short-term toxicity	EFSA - 2019 - OutputID 3605 - clinical chemistry - endocrine - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755

EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx	ADI	=0.023	mg/kg bw/day	Consumers	-	-	ADI	EFSA - 2019 - OutputID 3605 - Consumers - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx	ADI	=0.023	mg/kg bw/day	Consumers	-	-	ADI	EFSA - 2019 - OutputID 3605 - Consumers - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx	ARfD	=0.15	mg/kg bw/day	Consumers	-	-	ARfD	EFSA - 2019 - OutputID 3605 - Consumers - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx	ARfD	=0.15	mg/kg bw/day	Consumers	-	-	ARfD	EFSA - 2019 - OutputID 3605 - Consumers - Peer review of the pesticide risk assessment of the active substance mancozeb - doi:10.2903/j.efsa.2020.5755

INCHEM_WHO_cicads_cicads_cicad15 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
INCHEM_WHO_cicads_cicads_cicad15	NOAEL	=9	mg/kg bw/day	-	-	-	Toxicology study	document_id=cicads_cicads_cicad15; title=Ethylenediamine (CICADS); path=mirror/documents/cicads/cicads/cicad15.htm; row_hash=6e195c161642a4cb; raw_unit=mg/kg body weight per day; context=NOAEL, 9 mg/kg body weight per day).

NTP_ICE_acute_inhalation 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_inhalation	LC50	14.7	mg/L	-	Inhalation	Duration=4 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=2827; Record_ID=acute_inhalation_541; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15765/7/3/3/?documentUUID=d35a20f5-b7b8-4c4e-af7c-413cc3738a03; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_acute_inhalation	LC50	7.35	mg/L	-	Inhalation	Duration=8 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=2828; Record_ID=acute_inhalation_540; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.35; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15765/7/3/3/?documentUUID=d35a20f5-b7b8-4c4e-af7c-413cc3738a03; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881

NTP_ICE_skin_irritation 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_skin_irritation	Breakthrough Time	13	min	-	Dermal	-	In Vitro; Corrositex	sheet=Data_invitro; excel_row=3563; Record_ID=skin_irritation_invitro_86; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=Corrositex; Endpoint=Breakthrough Time; Response=13; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881

