Is Ethylenediamine ⚠️ safe in cosmetics?
Ethylenediamine ⚠️ has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Ethylenediamine ⚠️
Also known as: 1,2-Ethanediamine, 4-04-00-01166, Algicode 106L, Amerstat 274, beta-Aminoethylamine (+15 more)
INCI: ETHYLENEDIAMINE
Ethylenediamine ⚠️ (CAS 107-15-3) is a cosmetic cosmetic ingredient functioning as Chelating agent, pH adjuster, intermediate (rarely used standalone in finished. Reported NOAEL =22 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 107-15-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethylenediamine ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H311, H312, H314, H317, H318).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating agent, pH adjuster, intermediate (rarely used standalone in finished cosmetics)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
ethane-1,2-diamine
InChIKey
PIICEJLVQHRZGT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — not prohibited under 21 CFR; however, FDA expects safety substantiation for sensitizers
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylenediamine ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Ethylenediamine ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =22 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =114 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarnCorrCancerHealth haz
Hazard Statements
Flammable liquid and vapour Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosiveHealth Hazard
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1
Hazard Statements
- H226 Flammable liquid and vapour
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
3.4%
DPRA Lys %
0%
KeratinoSens IC50
1896.5 µM
hCLAT CV75
300 µg/mL
LLNA EC3
2.5%
NESIL
625 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Source: LLNA: Gerberick et al. (1992) | Kimber et al. (1998); DPRA: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Jaworska 2011 [DOI:10.1002/jat.2869]; KS: Emter et al. 2010 [DOI:10.1016/j.taap.2010.03.009] | Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013]; hCLAT: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
Yes (since 27-Jun-2018)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Respiratory sensitising properties (Article 57(f) - human health)
Substance of Very High Concern (SVHC)
Included: 27-Jun-2018
Respiratory sensitising properties (Article 57(f) - human health)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Evidence for Carcinogenicity
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity | CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human data and inadequate animal data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA:Inadequate. | A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0269
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to skin, eyes, and respiratory system.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Chemical reaction regulator
Corrosion inhibitor
Lubricating agent
No specific technical function
Tracer
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ethylenediamine ⚠️.
Regulatory Flags
potential-allergen
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethylenediamine ⚠️ by CAS number or substance name.
Studies
2
Lowest NOAEL
22 mg/kg bw/day
Highest NOAEL
114 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1,2-Ethanediamine
4-04-00-01166
Algicode 106L
Amerstat 274
beta-Aminoethylamine
BRN 0605263
Caswell No. 437
EINECS 203-468-6
EPA Pesticide Chemical Code 004205
Ethylendiamine
NCI-C60402
1,2-Diaminoaethan
1,2-Diamino-ethaan
1,2-Diamino-ethano
Aethaldiamin
Aethylenediamin
Ethyleendiamine
Ethylene-diamine
UNII-60V9STC53F
en
Chemical Function
Chemical reaction regulator
Chelating agent
Corrosion inhibitor
Lubricating agent
Tracer
No specific technical function
Regulatory Lists
pharmaceutical
active_ingredient; Europe; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHYLENEDIAMINE
ChEMBL ID
CHEMBL816
Max Phase
3
Adverse Event Associations
705
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ETHYLENEDIAMINE
Food Category
food_additive
Frequently Asked Questions
Is Ethylenediamine ⚠️ allowed in the EU?
Ethylenediamine ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylenediamine ⚠️ do in cosmetics?
Ethylenediamine ⚠️ functions as: Chelating agent, pH adjuster, intermediate (rarely used standalone in finished cosmetics). It is classified as a cosmetic ingredient in our database. CAS number: 107-15-3.
What is the NOAEL for Ethylenediamine ⚠️?
The NOAEL (No Observed Adverse Effect Level) for Ethylenediamine ⚠️ is =22 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Ethylenediamine ⚠️ classified as hazardous under GHS?
Ethylenediamine ⚠️ carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Ethylenediamine ⚠️ used outside cosmetics?
Ethylenediamine ⚠️ also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethylenediamine ⚠️ have different safety status in cosmetics vs industrial chemicals?
Ethylenediamine ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H311, H312, H314, H317, H318).
Compliance Tools
Check Ethylenediamine ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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