NTP_ICE_skin_sensitization 36 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_skin_sensitization	CD54, EC200	208.3	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2574; Record_ID=skin_sensitization_invitro_615; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=208.3; Reported_Response_Unit=ug/mL; Response=208.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC120	24.749	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; mMUSST	sheet=Data_invitro; excel_row=7789; Record_ID=skin_sensitization_invitro_1887; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=411.8; Reported_Response_Unit=uM; Conversion_Factor_Value=60.1; Conversion_Factor_Source=EPA Dashboard; Converted_Response=24.749; Converted_Response_Unit=ug/mL; Response=24.749; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	265.7	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2064; Record_ID=skin_sensitization_invitro_514; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=265.7; Reported_Response_Unit=ug/mL; Response=265.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	109	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2553; Record_ID=skin_sensitization_invitro_611; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=109; Reported_Response_Unit=ug/mL; Response=109; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	173.6	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2573; Record_ID=skin_sensitization_invitro_615; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=173.6; Reported_Response_Unit=ug/mL; Response=173.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	91.2	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2583; Record_ID=skin_sensitization_invitro_617; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=91.2; Reported_Response_Unit=ug/mL; Response=91.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	78.3	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2588; Record_ID=skin_sensitization_invitro_618; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=78.3; Reported_Response_Unit=ug/mL; Response=78.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	81.1	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2593; Record_ID=skin_sensitization_invitro_619; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=81.099999999999895; Reported_Response_Unit=ug/mL; Response=81.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	109.2	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2598; Record_ID=skin_sensitization_invitro_620; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=109.2; Reported_Response_Unit=ug/mL; Response=109.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	47	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; U-SENS	sheet=Data_invitro; excel_row=8261; Record_ID=skin_sensitization_invitro_2284; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=782.0299501; Reported_Response_Unit=uM; Conversion_Factor_Value=60.1; Conversion_Factor_Source=EPA Dashboard; Converted_Response=47; Converted_Response_Unit=ug/mL; Response=47; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CD86, EC150	16.11	ug/mL	-	Dermal	-	In Vitro; CE_USENSE2018; U-SENS	sheet=Data_invitro; excel_row=8546; Record_ID=skin_sensitization_invitro_2358; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=16.11; Reported_Response_Unit=ug/mL; Response=16.11; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CV70	58.44	ug/mL	-	Dermal	-	In Vitro; CE_USENSE2018; U-SENS	sheet=Data_invitro; excel_row=8548; Record_ID=skin_sensitization_invitro_2358; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=U-SENS; Endpoint=CV70; Reported_Response=58.44; Reported_Response_Unit=ug/mL; Response=58.44; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CV75	271.7	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2065; Record_ID=skin_sensitization_invitro_514; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CV75; Reported_Response=271.7; Reported_Response_Unit=ug/mL; Response=271.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CV75	200	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2555; Record_ID=skin_sensitization_invitro_611; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CV75; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	CV75	300	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=2575; Record_ID=skin_sensitization_invitro_615; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=h-CLAT; Endpoint=CV75; Reported_Response=300; Reported_Response_Unit=ug/mL; Response=300; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Cys	18.6	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=468; Record_ID=skin_sensitization_invitro_141; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=18.600000000000001; Reported_Response_Unit=%; Response=18.6; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Cys	3.4	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=472; Record_ID=skin_sensitization_invitro_142; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.4; Reported_Response_Unit=%; Response=3.4; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys	0.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=467; Record_ID=skin_sensitization_invitro_141; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys	0	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=471; Record_ID=skin_sensitization_invitro_142; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys	-0.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=475; Record_ID=skin_sensitization_invitro_143; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.3; Reported_Response_Unit=%; Response=-0.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006\|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys + Cys	9.65	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=469; Record_ID=skin_sensitization_invitro_141; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=9.65; Reported_Response_Unit=%; Response=9.65; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys + Cys	1.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=473; Record_ID=skin_sensitization_invitro_142; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.7; Reported_Response_Unit=%; Response=1.7; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Depletion Lys + Cys	0.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=478; Record_ID=skin_sensitization_invitro_143; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006\|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC1.5	549	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4442; Record_ID=skin_sensitization_invitro_1024; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=549; Reported_Response_Unit=uM; Response=549; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC1.5	99.88	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4443; Record_ID=skin_sensitization_invitro_1023; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=99.885000000000005; Reported_Response_Unit=uM; Response=99.88; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC1.5	>750	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7601; Record_ID=skin_sensitization_invitro_1840; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=750; Reported_Response_Unit=uM; Response=750; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC3	453.4	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4444; Record_ID=skin_sensitization_invitro_1023; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=453.35500000000002; Reported_Response_Unit=uM; Response=453.4; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC3	2.2	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13214; Record_ID=skin_sensitization_invivo_3279; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC3	2.2	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13214; Record_ID=skin_sensitization_invivo_3279; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC3	2.2	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13214; Record_ID=skin_sensitization_invivo_3279; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	EC3	2.2	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13214; Record_ID=skin_sensitization_invivo_3279; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	IC50	1793	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4445; Record_ID=skin_sensitization_invitro_1024; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1793; Reported_Response_Unit=uM; Response=1793; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	IC50	>2000	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4446; Record_ID=skin_sensitization_invitro_1023; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Imax	13.19	ratio	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=4447; Record_ID=skin_sensitization_invitro_1023; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.19; Reported_Response_Unit=Unitless; Response=13.19; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868\|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Imax	7.64	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=4448; Record_ID=skin_sensitization_invitro_1024; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.64; Reported_Response_Unit=Unitless; Response=7.64; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881
NTP_ICE_skin_sensitization	Imax	1.116	ratio	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7574; Record_ID=skin_sensitization_invitro_1840; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021881; Assay=LuSens; Endpoint=Imax; Reported_Response=1.115938591; Reported_Response_Unit=Unitless; Response=1.116; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021881; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021881

ToxValDB_DOE_Protective_Action_Criteria 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_DOE_Protective_Action_Criteria	LEL	=61452.2	mg/m3	Human	inhalation	-	acute	LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15515465:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64682dcd7d9391d52c2b9ab395c60689

ToxValDB_ECHA_IUCLID 9 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECHA_IUCLID	LOAEL	=100	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0d9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/6/2?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15836489:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c3e91949a981da2911af829343e5400
ToxValDB_ECHA_IUCLID	LOAEL	=114	mg/kg bw/day	Rat	oral	subchronic; 3 months	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0d9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/6/2?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838952_15838953:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa6da2ce25fdf999870d0accc0823a11
ToxValDB_ECHA_IUCLID	NOAEC	=324.468	mg/m3	Rat	inhalation	subchronic; 6 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/6/3?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15828285:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54f3a35936ba8d0cc5438fc7cb978483
ToxValDB_ECHA_IUCLID	NOAEL	>=8.3	mg/kg bw/day	Mouse	dermal	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215ec5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/8?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15819360:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fa8f18ea2e043f4a8aa6355d7484e4e
ToxValDB_ECHA_IUCLID	NOAEL	>=80	mg/kg bw/day	Rabbit	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/9/3?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821485:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_049f1d2c82a7ffce99eee308af0c955c
ToxValDB_ECHA_IUCLID	NOAEL	=114	mg/kg bw/day	Rat	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3eb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/9/3?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821572:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_795fa24f413f5e3f5f3509008944ece8
ToxValDB_ECHA_IUCLID	NOAEL	=22	mg/kg bw/day	Rat	oral	subchronic; 3 months	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0d9f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/6/2?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838952_15838953:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c46b7c5256127292b0147b395975419f
ToxValDB_ECHA_IUCLID	NOAEL	=23	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/9/2?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855799_15856554:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71bdfd437e0294139b58c85e509607f2
ToxValDB_ECHA_IUCLID	NOAEL	>=227	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55c9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12254/7/9/2?documentUUID=b99ed3e9-1842-4f3c-8260-cbb3d56e45f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855799_15856554:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a6c74c0386f2843fdf330343b9a61f0

ToxValDB_ECOTOX 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECOTOX	LOEL	=400	mg/kg bw/day	Mouse	oral	short-term (developmental); 8 days	reproduction developmental	LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15611719:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=f581b241dad51ce1e4f9ba1780a82878

ToxValDB_EFSA 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_EFSA	NOAEL	=2.3	mg/kg bw/day	Dog	oral	chronic; 1 years	chronic	LONG_REF=EFSA (2019). Peer review of the pesticide risk assessment of the active substance mancozeb. doi:10.2903/j.efsa.2020.5755.; TITLE=Peer review of the pesticide risk assessment of the active substance mancozeb; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2020.5755; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15625540:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c9a50fa8b3c04d46dcd0f1cbfddea821
ToxValDB_EFSA	NOAEL	=15	mg/kg bw/day	Rat	oral	-	repeat dose other	LONG_REF=EFSA (2019). Peer review of the pesticide risk assessment of the active substance mancozeb. doi:10.2903/j.efsa.2020.5755.; TITLE=Peer review of the pesticide risk assessment of the active substance mancozeb; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2020.5755; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15625541:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13f10d34f25d8c542a7bec06c164b285

ToxValDB_GESTIS_DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_GESTIS_DNEL	DNEL systemic	=25	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631967:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d482944108ef50f741d084434c25f9d

ToxValDB_PPRTV_(CPHEA) 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_PPRTV_(CPHEA)	NOAEL	=9	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Hermansky et al. 1999; AUTHOR=Hermansky et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1748; TOXICOLOGICAL_EFFECT=Urinary, Hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15653879:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ecd10e9823d8058830cd87488859b4d2
ToxValDB_PPRTV_(CPHEA)	NOAEL	=23	mg/kg bw/day	Rat	oral	chronic; 22 weeks	chronic	LONG_REF=Yang et al. 1983 and 1984; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1748; TOXICOLOGICAL_EFFECT=Decreased weight gain\|Elevated serum alanine aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|clinical chemistry; STUDY_GROUP=PPRTV (CPHEA):15653910:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49493fc9b1807598a72fa38bf0b30ea0
ToxValDB_PPRTV_(CPHEA)	RfD (provisional)	=0.09	mg/kg bw/day	Human	oral	-	Toxicity Value	LONG_REF=Hermansky et al. 1999; AUTHOR=Hermansky et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1748; TOXICOLOGICAL_EFFECT=Urinary, Hepatic in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653612:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_76d02ef3bf53eac1c003efcc28191102
ToxValDB_PPRTV_(CPHEA)	RfD (provisional)	=0.2	mg/kg bw/day	Human	oral	-	Toxicity Value	LONG_REF=Yang et al. 1983 and 1984; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1748; TOXICOLOGICAL_EFFECT=Decreased weight gain in male/female rats\|Elevated serum alanine aminotransferase in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653663:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bdcd70e078197bdd132bed1dd31ea59e

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	60V9STC53F	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C2H8N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60V9STC53F"}
openFDA substances	FDA UNII substance identifier	60V9STC53F	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C2H8N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60V9STC53F"}
openFDA substances	FDA UNII substance identifier	60V9STC53F	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C2H8N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60V9STC53F"}
openFDA substances	FDA UNII substance identifier	60V9STC53F	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C2H8N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60V9STC53F"}